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Database: UniProt
Entry: W4HIG1_9RHOB
LinkDB: W4HIG1_9RHOB
Original site: W4HIG1_9RHOB 
ID   W4HIG1_9RHOB            Unreviewed;       396 AA.
AC   W4HIG1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=3-deoxy-D-manno-octulosonic acid transferase {ECO:0000256|ARBA:ARBA00019077, ECO:0000256|RuleBase:RU365103};
DE            Short=Kdo transferase {ECO:0000256|RuleBase:RU365103};
DE            EC=2.4.99.12 {ECO:0000256|ARBA:ARBA00012621, ECO:0000256|RuleBase:RU365103};
DE   AltName: Full=Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase {ECO:0000256|ARBA:ARBA00031445, ECO:0000256|RuleBase:RU365103};
GN   ORFNames=ATO8_13041 {ECO:0000313|EMBL:ETW12479.1};
OS   Roseivivax marinus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseivivax.
OX   NCBI_TaxID=1379903 {ECO:0000313|EMBL:ETW12479.1, ECO:0000313|Proteomes:UP000019063};
RN   [1] {ECO:0000313|EMBL:ETW12479.1, ECO:0000313|Proteomes:UP000019063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=22II-s10s {ECO:0000313|EMBL:ETW12479.1,
RC   ECO:0000313|Proteomes:UP000019063};
RX   PubMed=24567080; DOI=10.1007/s10482-014-0140-5;
RA   Li G., Lai Q., Liu X., Sun F., Shao Z.;
RT   "Roseivivax atlanticus sp. nov., isolated from surface seawater of the
RT   Atlantic Ocean.";
RL   Antonie Van Leeuwenhoek 105:863-869(2014).
CC   -!- FUNCTION: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes
CC       the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-
CC       Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate
CC       precursor of lipid A. {ECO:0000256|ARBA:ARBA00003394,
CC       ECO:0000256|RuleBase:RU365103}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) =
CC         alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+);
CC         Xref=Rhea:RHEA:28066, ChEBI:CHEBI:15378, ChEBI:CHEBI:58603,
CC         ChEBI:CHEBI:60364, ChEBI:CHEBI:60377, ChEBI:CHEBI:85987;
CC         EC=2.4.99.12; Evidence={ECO:0000256|ARBA:ARBA00034406,
CC         ECO:0000256|RuleBase:RU365103};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004713, ECO:0000256|RuleBase:RU365103}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365103}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       {ECO:0000256|RuleBase:RU365103}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETW12479.1}.
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DR   EMBL; AQQW01000007; ETW12479.1; -; Genomic_DNA.
DR   RefSeq; WP_043844958.1; NZ_AQQW01000007.1.
DR   AlphaFoldDB; W4HIG1; -.
DR   STRING; 1379903.ATO8_13041; -.
DR   PATRIC; fig|1317118.6.peg.2685; -.
DR   eggNOG; COG1519; Bacteria.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000019063; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043842; F:Kdo transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.11720; 3-Deoxy-D-manno-octulosonic-acid transferase, N-terminal domain; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   InterPro; IPR007507; Glycos_transf_N.
DR   InterPro; IPR038107; Glycos_transf_N_sf.
DR   InterPro; IPR039901; Kdotransferase.
DR   PANTHER; PTHR42755:SF1; 3-DEOXY-D-MANNO-OCTULOSONIC ACID TRANSFERASE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR42755; 3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE; 1.
DR   Pfam; PF04413; Glycos_transf_N; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU365103};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|RuleBase:RU365103};
KW   Membrane {ECO:0000256|RuleBase:RU365103};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019063};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365103}.
FT   DOMAIN          28..175
FT                   /note="3-deoxy-D-manno-octulosonic-acid transferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04413"
FT   ACT_SITE        43
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639901-1"
SQ   SEQUENCE   396 AA;  42279 MW;  B8E5BE1585143C95 CRC64;
     MVKRPFSINT YFASTRGRAP VWTPDAPRPK GELVWLHAGS RAEARALETL AARLRQQRPE
     TGLLATGAWD EGAAALPPET PGDARLFLDH WRPNLCLWSG PTLNPALLWT AHEDGVPLLH
     ADDGQAPHVA PAARWLPDPV PATLALFDTL FVADAAAERR LPRASLSADR IRRSGVLQET
     TLPLDCDDDQ HEELLGLLAG RPIWLAARLR AGEARLVIDA HRVATRLSHR LVLVLVPASE
     EDGVQIAAAA DASGLRVSRW DEGETVDDGT QIILCQGAEE LGLWYRLAPL AFLGGSLVSG
     HGGTDPFEAA SLGVAILYGP NVGRHLAAYT TLVDAGAARI VRDEDSLAGA VSQLLAPDRA
     ASMAHAGWEV VSAGAEATDA VLARMVELLD ALRGRT
//
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