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Database: UniProt
Entry: W3RKA3_9BRAD
LinkDB: W3RKA3_9BRAD
Original site: W3RKA3_9BRAD 
ID   W3RKA3_9BRAD            Unreviewed;       477 AA.
AC   W3RKA3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   05-JUL-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=X566_07925 {ECO:0000313|EMBL:ETR77571.1};
OS   Afipia sp. P52-10.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Afipia.
OX   NCBI_TaxID=1429916 {ECO:0000313|EMBL:ETR77571.1, ECO:0000313|Proteomes:UP000018975};
RN   [1] {ECO:0000313|Proteomes:UP000018975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P52-10 {ECO:0000313|Proteomes:UP000018975};
RX   PubMed=25874801;
RA   Pickering B.S., Tyler S., Smith G., Burton L., Li M., Dallaire A.,
RA   Weingartl H.;
RT   "Identification of a novel afipia species isolated from an Indian
RT   flying fox.";
RL   PLoS ONE 10:E0121274-E0121274(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETR77571.1}.
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DR   EMBL; AZSJ01000003; ETR77571.1; -; Genomic_DNA.
DR   RefSeq; WP_034464924.1; NZ_AZSJ01000003.1.
DR   EnsemblBacteria; ETR77571; ETR77571; X566_07925.
DR   PATRIC; fig|1429916.3.peg.1603; -.
DR   Proteomes; UP000018975; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018975};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018975}.
FT   DOMAIN      170    296       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      385    454       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     178    185       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   477 AA;  52931 MW;  52AEC207CD33EACF CRC64;
     MANEENDCWS RVKGRLRSTV GEDVFSSWFA RMDLESISDD AAHMSVPTRF LKSWIQAHYA
     DRVLSCWQAE RPTLQRIDLT VRTPMRPAAA VNKDAKTADD LRSDRNVGKA INGLRINGTA
     TPAADSSDAL GSSPLDPRLT FDTFVVGRSN TLAHAAAKQV AEGRRGEPVM FNPLYVHAGV
     GLGKTHLLQA VTFAGNAGGQ RKVLYLTAEK FMYGFVQALK NQTALAFKET LRGIDVLVID
     DLQFLQGKST QAEFCHTLNA LIDSGRQVVI AADRPPSDLE SLDDRVRSRL AGGLVVEMGS
     LGEELRLEIL KSRVATVRTH HAGFDVPLPV LEYLARSITH NGRDLEGAIN RLLAHNTLSG
     HAVTLEMAER EVRDLIRPQE PKRVKIEDIQ RVVARQYNVS RSDLLSSRRT ANVVRPRQVA
     MYLSKTLTLR SLPEIGRRFG GRDHTTVLHA VRKIEALVNK DTTLAEEVEL LKRLLQD
//
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