ID W4P363_9BACE Unreviewed; 1057 AA.
AC W4P363;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=JCM6292_117 {ECO:0000313|EMBL:GAE14040.1};
OS Bacteroides pyogenes JCM 6292.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1235809 {ECO:0000313|EMBL:GAE14040.1, ECO:0000313|Proteomes:UP000018861};
RN [1] {ECO:0000313|EMBL:GAE14040.1, ECO:0000313|Proteomes:UP000018861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6292 {ECO:0000313|EMBL:GAE14040.1,
RC ECO:0000313|Proteomes:UP000018861};
RA Sakamoto M., Oshima K., Suda W., Kitamura K., Iida T., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequences of Three Strains of Bacteroides pyogenes Isolated
RT from a Cat and Swine.";
RL Genome Announc. 2:e01242-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE14040.1}.
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DR EMBL; BAIQ01000001; GAE14040.1; -; Genomic_DNA.
DR AlphaFoldDB; W4P363; -.
DR Proteomes; UP000018861; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..465
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 488..735
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 858..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 9..16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1057 AA; 122402 MW; DD39E227A23A73C8 CRC64;
MSELLVYKAS AGSGKTFTLA VEYIKQLILN PRAYRQILAV TFTNKATAEM KERILSQLYG
IGTEDKDSEA YLQRIQEETG LTKKEIREAA RTALGYMLHD YSRFRVETID SFFQSVMRNL
ARELELSPNL NIELNNSEVL SDAVDSMIEK LEPSSPVLAW ILDYIGERIA DDKRWNISDE
VKSFGRNIFD ETYIEKGEGL RRQLQHPDAI KEYRKQLKAL ETEVLEQMKG FYEHFEEELE
VHGLSAEDLK GGKNGIGSYF RKLRDGKLMN KDVLNKTLEK CLEDSKEWAT KSKPRAAEII
ALAESTLMPI LKEAEKLRSK NNLLLNSCRL SLQHLNKLQL LAHIDAEVRL LNHENNRFLL
SDTNALLHRL VKDGDSSFVF EKIGTNIRNV MIDEFQDTSR MQWGNFKILL LEGLSQGADS
LIVGDVKQSI YRWRSGDWGI LNRLNDRIDH FPVRVKTLDT NRRSETNIIR FNNRIFTAAA
DYLNGIYKEQ LGEDCEDLKK AYADVEQQTP RTVDKGYIKV SFLEEDGERD YAEQTLISMG
KEVERLLSSG VRLNDIAILV RKNKNIPRIA DYFDKELHYK VVSDEAFRLD SSQAIRILID
ALRYLSNEEN AIARARLAVG YQNEILQKGA DYNTLLLSPA ENYLPPEFPE RKDELRLMPL
YELLEELFSI FEIKRIEKQD AYLFAFFDAV TEYLQSNSSE TDAFIRYWDE KLCQKTIPSG
EVEGIRIFSI HKSKGLEFHT VLLPFCDWKL ENETNNQLVW CVPQQAPFNA LEILPVNYSG
TMAESVYGND YLEERLQLWV DNLNLLYVAF TRAGKNLLVW SKQAQKGTVS ELLARTLPIA
AQKEGACYED NQYEEGEICP SEEKKSRTST NKLTREPEKR PVRMESVRPD IKFRQSNRSA
DFIQGVEEEE SDDRFINRGR MLHTLFSAIA TAEDIDGAID RLVFEGVISS REKEEEIREV
ARKAFALPEI QEWYSGGWRL FNECAIIYKE RGVLQTRRPD RVMMKDGQVV VVDFKFGKQN
PKYNKQVKEY MRLLARMNYK NITGYLWYVD EERVEKV
//
