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Database: UniProt
Entry: W4YAV6_STRPU
LinkDB: W4YAV6_STRPU
Original site: W4YAV6_STRPU 
ID   W4YAV6_STRPU            Unreviewed;      2657 AA.
AC   W4YAV6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   10-MAY-2017, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_012877-tr};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_012877-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_012877-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_012877-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|SAAS:SAAS00546352}.
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DR   EMBL; AAGJ04005820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04005826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7668.SPU_012877tr; -.
DR   EnsemblMetazoa; SPU_012877-tr; SPU_012877-tr; SPU_012877.
DR   eggNOG; KOG0244; Eukaryota.
DR   eggNOG; KOG0500; Eukaryota.
DR   eggNOG; COG5059; LUCA.
DR   OrthoDB; EOG091G01NE; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008574; F:ATP-dependent microtubule motor activity, plus-end-directed; IBA:GO_Central.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 4.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00100; cNMP; 3.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF51206; SSF51206; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 3.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00784251}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00785115};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM   1260   1284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1296   1321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1341   1363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1408   1426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1485   1510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1805   1823       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1829   1848       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1943   1960       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2037   2062       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2484   2503       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2597   2615       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5    337       Kinesin motor. {ECO:0000259|PROSITE:
FT                                PS50067}.
FT   DOMAIN     1114   1164       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN     1591   1691       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN     2140   2240       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   NP_BIND      84     91       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00283}.
FT   COILED      345    372       {ECO:0000256|SAM:Coils}.
FT   COILED      646    701       {ECO:0000256|SAM:Coils}.
FT   COILED      716    747       {ECO:0000256|SAM:Coils}.
FT   COILED      779    827       {ECO:0000256|SAM:Coils}.
FT   COILED      848    882       {ECO:0000256|SAM:Coils}.
FT   COILED      904    931       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2657 AA;  301659 MW;  E3E2C8FFBB9807D0 CRC64;
