ID W4C5S2_9BACL Unreviewed; 621 AA.
AC W4C5S2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=C162_11531 {ECO:0000313|EMBL:ETT50887.1};
OS Paenibacillus sp. FSL R7-269.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1226755 {ECO:0000313|EMBL:ETT50887.1, ECO:0000313|Proteomes:UP000019056};
RN [1] {ECO:0000313|EMBL:ETT50887.1, ECO:0000313|Proteomes:UP000019056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL R7-269 {ECO:0000313|EMBL:ETT50887.1,
RC ECO:0000313|Proteomes:UP000019056};
RX PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT "Genomic comparison of sporeforming bacilli isolated from milk.";
RL BMC Genomics 15:26-26(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETT50887.1}.
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DR EMBL; ASPS01000021; ETT50887.1; -; Genomic_DNA.
DR RefSeq; WP_036694466.1; NZ_ASPS01000021.1.
DR AlphaFoldDB; W4C5S2; -.
DR PATRIC; fig|1226755.4.peg.2308; -.
DR OrthoDB; 9776552at2; -.
DR Proteomes; UP000019056; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ETT50887.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..384
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 426..614
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 621 AA; 69481 MW; 26226523A261B106 CRC64;
MRKTGVTMEK LKLNNMPIRY KLIIHFLLIS ILPSIGLGLL IGWTVDRIVE EQSTENTMQL
IRKVNTAIES DVENLQKITY LISFDPGVQK FLKGEPPVPA QPDPAAGNGE SAEYNIRKFL
QGFTTLSSEI AGIMLVNREG GFISNEMYTR SGTRLTEESW YKQAVENKGI FLIVGHPYGR
AVRSHVDYKE SEVVSAVRAI VNPETQVVQG VVLVDLKLRV IAETARDVTL GKTGYLTVVD
NRGEMIYAPQ HPLMRTIPAG LFTESSGITS ETVDGRKLQL IYRTSPFTGW TTMGVFPMDE
SAYGIREITF NVVTFVFVVC MLGMTASFYL AYSISRPIGQ LASFMSKAQS GDLTIRYWGS
RSDEIGLLGR SFNTMLAQIG RLLSLTELQA RQKREAELRS LQAHIKPHFL YNTLDTIHWM
ARSKGAEDIA EVVQSLSRLF RLGLSKGSDI IPLSDELEHI VSYLKIQHVR YSTKLTYSIE
VEPHLQELYV LKLLLQPMVE NAIYHGIKER RGPGLLSIAV VERDNDLYLT VRDDGAGMSA
DKLRELRRRL EAVGTEELER TETDMAGTGS AGSGYGILNV QARIRLTYGE PYGIQIESGP
GQGTLVTVRH PVVRESYPEK Y
//
