ID W5J8P8_ANODA Unreviewed; 452 AA.
AC W5J8P8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Dynein regulatory complex subunit 4 {ECO:0000256|ARBA:ARBA00021301};
DE AltName: Full=Growth arrest-specific protein 8 {ECO:0000256|ARBA:ARBA00031568};
GN ORFNames=AND_009162 {ECO:0000313|EMBL:ETN59250.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN59250.1};
RN [1] {ECO:0000313|EMBL:ETN59250.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN59250.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN59250.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC009162-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the DRC4 family.
CC {ECO:0000256|ARBA:ARBA00009859}.
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DR EMBL; ADMH02002096; ETN59250.1; -; Genomic_DNA.
DR AlphaFoldDB; W5J8P8; -.
DR STRING; 43151.W5J8P8; -.
DR EnsemblMetazoa; ADAC009162-RA; ADAC009162-PA; ADAC009162.
DR VEuPathDB; VectorBase:ADAC009162; -.
DR VEuPathDB; VectorBase:ADAR2_008203; -.
DR eggNOG; ENOG502QQDA; Eukaryota.
DR HOGENOM; CLU_045343_0_0_1; -.
DR OMA; MKHLQYE; -.
DR OrthoDB; 5481777at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039308; GAS8.
DR InterPro; IPR025593; GAS8_dom.
DR PANTHER; PTHR31543; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR31543:SF0; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13851; GAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 215..411
FT /note="Growth arrest-specific protein 8"
FT /evidence="ECO:0000259|Pfam:PF13851"
FT COILED 22..84
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 129..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 270..349
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 452 AA; 53623 MW; 68EE1F8E38051732 CRC64;
MGPKKAKGST VIDGCDMSSM SREQLEQFAL KLRNEMERER EERNFFQLER DKLRTYWEIT
RKQLEEAKAV IRGKERDVEV AQELADQDTK NVMQEMKHLQ YEHQSHIGEL RAEMMTQLKM
AQEDHTLQER ELLNDKRDLK RLLREKEENA ELEIQQLKLK HSELLSVERA KFQEEIEAMT
KLFEQRLASY KEEAEVRHEM ELSEVEERKN GQIAELINTN EQAYREMKSY YNAITQNNLA
LINSMKEEME EMRLQSDKDL KSFTEVMAEN KRLTEPLKSA QAELLELRKK LQYYDRDKAT
LNRVKTRLNS TQKQLSSLKL EQDVLQMRCE KLVEERDQLK RLFEKSMLEL QQKSGLKNSL
LERKLEYIEK QTEQREAILG EVLSLAGIEP QSLSVRIEKL LVQKNDKIQA LRYDLARVSK
MYDDLLSLIE GKLVKYGITL KDLELTNLRQ EK
//