     MQECPVRVAV RVRPLLAQER LHHHELCVKV NSKANQIVVG KDRAFTFDHV MSSKTSQEAI
     YQTCVDNLIT SFFEGYNATV FAYGQTGSGK TFTIGGADVI NIPENEQGII PRAIGHIFEN
     IQNNHNRDFT IHVSYIEVYK EDLRDLLDME TSSKDMHIRE DDQGNTVILG TSEIPCSCMD
     DVLRCLEIGS THRHTGATNM NEHSSRSHSI FTILMEDELS DEEDDGQDYH FMSAKFHFVD
     LAGSERAHRT GNAGERFKES VYINSGLLSL GNVISALSDP KRKATHIPYR DSKITRLLKD
     SLGGNAKTCM ITCISPSAVN FDETLNSLKY ANRARNIKNK PIVNKDKQAT RIAEMQTEIQ
     ALRDELQRHR LTTANTEVGP DTLRVQDLEE QIARLRNELS HFHVCTDEAS KIFTGFQDSD
     RLTKAQRTAV NNWMDLASEM KDAVRSATPL DPARYGQVEG QEKTLELESK LKQTGGGAFE
     LPLSAGRRAM SVPPHAMRTK SASGSNTARD RRPEARRLHT SPPLFSLERI VQGFRARSQL
     LIRHLEDNDA VLQESLTDSS GPEDSDTETK ALGQTWSKEE RGGSSSARQI RRTHIKNNKV
     ANGTLTKSRA GQDTPSEAVD LRSSVEAGHE RVRASQRNMQ ESHHKLRDLN LNIKLKEELI
     RELAKTSKES EAANKKYSNK IKLLEKDAQK ARQELMEAKR HLHGLGSKGE MESKEKNKLE
     DEYQKKMEKA HSKVKELMKK QQESERVLKM QTQREKKIED LEIAVGRMKQ HQELQQARLR
     EEGDRKLKLE RDLQRDQQRI KELEIKNDQQ QKILKRKTEE VAAAQRKLRV GSAHAPDHDK
     VEEQRKWLDT EVEKILQRKK KMKDLEEELK KREVNLAKKE SMLREMGELE MRKLRSSQSI
     SRDMTGLASK LESVEREIEE KNNTLRVSLD AQKPVIGREV QALREERERL LHQRIHLDEK
     LQQGTLLSAT EERRLIELDE GVEALEAAIE YKNDVISTKK KDLRRNDLTQ KDQSVPEDLQ
     KQVIGYYEYL WVRKKGVTDD SLINALPLTF HAEVSLSGNK YILDKAPMFQ GLSDGFLRML
     SLEIKPSLYL PRQKIAGRNE ICHDMYFIQR GEIEVSLIFS MPRTNTIRAA AHCDLLVLDK
     GDLQNVLLHY PEVAKKLQDI ADQRCDAAGL LEERVRAGEG IIPASKSLSR HGNPQNKHDS
     AYPLNSYEAF DMEDVESEWV TVHRGSVVMR TGRHLRILWD DIQSLITDTV VLPNSRFARL
     WELLVLLVTL VIAFLYPYCA SFIANQNRND EGTENLILLT HMYLMDFVLV IDIVVRLRTA
     VTTPNGTFKD FHYIRDHYVR SWGFVADVVA ILPLDLFCLL LPVGIQRTHA LYLLALNRLI
     KCWRVPNYLQ NLEQNLDVNI GTIRFFKFVI YIALLSHWSA CLWYLFACPS GNDDGAQAAP
     AVDMPVDEVF TLPSHEYIQS LYWAAATMTS TGYGDISAHS TIGRAIALAA MLVGLLLYGY
     CLSSIAATLA NSDAPRVGFQ EKLFAAQDFM KKHNLTPDLQ QRVVNYLSLV FRRHRGEAIP
     GGERVMHDMP IQLQQDIAYQ DVHETLSKVP LFKECDSNFL RMLALKLHVF IFMPGDVIVY
     QGDMGREMYF IRRGTCEVLS KDGNHVMSNI GPGQYFGEVG LIFGDYRTAT VRAASYCELL
     MLKRVDLDRV LKFFPLIEKQ FSDAARNQGH LRELRDASKV DKKPVEFTPG TVLEPEDDED
     SEDMSLYPAA TSLRPVDISI KIFDKKSEDF QEPFQEISLL SRLFAKLLMS RAFIPNGTCF
     KRWEAIRVAV AILAAFTVTL QAAFLHMNIG LWVVTYGLDF ICFVDMYLKF HTAFYNESNV
     LVTHPLSTAK HYLRTNFLID VLACFPTELI AYALIGNFSQ EAIHVYALVR INRLLQLYRV
     PLAFNYLESD VQNLTGNIRM MKFFFYMVLF IHMLACMWYM NACPPVFKYP ITGETFNGFI
     TTNFHRCKNN SWTSKTDTSF YDQPIAAQYV TSMYWASATG ASVGYGDIHA NSVSEMILAL
     FSMIVGIVFF GYIIASVAAS LANADAQRAR YQEKLTAIAR YLKDQRVEKS LAQHVDVYYN
     YMWLRTKGVE PDSLFDGLPL ALKADVSLNL YQGIINKVPL FTNTEIGFQK MLAMCIKPVY
     YLNREYIVRK HDFGKEMFFI HRGLVEVVSE DGSIVFDTMQ AGRFFGEISL VFSCPRTASI
     RAQNNVDMFV LNKEDLDEVL THYPSIKDQI NKVAEDRITA VRKRSEAKVD QASNTPNNSN
     NNSIKGSSFN SIEKSENSTA SASSSGHPSC SSTADNASSQ TKPEDGHSTG TAAAASDNRS
     EPESPSVSST AATTPTSTEP PPPSAAPMKP ARQIPQPNAN NNASTGEGSG NNNNQGGNNA
     SNTQSDPSAP DSSSSTTHVP TRYPMPFCCI RRDKNYLEAL LHANRFVLNP DSPVVRNLAR
     LTCVLAVATS WTIMYQAFYQ VQSMPFLIFS YVCECVFIFE IYIKFHVSNA DEYGALEKDF
     GKIYKSYLRK WSGFAQDLIP TLPIELFAFL AQGDKQFAVL SFLRFRQVIR LMRVSQFFDR
     WEQELNINIL KVRLTKFLVL LLIIIHLFAS IWYTIACPLS NCKNGSWATM MVSGLVRKQR
     VKEELKEFDY ERLASWT
//
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