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Database: UniProt
Entry: W5J915_ANODA
LinkDB: W5J915_ANODA
Original site: W5J915_ANODA 
ID   W5J915_ANODA            Unreviewed;       722 AA.
AC   W5J915;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide-gated potassium channel {ECO:0000313|EMBL:ETN60932.1};
GN   ORFNames=AND_007429 {ECO:0000313|EMBL:ETN60932.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN60932.1};
RN   [1] {ECO:0000313|EMBL:ETN60932.1, ECO:0000313|Proteomes:UP000000673}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT   the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
RN   [2] {ECO:0000313|EMBL:ETN60932.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ETN60932.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23761445;
RA   Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA   Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA   Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA   Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA   de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA   Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA   Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA   Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA   Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA   de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA   Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA   Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA   Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA   Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA   Camargo E.P., de Vasconcelos A.T.;
RT   "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL   Nucleic Acids Res. 41:7387-7400(2013).
RN   [4] {ECO:0000313|EnsemblMetazoa:ADAC007429-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC       {ECO:0000256|ARBA:ARBA00006305}.
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DR   EMBL; ADMH02001843; ETN60932.1; -; Genomic_DNA.
DR   AlphaFoldDB; W5J915; -.
DR   STRING; 43151.W5J915; -.
DR   EnsemblMetazoa; ADAC007429-RA; ADAC007429-PA; ADAC007429.
DR   VEuPathDB; VectorBase:ADAC007429; -.
DR   VEuPathDB; VectorBase:ADAR2_009040; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   HOGENOM; CLU_005746_15_2_1; -.
DR   OMA; SSIPMDC; -.
DR   OrthoDB; 74296at2759; -.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR   PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000313|EMBL:ETN60932.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        185..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        341..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          518..634
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
SQ   SEQUENCE   722 AA;  82146 MW;  4E0AB264ACC614B2 CRC64;
     MQQHDQQQQQ QPSAIALERR SLSLRRHAPP MSAGPCASPP LGATSRLFSA ASSDSIRFHS
     NLSNQNDTDL RVSIDNTCTD SLVTALDDEA LLITDYMNDM AKSKVHFDDV SLYGTPKEEP
     LPNIPPSIEK PSSNFLKNQL QAWFQPTDNR LAMKLFGSKK ALVKERIRQK TAGHWVIHPC
     SSFRFYWDLC MLLLLVANLI ILPVAISFFN DDLSTRWIAF NCLSDTIFLV DIVVNFRTGI
     MQQDNAEQVI LDPKLIAKHY LKTWFFLDLI SSIPLDYIFL IFNQDFSDSF QLLHAGRALR
     ILRLAKLLSL VRLLRLSRLV RYVSQWEEVY FLNMASVFMR IFNLICMMLL IGHWSGCLQF
     LVPMLQGFPS NSWVAINELQ ESYWLEQYSW ALFKAMSHML CIGYGRFPPQ SLTDMWLTML
     SMISGATCYA LFLGHATNLI QSLDSSRRQY REKVKQVEEY MAYRKLPRDM RQRITEYFEH
     RYQGKFFDEE CILGELSEKL REDVINYNCR SLVASVPFFA NADSNFVSDV VTKLRYEVFQ
     PGDIIIKEGT IGSKMYFIQE GIVDIVMANG EVATSLSDGS YFGEICLLTN ARRVASVRAE
     TYCNLFSLSV DHFNAVLDQY PLMRKTMETV AAERLNKIGK NPNIMAQKEE SESGNTETNQ
     ISAVVNALSA EADNVDNLSD GNGSMKKGTS QSSLNELGQT LKMSLPRPKS GEFRALFEGC
     SP
//
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