ID W3Y5A3_9FIRM Unreviewed; 873 AA.
AC W3Y5A3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:ETS93345.1};
GN ORFNames=HMPREF1521_0254 {ECO:0000313|EMBL:ETS93345.1};
OS Veillonella sp. AS16.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Veillonella.
OX NCBI_TaxID=936589 {ECO:0000313|EMBL:ETS93345.1, ECO:0000313|Proteomes:UP000019042};
RN [1] {ECO:0000313|EMBL:ETS93345.1, ECO:0000313|Proteomes:UP000019042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS16 {ECO:0000313|EMBL:ETS93345.1,
RC ECO:0000313|Proteomes:UP000019042};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Haft D.H., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETS93345.1}.
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DR EMBL; AZYX01000007; ETS93345.1; -; Genomic_DNA.
DR RefSeq; WP_038114932.1; NZ_AZYX01000007.1.
DR AlphaFoldDB; W3Y5A3; -.
DR PATRIC; fig|936589.3.peg.270; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000019042; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 508..550
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 873 AA; 98705 MW; 4421E7B03975AFC6 CRC64;
MSKKQTPMME QYLDIKSRYK EELLFFRLGD FYELFNDDAL LASRELNITL TGRPTGDEER
TPMCGVPFHA AESYIETLVK KGYKVAICEQ LEDPKAVKGI VKRDVIKVMT PGTVMTENAN
DARANNFLAL FYMVKDSWVL VFSDVSTGEV IWHRITESDK KSDMYDALSM YRPTEIILPE
GSELPREIRD FIGNQFSNVV FSPFSTYHTQ REVAEQAVAH FGDLGLMEED VWEALGFMLL
YLQDVIKSPI SHINYVHQLS VGNRLILDTS SLHHLEITHN LRDGGQKGTL LDVLDRTLTP
MGARLLKQWL ESPLTDINQI QRRQSAISEL ITRGAERTDL RNKLDCIYDF ERIVGRVETG
SVSPRDLTAL RESLAVLPEL KNTLNICTSL ALTSINERIQ NHRELYDLLY NAIAEQPALT
LKEGRVIKDG YNEELDELRS LTTDSQKWLS KMEEDIKAAT GLSKIKTGYN KVFGYYFEVS
HNKSEQVPDY FIRKQTLSNA ERYITPELKE FEIKILSAKE KMIALEHRLY QDLREQIKAV
IKDIQQTARA LADLDVLCSL ALVGYEENYI CPTLAMNGQI NIRDGRHPVI EKFLKREVFV
PNDVVLNHDD EEFLLITGPN MAGKSTYMRQ VAILMIMAQI GSFIPAREAA ISPVDRIFTR
VGASDDISTG QSTFMVEMKE VAYILENATS NSLIILDEIG RGTSTFDGLS IAQAVVEHIC
KHIHGKTLFA THYHELITLE ETYSKLKNYT VAVKEKGKDV AFLRRIIRGG ADRSYGIHVA
RLAGLPNSVL KRAEVILASL EDQSNDADDL NQRVIIPQAS NVVKQVSEPA TGNLFTHSVV
DSLLDLDVMS MTPIEALNIL YQLQEEARKG GGK
//
