ID W4M3S0_9BACT Unreviewed; 329 AA.
AC W4M3S0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha {ECO:0000313|EMBL:ETX05004.1};
GN ORFNames=ETSY2_25545 {ECO:0000313|EMBL:ETX05004.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETX05004.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETX05004.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETX05004.1}.
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DR EMBL; AZHX01001066; ETX05004.1; -; Genomic_DNA.
DR AlphaFoldDB; W4M3S0; -.
DR PATRIC; fig|1429439.4.peg.4337; -.
DR HOGENOM; CLU_029393_5_0_7; -.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000019140}.
FT DOMAIN 13..314
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT COILED 274..301
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 329 AA; 35714 MW; 8F02224AA0995F2B CRC64;
MALDKALLME MLRRMVRIRL FEEEVIRMVE RGEIPGAAHS YIGEEAVAVG ACLALRPDDW
MTGNHRSHGH PIAKGGDVKK AMAELLGKRT GLCKGKGGSM HLADFSVGIL GESGILGSSI
PTAVGAALGS RQQGNDRVAV AFFGDGASNE GAFHESINLA AIWKLPVIFL CENNQYAVTS
SFKDMVATEN ISDRAAGYNI PGVLVDGQDA IAMYEVVSEA VQRARAGQGP SLIEGKTYRY
YDHSLGLGRI VRAPYRSDEE VEAWKQRDPI GIHKERLLSQ AIATQAELDQ IEAEVTQEIA
EAVAFARESP YPEPSELFED MFANPIPLD
//
