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Database: UniProt
Entry: W4Y7I6_STRPU
LinkDB: W4Y7I6_STRPU
Original site: W4Y7I6_STRPU 
ID   W4Y7I6_STRPU            Unreviewed;      2469 AA.
AC   W4Y7I6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-SEP-2017, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_011692-tr};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_011692-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_011692-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_011692-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AAGJ04172492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04172493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04172494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7668.SPU_011692tr; -.
DR   EnsemblMetazoa; SPU_011692-tr; SPU_011692-tr; SPU_011692.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     34     49       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     70     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    434    452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    464    485       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    559    582       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    669       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    681    705       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    808    826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    846    866       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    875    893       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    946    965       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1081       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1129   1152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1164   1182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1247   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1353   1375       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1515   1549       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      717    739       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2469 AA;  279554 MW;  706F71ECB0E464C3 CRC64;
     MAALTTGATP YSDGLEVNFG GGPAREPPPP SPEYFILATI IANCVVLALD THLPKEDKTP
     RSIALEDTEI YFLAIFCLEA GIKIIALGFL LHEESYLRNG WNIMDFIVVV TGTVSVVEAS
     NATQSGGFDL RTLRAVRVLR PLKLVSGIPS LQVVLKSIIR AMAPLLQITL LILFVIIIFA
     ITGMEFFMGK FHQTCYVFDP ISGNETREIA EDNPQVCGYR QCGDFENCTG YWDGPNFGIT
     NFDNMLYAML TVFQCITMEG WTDIMYNCND SEGPQFVWVY FIPLIILGSF FMLNLVLGVL
     SGEFAKERER VENRRAFLKL RRQQQIDKEL MGYLEWICKA EEVMLNDKSI SEEEREAIED
     RRRDAATRTE DLGNGKPSGA DVASSYDLDT DKDPNSNSPT KEKKKKKRKK KFVRIRRAEK
     RLRFAIRHAV KTQAFYWLVI VLVFLNTICV AIEHYNQPHW LEQFLYYAEI VFLCIFIMEM
     VIKLYGLGPG VYFQSAFNKF DCIVICASMF EVIWTKYKEE SFGLSVLRAL RLLRIFKVTR
     YWTNLRYLLI SLVHSIQSIV SLVFLLFLFL VIFALLGMEF FGGEYWSSLR NLVISLLSSM
     RSIVSLLFLL FLFILIFALL GMQLFGGSFN YDATQAKPSS NFDTFWIALI TVFQILTGED
     WNVVMYQGIK SQGGVPNGMW ASIYFVILVL FGNYTLLNVF LAIAVDNLAN AQELTKLDQE
     EDEENRQAAA NELLELQAQQ TPNMSRRGSP NPDNPSIKKA NNNKEQEAED ENDESFHPKP
     MVPYSALFIF STTNPVRRFC HYIVTLRYFD TMIMVVIALS SIALAAEDPI DPDNKRNKVL
     EYFDYIFTGI FTIEMVLKIM DMGLLLHKGA YMRDLWNILD AIVVVCALFA YAYRGGGTSG
     GPQQLNTIKS LRVLRVLRPL KTIKRVPKLK AVFDCVVNSV KNVTNIAIVY LLFMFIFAVI
     GVQLFKGKFF HCSDLSKVTE EECQGRYFLY EGDQIKESAD RVWDKYEFNY DNVALAILTL
     FTVSTGEGWP DVLKHSIEAT EEGMGPTPYN RIEMSLYYVV YFIIFPFFFL NIFVALIIIT
     FQEQGDQDFF DGEIDKNQKQ CIEFCITAKP VDRFMPENKN SFRFKVWKLV VSSAFEYFIM
     TLITLNTFTL MVKYHGQPEI YSAILKNLNI AFTVLFTIEA MLKLTAFGIR NYFKEGWNTF
     DFITVVGSVA DVIISEVGDG FINLSVLRLF RAARLIKLLR QGSSIRILLW TFIQSFKALP
     WVCLLIWMLF FIYAIIGMQI FGNIAPIDGQ QINRHNNFGQ FFSSLLLLFR CATGEAWQSI
     MMSCLPGAAC ADPDPNNLSG IKEFDTCGSY FSYVYFVSFS FLCSFLMLNL FVAVIMDNFD
     YLTRDASILG AHHLDEYVRI WGDFDPVGSG RVLYKDMYDM LKNIEPPVGF GRNCPYRIAY
     KRLIRMNMPV DENKMVQFTS TLMALIRTAL DIKIGSVADR DRHDAELREA VKCFWPHLSG
     DKLDLLVPPD SELIGEKLTV GKIYAALLIY ETWREYKAKI QRDGHARTEL VYFKYLYKKY
     PGFDINDERY QNTFSDEFRR RPSLFRRLVG AVKKNSNENL PGLAEEGGST SGTVAIKEEK
     TPSPPPKEKE RPRPGKVVTT LPRIDSSGSE GLMVDQPLKQ ASPKQAERYQ RKGRDPDRES
     RHHRYREPPD NSRTLPLDPS EDCVAPVSGN TDLGLLDLGL DLTGVAQSDQ DEFLMSQSTN
     MTSIYGEYDN HSYEYDEEEE EEVDLGVEGT SALEEQEFED DKAIEMSDIR YRDRDERGKG
     GPVDRRERHS MDKHAIQYSN NTTGGNTPYS HSDYSLARGG TGRERERDRE RSSERARPRV
     RHSVAISSDE VPFSDRERFS EERRHYPERD RENASREKRH SLPPVNNFDQ MERPRGRPPQ
     SMSQGGLSGR SGSSDGHGST GNKAIDAILK KGSDIRAQNR QDPTGHGQTP RDGQPRDGQP
     RDGQPTDRER KMGIPRQRPR QGSLPAPPIT GSHSMPAFDD GRPTRQRHSV GSPSMPDFQG
     RGTPRQPGGG FTSTPAGDDR RDQRRPSGEP SSRKRSNRHD DALIDTRPPQ QDIIPEEDEG
     VPPDGSDVLR RTARNNRKNS GGHLGQYQKF DNSLDSEEPP SQAPGQDVRG ERDTVEGSYY
     NEDAVSSNNR ASNYARPTEG ASSSSRHERL DSEDSVSSSQ PLLSPGRSPS PRRRAPISTR
     DVSPQRFPPS HSPSSRRRDR HRGPDYVEFH DRDMYDEPSY DDPFGPERSG GSSHRRPSPG
     WREPRDLLQA GPSQSRASSS ERMDPESSQS SPPSRKHTGR RLPTVPGETR GGGGGGGGGS
     VTPRQRQRPT VPRSRDHSPM RLPPPQHGGR NSGGGSKGDV RLQMDERPPH YDVVMRTQDA
     PSPDQHVDPR MPNGFRPGGV EKGRGHGTQG HSPRRTPQGV PRGPGRKHVT DNGQGGNGGY
     SDTEEDEWA
//
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