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Database: UniProt
Entry: W5IHG9_SCAIO
LinkDB: W5IHG9_SCAIO
Original site: W5IHG9_SCAIO 
ID   W5IHG9_SCAIO            Unreviewed;       572 AA.
AC   W5IHG9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF9020_00093 {ECO:0000313|EMBL:EFG26474.1};
OS   Scardovia inopinata F0304.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Scardovia.
OX   NCBI_TaxID=641146 {ECO:0000313|EMBL:EFG26474.1, ECO:0000313|Proteomes:UP000005777};
RN   [1] {ECO:0000313|EMBL:EFG26474.1, ECO:0000313|Proteomes:UP000005777}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0304 {ECO:0000313|EMBL:EFG26474.1,
RC   ECO:0000313|Proteomes:UP000005777};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA   Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Heiman D., Howarth C., Larimer J.,
RA   Lui A., MacDonald P.J., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Scardovia inopinata F0304.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFG26474.1}.
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DR   EMBL; ADCX01000001; EFG26474.1; -; Genomic_DNA.
DR   ProteinModelPortal; W5IHG9; -.
DR   STRING; 641146.HMPREF9020_00093; -.
DR   EnsemblBacteria; EFG26474; EFG26474; HMPREF9020_00093.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   Proteomes; UP000005777; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005777};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005777}.
FT   DOMAIN      261    397       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      475    544       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     269    276       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   572 AA;  63502 MW;  8BAA0DB7C35E3412 CRC64;
     MMGGIMTDSH NAVEFDAQRL WSFTQEYMES QGYLSPRDTR LVNEIHALGL FDNMIILSVN
     SESTRSILEN KLHTDVIECL SAVAGQTMTF VIKVEKPEDA WSQNDQAEAA DQINQADNDT
     NNKKGTIQAH PNFSPADHAV QDQSLPDLSQ EKRQNPQNEF RRNEVDSVKP DRRTYQHAHY
     GQHAIPTQAS LSLSPVSDHI RKSNQGSISA GSAEVSKNLE ARNAVTHLNP FATFDTFVQG
     TSNRFAKSAA VIVAEAPGTA DYNPLFIYGG SGLGKTHLLN AIGNYVLQQD PTMTVRYVTA
     EEFVNDFVSA LAAGARKQAA LANFTKKYRN VDVLLLDDIQ FFRGSETMEQ FFHTFNELTS
     TGKQIVIASD VAPNNLKGFN ERLRTRFNKG LVVDVAPPEK ETRVAILRLK VSNSNLAVPD
     DVLDYIADKI TDSVRELEGA LTRVTAIATL NDQQVTRTLA EQTLHDFFNS DVEVTPTSII
     TNVAQHYTLT FDDIVGPSRT KNVAEARQVS MYLIREMTSL SLVDIGEIFG GRDHSTVMHA
     CKKVAVEMGK KRTLYNNVND ITMHIKQSNS LN
//
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