ID W4J4G3_PLAFP Unreviewed; 2172 AA.
AC W4J4G3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN ORFNames=PFUGPA_00912 {ECO:0000313|EMBL:ETW57135.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW57135.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW57135.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW57135.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW57135.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW57135.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927283; ETW57135.1; -; Genomic_DNA.
DR EnsemblProtists; ETW57135; ETW57135; PFUGPA_00912.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037831; SNX17/27/31.
DR PANTHER; PTHR12431:SF14; LD15323P; 1.
DR PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 289..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2107..2126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..130
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 516..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1394..1459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2034..2089
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 516..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..670
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..712
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..826
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2172 AA; 259098 MW; DAB5DD4B0F83CC33 CRC64;
MMESYSTYEF KDNLIIKIIR TNDVKKRFYS YTEYILEFKV LNSQKVLKKR YSDFVTFYDL
LKNELLTKFS ESLEKISVLP SKKIFGRFNY NFIEERRQQL ESFLMNITKY KNVYLCDNFY
EFLCLDNITK YLYKLMCTRL EDICNIQKLL KKINYILFMS RNNTLKSAEC DIINYLYYLK
ENIKLNNEIK FFILNIFLHH LTYTKTSENL LNVSLMRFSF DIIYENLLSN SINEVLLKTS
SETILRIVDK RSDVFLDYLK IYNFKQICII FNLINKKKER KDNKKIDNIV FNIYILISLL
LLSSIHIKDI QNFFIIKNNN NNNKGLRILG YMYESQNINI QIICCIILSL LIINKTIKDD
DVIYKTKMSI LLIQNDLQNI KSVDYQLIEI ICSKKNINLL NSILDLLLKD KILKYDLTLN
DIEHYEKCIM YDNPFEKDLF YEQKIKYADF LNNDIILQFI LFIINIGVTE FFLLKKNYKF
LMKKKKLKIK LKKKELSEKS KLRKINKKTK QAQYMLTDKG QDYNTSAQNR NKNINKKNKS
QPKKGQEYMY MSKYCNAPVQ DDDDDDDYDD EYDNGFKGRL EAERSKNKKK QLYENVDRDE
YEDEDGDENY DEDDENDDEN YDEDDENDDE DDENDDEDDE NDDEYDDDDE NDDANDDDDE
DDDQYDDEDG YYDSHYDNAE NFNVGVKGKM NRKINKRISN KKNKRMNKKG KKKKKDIEPS
NASATSSCIS SLYSFSSDYD SATNNNNNNN DDDDKDYKDY NKKNKKNYVL NLNMHVVKNI
SYDDDFSVHS GSIGNDLLFL EGEGSENGDV DSEDNDDNDD NNYNDDNNYN DDNNYNGNHN
NNCGENLNKK YKNTNKKSSE KKNISNSSKY NKKNVTSSEL REEIKMLKEN RKKFVRRIRR
INEQILLILC NEKMIHNIYK CANLNNYKIK FYASVILSYI PNINEMISNF SNQDYLNNRS
MDSNIIINND NNKNDDNKNN DTNNNNNNDN NNNNNNNNNN NNNLNDDVYP NRFYKNLNNV
YNMNHEDCVN NDNVKCFVDG EKDKNNLQYP YYGPIENYTK SSFASDSLAI RKNSKIFICS
VEGDYYNYIY KFNIFNVLLY YLFNETYFYE HILVHLKKYI EEQSSLMNLK HFKIKKNEFT
NTLFFNTLGK NMEKKNKGKN IKKNRNKKIY KKESFLSTTD KTNTKPKGPM TYGYKNNYGN
NSYYNDSTHL NYMSKKNNVR VGECLIKNNK IGYDNNNESK DNIKENSGDM ENSLVEYTPN
NSVFGEVQSI HNDFNNIKMN NLNNVNNVND VNNVNNINNV NNVNNINNVN NVNNINNVNN
INNVNYCEEN KTNYNNGQIV LYSESKIYDH MHHVFNYISN IRKFGLLNNY IVELYMSIRK
KLMNIDMGFL FDLLEKKVLE KNVMKDMINN LKKEYEYVNI TYNDYINLQY ECNKFINIMD
KLYEELDDIE KRRKKILRSH KIVHVNVCNY RKKLIHIEKM IEEAPTMKKC INDELYKIKI
NVGLYKKDRK KLSFFILLHK FYLDNYNIVI NKLKNMNNLI ENIELLSSTE YEKNKSLIFN
ELSYLLCNDV ILIEMLKKKC KIEVAKNKNY SLLLAREKKM DTFSYNICNE NKLIIINKDN
VMSDRKNMDL FKVKDDILDK YAYYFNNDNV LNMDHHMQTQ YNRSFDKMKN VKGVKNVKNV
KSVKSVDNMY NVDNMYNMDN MYNMDNMYNM DNIYNMNNMY NMYSINNNAY DMYDMSNNSY
KNMQNNFNDK SSDSDDIVAN KLGKKGQGII QNVFNHKNDY YNNRGKTNSI YNFDTTLEDF
NNNNIIKDNK VILSVDEIGV EKNVKMNEKR ESTDHNYHDE NYKRTNYYNK NYRDDMFNES
NEKDKMMMLL NDDQNEDSVP VELDEGNVEE EDEEDQGHHH DEDELEEDTL NTEFVSSDED
NIDLKKRIDE FNNYKNDNIK GLLPEDIKVD DTITKKRFLE IFDIIKNRKK QIEKMTTHQN
SEIYKNIHKY NTLLNKCNMQ INFNQKRYAK LRKQMASINT STMIKKSESI YKTIREWDDK
INLLNDDIKV VENEKKEKEK EIAIQKKKLD KKEKEKNQKK EELRLLVTEM YKHNNKIKKK
YKKDEKIILL ILYNSWFLYH YIYIIYLNTI KLKNFLSYKQ NINEQCLSSA KQTILNINFF
SELLDENDCQ LF
//