ID W4IX69_PLAFP Unreviewed; 756 AA.
AC W4IX69;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Diphthamide biosynthesis protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFUGPA_03809 {ECO:0000313|EMBL:ETW53936.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW53936.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW53936.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53936.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW53936.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53936.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005156}.
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DR EMBL; KI927384; ETW53936.1; -; Genomic_DNA.
DR AlphaFoldDB; W4IX69; -.
DR EnsemblProtists; ETW53936; ETW53936; PFUGPA_03809.
DR OMA; IEMYILL; -.
DR UniPathway; UPA00559; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0090560; F:2-(3-amino-3-carboxypropyl)histidine synthase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017183; P:protein histidyl modification to diphthamide; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.11840; Diphthamide synthesis DPH1/DPH2 domain 1; 1.
DR Gene3D; 3.40.50.11860; Diphthamide synthesis DPH1/DPH2 domain 3; 1.
DR InterPro; IPR016435; DPH1/DPH2.
DR InterPro; IPR042263; DPH1/DPH2_1.
DR InterPro; IPR042265; DPH1/DPH2_3.
DR NCBIfam; TIGR00322; diphth2_R; 2.
DR PANTHER; PTHR10762:SF2; 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2; 1.
DR PANTHER; PTHR10762; DIPHTHAMIDE BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF01866; Diphthamide_syn; 2.
DR SFLD; SFLDS00032; Radical_SAM_3-amino-3-carboxyp; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT REGION 88..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 90273 MW; 9FD122F943510412 CRC64;
MHDIVERYEL KLLINIILNN NYKNVAIQLP DCMLKDSLCI TNLLKNEFQK YNKEIIFNES
IKNNGSINRN DSECSPYCCK EKKNGEDLHT NEKKKNNCND NKMDDDKGNI KSSVHVDVVE
NNEHNNEHNN EHNNEHNNEH NNEHNNEHNN EHNNEHNNEH NNEHNNEHNI NHNNNNNNNN
KDKHVNLYIL GDTTLNECCE DYVSAEHVEA DFLVHYGISC QSFITPFIPS IYIFNKQNIE
DNFFHNIKQY LKNENVFKQN KTSIILCDAS FAHVLPELVR CFFDKIEKNN NICTDLKNEE
KKEINDSLSF YNYNNKVLYN VDDKMYVNKT FYEKGEDNYN ECNITDLKND NNRNNDDYYD
NSEDDMIFTN IIVCLYRIAN NINGKVCYGF FNNYVEFDIK DKIEDKYLFM CGRLVFKVFY
NMKKEMIVYK IVEKKKEERQ IYEENGDDEL INNKNMNLFI FSSDNKNFIN RCLLEYNNCN
NIYIYDSKDI FIKDTRKIID KVLLKRYSLI EKCKQVNNVG ILISNVNLEK NKEIRILINY
ILRKNKKKCF TVVTNKLNTA KLENFYDIEI YILLTCPENN LLELKEFSKK IINPYEFFIA
YNYIEWDGKY VFDFFELLNI SSIKKEYQAI HNNKYFLWNM DADFFTIKNH HKDNKDNNDE
NVNVIIQQNN LVLEKYDHLI DTNLSISVED QKKFITRFQE DSQMCTYFLN ILKENNKREY
KGVDINYNTD HVPHIVKGLY GIAQKYDTDI KHLKEQ
//