ID W4IBK6_PLAFA Unreviewed; 1125 AA.
AC W4IBK6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=SP-RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFNF135_05065 {ECO:0000313|EMBL:ETW40762.1};
OS Plasmodium falciparum NF135/5.C10.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW40762.1, ECO:0000313|Proteomes:UP000019114};
RN [1] {ECO:0000313|EMBL:ETW40762.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW40762.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW40762.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW40762.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the PIAS family.
CC {ECO:0000256|ARBA:ARBA00005383}.
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DR EMBL; KI926065; ETW40762.1; -; Genomic_DNA.
DR AlphaFoldDB; W4IBK6; -.
DR EnsemblProtists; ETW40762; ETW40762; PFNF135_05065.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000019114; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR CDD; cd16650; SP-RING_PIAS-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10782:SF4; E3 SUMO-PROTEIN LIGASE SIZ1; 1.
DR PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00452}.
FT DOMAIN 14..48
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 363..449
FT /note="SP-RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51044"
FT REGION 666..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 130068 MW; EC1B841450176D1B CRC64;
MTYNVNNTNM AEYLNKLRVY DLNQLCRKFL LPQHGKKVAI IERILQYITD VEREEQIYEF
ILATKPSIFE IINDKRMGTN ILHDSSKLFF SNSNYVRNDN NINVNCNNID KLAYASSDPP
STKKAASSTA RKGKVKIYEE DNEFSTCVCG GMSKNMSSKN GIVKCIECKK SQHVSCYIPN
TFINKDLSNY EILCIACRVK DMDPFYPMKK VLWMKNISTN TEKLMINASD IKQWRNENKD
VIVFCINLEP QNLKNTAPIK QEWPKTFNLK VNGNITEKIF EPSWEHKRRD SPLKITHTLK
AGINSIDIIS TNYDIPKLFV VTFALCKYES EQVIIENVIL RSSLNFKDAK DRIVNILSTK
HDSDEVMCME VNRKVSLHCP FSLDRILIPC RGIMCSHIKC FDLKSFIDVT KKTKAFNNRW
KCPICSFYLR PKNLVIDTFI TYILSQVPKD IKEIELSKQA EIIFNKNNQE PKVIKQLDDV
DTLDLQKKHI DIKNEYIMGK SYNEQKNNNS FNNDEIIILD SDTDDNNSTY NINCDKYNME
KNNNIIQGNQ EVICISDSDE ENVHEKNING KNISNDKCSS RINMIEYQDV NRRVNELLKR
NFLQSKSGTF VGSPEMFFNN IVLDVLTDFN NIHVNEISSI QDYDIMLKES TKTISNINKI
VNMTNDDKNI TSSTDSKNSS SSNFNKNITS SNFNKNSASS NFNKNITSSN FNKNITSSNF
NKNITPSTTN NIHNELDLSA VALLEYYSKK NNIPKDLSYI NSQLSPFELK PVENYINISN
SLDENNILIL DTLKKKNVDT SGVSIENQLD SITKSFNNII QGDNKNDNNN NNNNNNNNNN
DGNNNATTIN NNNNNNITNN SNYYNLSSCS DYNSNYDNDN LIPFDVFNIN EAHLSLDQTQ
QIIPSDTINN TENNNTSTNN NNNNNKNFYL KFEERFNMNN DRIITNKLPD ENNFQALNEL
NKELRNAHNL SIINYDNNNN NNNNNNNNNN NNNNKLNKKK KKKKNSITTN INKKNNNKIN
RSNNINNSYS SFRRIDSICN NFNFSMIKYS NKHNNNNNNN SNNINSNNIN NNNNKRKNTN
NKTIYQYINP NNTNQHFIKR LRKNKRISKK DKNLKENQKK KIKRK
//
