ID W4J0C2_PLAFP Unreviewed; 1695 AA.
AC W4J0C2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA repair protein REV1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFUGPA_02863 {ECO:0000313|EMBL:ETW55041.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW55041.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW55041.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55041.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW55041.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55041.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; KI927382; ETW55041.1; -; Genomic_DNA.
DR EnsemblProtists; ETW55041; ETW55041; PFUGPA_02863.
DR OMA; HFCIFIM; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03468; PolY_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00817; IMS; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT DOMAIN 235..310
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 667..829
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 148..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1497..1527
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 150..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1695 AA; 202774 MW; 444CE1B17190C3EF CRC64;
MDIEYGGARD FEKYICNKEE KIPLSYNKKY LAEIEESHKK CKNDSLLFMN CNFYIDDFVS
FFSICNTLDN SNTQTKCIYR NEKDSVEDSK ELNNYMNNNS INKTTLGKFN MENKMEYNYT
SINEHNNNNY YINKIHNDSV FKYQDMDKTP MKNNIDNNSN NNNNNNDNNN NNGNTYLYDN
YLEDQFNQTI KNRYSCTPND QISTCTKSFN TCIKTYEEQA SSSCKKNVYN SYINKKENLE
ILIVQNGGVI HNTLTSKVTH IISNNMALGS KKYMDYKKAI KKSKVFIVID QYIFDCVNMQ
CRLPEQSYLP SMLRYNCHQI TEYFSLRKKD KEQNKKMQNK KIQDKINNDQ NFLKEHKEGE
QNNVTILDTS KCDKQLNDYY VEKKLSTCHN KTSVNNNLNK TDMYGTKEDN NLLIHKDIGN
NENLNYINEQ KVPEENNNEE KKENITNNDN INKHLEILNM NMDYEHVKKF IICNSNEYFK
RLQEYYLEKE LKENIYSNVS SNLYLNKNTF EDFCRKYRIL NYLSDEEIKW LKCKSELNIN
IKNLWENDII HFFFDLVLRK KEHFKNNTVG NNNIGNNHNI GNNNNIGNNY NIGNNNNNIG
NNNNNTQSYT DINKSSSYIC ENLIESISAY LYNSRLYILG NWNYISKELF NFDDIKEYEK
GSKKFVYLYI DFDNYFLNAS IRNKICMYEK KKSMNNEIFC VCHSLKKEDS YGIISSTNYW
GKKNKILKGM VKGEATKMNK NINFVKYDFS NILKCSYLFL LVLINYSKNV RVLSVDESIL
QLFYEKEEDI FIISKKISDD IYRLTNLSVS IGISHDLSTS RKALKFCKKR FMFFDFYHHF
NIFIKKYISL KNKESNITPE ASNDDNIKSN TISDDKIING KLKHMIEQNK NVNGTNNTDD
YRTNWMSDDK LKDLFKEYLS FEKKRKSELK YNENNKEKYN MNIDNIYFMN LIKGKREKEV
EYIYNKFLEM NKENIEQMVN TYFEEVIHPV STYFFFYKPN EYYFNILKNM NYLNGYFISF
NMYYLPHIEN DSNNNNNNNN NHHSNNNLHS NNNFHSNNNW LNNKMDRNIN KKELENNDEK
KSINISVNYG VRFNKINDFY YLIYFMTKQL YLRLKIKNLK AKLLHVNFFI KAENENVNPM
KYLGRGRVIR ISSKIKLNQH TNCFFVYFFK VIHTFDFLAN NLSDLRGVQI ICSDTINENK
THVNKKSILY YFYVNTEKNI KNKKNCKYVA SWKDDNFLEV PQKVNDKDQV QENVKDPHQI
NENKIHLHNI MLSSQKKNET NKKETNGKIS KNNINSSSIL SYIKDKNKGT NILTSQINWT
HSNNNNNNNN TYSRKEIRKT VRKGTSTSIK RKIKNKINTH IRYDKNIRNN KLYHYEYKQN
ILNYFVHNNH NSNRTQNLIH KKENNFQNNQ NVSLCSSSKT INKGFKRKCN ILRSNANFLN
IRKKIKITKN YKISDFFPSI LKKKIYIRNN KNIYDDEIKT YGNGNIIMHT NIFDSIINKK
IKKENDEEND EENEENEQNE KNEKNELCDK NYHMKKQFTC CYFCYKEITQ YLVHKEKLFE
ENHKCNDLCR NDIFCFTYIC NNLFLFNHTN DKLNLYLYIK KIINSYRSYF HNTFEEHDCV
CNNTLKKDQE NIYYLNKFMV KVIDDICEML HKKRYIDVLQ NFLKNFKYVW SLNNELFPEI
FQRILIKYNI NHMTT
//
