ID W5JDD6_ANODA Unreviewed; 1180 AA.
AC W5JDD6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=AND_005945 {ECO:0000313|EMBL:ETN62362.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN62362.1};
RN [1] {ECO:0000313|EMBL:ETN62362.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN62362.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN62362.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC005945-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; ADMH02001488; ETN62362.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JDD6; -.
DR STRING; 43151.W5JDD6; -.
DR EnsemblMetazoa; ADAC005945-RA; ADAC005945-PA; ADAC005945.
DR VEuPathDB; VectorBase:ADAC005945; -.
DR VEuPathDB; VectorBase:ADAR2_002161; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_0_0_1; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03286; ABC_MSH6_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 1031..1047
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 131309 MW; 430669BFF06647D5 CRC64;
MSKNKSKLPA SPNTLLSYFA RSPAGNKSAK PSTPTSALAG APRSTKLAES EPAGSTPKSK
KFTIKNEKES AKKETNKKDE HTNGEANEEE EEIGIRKKRR RVITFGDSDS DSGEPQTKTP
EPAHNNNNNN TEGKDKKPFG LSSFEWPIKE DNAESAKKKA EEETAGGPAT KKVKLEAGKR
IEEEDGPEEL ATALDEPVVW AHQKLEFLKP NKIKDIQGNR PGSEKYDGRT LFVPESFLNT
LTPAMRQWWE IKSQHYDCVL FFKVGKFYEL YHMDAEVGVS ELGFSFMKGE FAHSGFPETA
YDRMSTSLIE KGYKVARIEQ TETPEMMQER CKVQRTNSKY DKVVRREVCQ VTVKGTEVFG
QQVRITTNHA PRYMMTIVES SPAGLGAGCR YGVCFIDTSI GLFHLGEFDD DNQQSRLLTL
LSHYSPVIIL TERSATAYSE GTQRIFKTLL AHVPREALTN ESQLWSGEKT LRYLAEKFYG
GSSGGESSKW PPVLRSLVDD SDSLGLTPKQ SSLLALKALG GCIWYLQRSL LDQQVIPLAT
FEQYIPLDAK DDQTAGETSA RIGAANANRY MVLDSITLNN LKIIGGEGSL ADRMDHCCTK
FGKRLFHHWV CVPSCELEVI VQRQQAVTEL IDHVTLLQDV RALLGQLPDM ERLVTQIHAF
GNATCSGRNH PAGRAILYEE LTYGKKKLSD FIATLNGFRA LIALPDMFDN AKSELLVRIT
QSASVGGAFP IETMRKQLAF FDKAFDHEKA LKSGVIAPER GVDSEYDTVE REIETLKTEL
EEYLAEQSKF FGCTVVYFGN DKKRYQLEVP EARAKKATSE YSLESQRAGK NGVKRFHTEE
TRQFLRQMTQ LEDKRKMVLK DLARRIFEKF SLEYSTWKGC VEMVATLDVL TSLAEYARSE
GVCCVPELLA NGSNGKPLIE IEEGIHPCIA SELMESFIPN GISIGGEGKA SLVLLTGPNM
GGKSTLMRQV GLLAVMAQIG SRIPAERCRM TLVDRIFTRL GASDDIMAGH STFLVELNET
SAILKHATSD SLVLLDELGR GTATYDGTAV AGAVVHFLAD RQCRTLFSTH YHNLVDSFHA
DPRIALGHMA CMVENEEGDD PTQETVTFLY KYADGPCPKS YGFNAAKLAG MPMAIIKRAY
ELSKKVERDA LKRKIMMKLV KGAPEPEIRD LVAKLQSCRF
//
