ID W5JFD8_ANODA Unreviewed; 1051 AA.
AC W5JFD8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Brat protein {ECO:0000313|EMBL:ETN63087.1};
GN ORFNames=AND_005204 {ECO:0000313|EMBL:ETN63087.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN63087.1};
RN [1] {ECO:0000313|EMBL:ETN63087.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN63087.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN63087.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC005204-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02001300; ETN63087.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JFD8; -.
DR STRING; 43151.W5JFD8; -.
DR EnsemblMetazoa; ADAC005204-RA; ADAC005204-PA; ADAC005204.
DR VEuPathDB; VectorBase:ADAC005204; -.
DR VEuPathDB; VectorBase:ADAR2_009674; -.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_007697_0_0_1; -.
DR OMA; CCTLVCK; -.
DR OrthoDB; 5387006at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19813; Bbox1_BRAT-like; 1.
DR CDD; cd19798; Bbox2_BRAT-like; 1.
DR CDD; cd14959; NHL_brat_like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24104:SF41; BRAIN TUMOR PROTEIN; 1.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR Pfam; PF01436; NHL; 3.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS51125; NHL; 5.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 309..342
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 781..824
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 828..873
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 874..915
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 916..958
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 959..1002
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 360..401
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 110195 MW; AD9E3D06B7E9CE22 CRC64;
MASSPTPSLD SLPGASNSIG SFGEPADYLS DSPLTTLSGG SGTTTSGSSP PASDSAICDD
FATSSSLESA QSNNGSSESL FPRCTGCKSK QSDAVAKCID CVNFLCANCV TAHQFMHCFD
GHSVYRIAGT GAGTIGSIAP PTTSVTTMTP TLGLLGGGTV GVGTPGTGGG GLDTSLLVSN
ILNGANGGGL GGSKGGFEAA HPRLSSLNVT IKDDASSLVK SMMNNVITPP TSNGTGGVGA
PGNIGCNGTG GGGGGSSNGS SNLLNQFSAT NGSASSDLLT SNGFGNGGGV LSGGGLGGLL
GNGIGGANKP NYFCKRHASE LLKFFCRTCS IPVCKDCMML EHPSGVHECE HNSDTTPKQI
ESLLHTVSEV RNKAQELRSL IKNVEHNSQR IQVQYHKAQN EINDTHQFYR SMVDERKAEL
LKELENFYNA KTVSQSVLLN RSQDQVDKVL QSCEFVERLT KCAGPSETVM LRKFMENKML
LFPTITHDLQ ASYELEFMSN YQAIQIGVRN TYGYIRSNSD LTSAATKQPP IARPTSSNNG
SANNSNNNNG GPMMLTNGGR STSPSNSSTG SLNLLHSSNG SLLLNGGGSA GSHLLDHHQQ
QQQQQHQQHQ HQQHQQHQQR GFGGGVVNGH GNGLSTSPLS GAGGALCNGL SGGGGSFDTN
LISKRFNSAN SLGPFVGEPM VQSLGGGVGG NPYEKWSNGG TGGSADLFSN LADPYTIPLN
PIGGGGGGGG GGGGGGGGGA GGQQDSSVST AAAMIDLSAK LMSTSMFPPK SQIKRQKMIY
HCKFGEFGVM EGQFTEPSGV AVNAQNDIIV ADTNNHRIQI FDKEGRFKFQ FGECGKRDGQ
LLYPNRVAVV RTSGDIIVTE RSPTHQIQIY NQYGQFVRKF GANILQHPRG VTVDSKGRIV
VVECKVMRVI IFDQSGNVLQ KFGCSKHLEF PNGVVVNDKQ EIFISDNRAH CVKVFNYEGQ
FLRQIGGEGV TNYPIGVGIN AAGEILIADN HNNFNLTIFT QDGQLVSALE SKVKHAQCFD
VALMDDGSVV LASKDYRLYI YRYVQVPPIG L
//
