ID W5J4J4_ANODA Unreviewed; 1868 AA.
AC W5J4J4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=AND_010061 {ECO:0000313|EMBL:ETN58338.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN58338.1};
RN [1] {ECO:0000313|EMBL:ETN58338.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN58338.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN58338.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC010061-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02002138; ETN58338.1; -; Genomic_DNA.
DR STRING; 43151.W5J4J4; -.
DR EnsemblMetazoa; ADAC010061-RA; ADAC010061-PA; ADAC010061.
DR VEuPathDB; VectorBase:ADAC010061; -.
DR VEuPathDB; VectorBase:ADAR2_011490; -.
DR eggNOG; KOG4231; Eukaryota.
DR eggNOG; KOG4553; Eukaryota.
DR HOGENOM; CLU_002204_0_0_1; -.
DR OMA; GPFKPLP; -.
DR OrthoDB; 1210920at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd11720; FANCI; 1.
DR CDD; cd07211; Pat_PNPLA8; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026171; FANCI.
DR InterPro; IPR029312; FANCI_HD2.
DR InterPro; IPR029308; FANCI_S1.
DR InterPro; IPR029315; FANCI_S2.
DR InterPro; IPR029313; FANCI_S3.
DR InterPro; IPR029314; FANCI_S4.
DR InterPro; IPR045217; PNPLA8-like.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR21818; BC025462 PROTEIN; 1.
DR PANTHER; PTHR21818:SF0; FANCONI ANEMIA GROUP I PROTEIN; 1.
DR Pfam; PF14680; FANCI_HD2; 1.
DR Pfam; PF14675; FANCI_S1; 1.
DR Pfam; PF14676; FANCI_S2; 1.
DR Pfam; PF14677; FANCI_S3; 1.
DR Pfam; PF14678; FANCI_S4; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 1514..1713
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 1222..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1868 AA; 212888 MW; 56AD0636C45D35A5 CRC64;
MPPNLVAAII ELGQKRKNDE LKELLEKTKS KYLIDLVVSN LQSIDGQTLW HYTLLGLGYS
DACREKRFEL IMAVLRHTNV VELSTKQMFD LIARLLTDLP TFSSEQLVEM CELCIESIRV
GDPKCLSWKH LLPQTLAQLN DSVGRFNANG MLLTGTDYRI KVLGELFKMK LLPAILTPLC
AMFRDFNLSR EETATFVTKI SDSIKQIEPL ELPPLAFQLF RVCLKNPGQL IVPLMALQKY
FHKNYYKKVL SNANSDTTDF DSIDRYSDTE IREAEETILY HLSNVTEFRL DETQTVAMFK
PFQNNPEKLL TPFLVGALLA MSRINRLPDT TDVVSSPIMA FLIKLIALSE KEREMCNQSA
WFRGRVDSSI GSRVDQLFTV LTENSQEGKE VVTPGIIHFA FALLLAKKQP KLHGIAIQFF
QIFLKRRFIF GSGIIAKLKK FLFADLEETQ FNLCLTTLSL TNTLTVSESS ATIQFIMEYL
LLIDGTYAMR FMAFLFPLLR LSHTIRDRFI EVLRKAMYNS ESCTRIMGVF GFCSLLKQLK
NNNARRSIMG PAGGNYTQLS ISGMSLLSQA AYGSASNPNL HFDMLTLEVL GILRKCLTQT
VEVRMMLYEA LGRAVDFNTM LLPHVLQFID WHFESYFNEN TDDKLSIAFD KCVRYRNDIE
HEDQPDLLRP IVVYDNVGRL TAFMVHCVVL CDHHNILHDT NAVKKTLQLI VDRVDSITFD
ELGIMGSLDT RAVEIASQYL NVIEAAMAYS AWKMKPDNGL SRDLLRLFKH HQQCVEKFKK
LEPKKGNKKH MIDMMNVSGY HGSSAKHGIS LKLENIWDIA TVERMLRIMF DISINYAREE
DLKTLRSNRD FQQYILKTAI HMMETLRTLP DYWQVSHSKR TFSHLCECTK VVYGRCVRQT
TDLCGNGGLL VAQSAIECFR QALLSALELY ERKFTEFLQL ISCTIGLCFI KDLLNNMQTI
VDQFFTDESE TEAIEEKIVV GIFQCLELLY KSPIMNQEHL TIGYDWLQQF CVNKKLKPKA
FAIVHRILFD LRLRTQSGAY FDSVAMRLEL KFGQISAEEL NPPFYLKSIT SGTVEPTFHH
LCTVIRLQLE EIEHLILRSN SLMARLKVLE LEDTDETTQL LKSIERSMCS QLVHILTTLT
HLCNIHLPLG SAMDALLKLL LSMYNCLANL SRHFLACHPI VPVSYEVTKF NLVVKASKPL
ASRIYDLFPF IEENILAQDG VQDDGEEAEG KRPVESSAKA KSNRDKVLRK TKLLPRLVFR
IESYNKIVTQ LSRKTKKDLT YLLHMGTVRD FRIKTSALKE AIEKTVTHRG EDDESNEETD
LEPQLDRDEE GDDDIDASID RTTGSNRSEV IRAVPAGRVS DVSGEALALK NLAKLNERTR
KAAKKRAIAL VDDGEPTDAA PKKMKSMQKK AANIPKINKR VLEERHNQSQ TRHALIDLRR
KAIPVDRQRQ VLYELVEKFE KYPQEKAFAI EEGAIELLRE LQYASDPAIT EHAKLGLALL
GYVPPLPSNG IRILSIDGGG IRGIIVMELL RKLERLTNRR IFDLFDLVCG VSTGAILVCA
LASEKNLTLT EGIHLYKKLA YNIFHRPSTL DKLSGASRLV SSHAYYDIEL WETFLKRHIG
HRRIIDTVML PNVPKFCCVS TTVCDEYIDA HVFRNYTFPR NVQSVYAGCH TARLWEVVRA
SSAAPAYFGD FPLNGQLHQD GGILYNNPTT VAIHEAKCLW PNERIQCVVS FGTGRTRNKS
YDGQKIISKG ILDQASLSSS WKTKFLRILD SATDTEATHT VLSDLLPPGR YFRFNPYLTE
FLSMVEVRPE KISQLEHDTA KYYARNEDKF EQVADLLTQN RSIVRKAYDI RNDLAVLSAQ
YSSNQGLS
//
