ID W5JFE7_ANODA Unreviewed; 2290 AA.
AC W5JFE7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN ORFNames=AND_005483 {ECO:0000313|EMBL:ETN62801.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN62801.1};
RN [1] {ECO:0000313|EMBL:ETN62801.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN62801.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN62801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC005483-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADMH02001370; ETN62801.1; -; Genomic_DNA.
DR STRING; 43151.W5JFE7; -.
DR EnsemblMetazoa; ADAC005483-RA; ADAC005483-PA; ADAC005483.
DR VEuPathDB; VectorBase:ADAC005483; -.
DR VEuPathDB; VectorBase:ADAR2_008550; -.
DR eggNOG; KOG1811; Eukaryota.
DR HOGENOM; CLU_230725_0_0_1; -.
DR OMA; VHDNCES; -.
DR OrthoDB; 2945465at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1447..1507
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 508..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2290 AA; 256148 MW; 921C6EBF5E185E1A CRC64;
MENFNEYWEL LADKRDSIAK EIIAYYKTLD DREDGTELSE ACRAFLQKNL LINPYPTCQL
LKLLAASRIP GKNASIYEIA TAAVLESFSE DLAATKRYSI LANGLVSMKA LTGLKMRITD
ALDKQQIDLQ LLVLAVFARR SFKLLLHLLP ELSGMLKQQH TADAIEGKQH FLHRLLVDGA
GLSLHQHKSY FHFVRQVVEA NRITGGSFGL SDESFEPVVK AADIGRMYLL AYQVELKRCA
MLKRALVIDE ERLPVAEYAH HTSVLALLVK GQANVLDYDF TVLIDVILKN QIMLEEIETS
QTHQARENVE SMNALHLQTI IVLYKAIETS QSEANGSEQQ QNSSSIIEAQ LKSLLKEADL
PTFLDIVESI LTLLFVRSDT MVSSNGSGDR KHFLCSFALL NVIASSVKTI MITRKHSEAS
DKLCHRFQKL FELVNDMCWR LSLFVDTTAV PVRKQHQANA LIQLTVPPPI PTAMTHTTHA
MSESGTLGSG RGGEVLYRSV ESMTISADGA PTGGVYKRTH YGTLPRHKPS RKQYNRTAAP
PNQSGPSGGS NKELLPQRSH SIGSKGDEPV HRFVRPTAVD EPIAKDERRA FTKLFATPET
LALACLTSDK VAFAKQIIEN YGLQERPVGC LVQRMEQMET LSSKLIDLVQ RQERRSQPDS
PPNSSDSDTL LHDIRTKTAV GFEVSKVLST IETFLKAQTE GTGRELHDND DGIGAVLVAP
MDRFVGRYPF LGMHTGKNLH LSQIVDIVLT LPFKYELNLS VYNFLLKNVQ RNTLRGMSAS
TINEGNGAGR GGIGSGAGPS VEPLMVGNFV SFFGTLIDTM HIAIKTDSQL TDHRTIGQLL
TRELCPLDAV ENGLTLKRRA RFHTMATTVQ VQHMDRSPQL ALDGSISHDR TSQFLQHLQQ
LLQLTTASGA THGSDSLLRI DVRNILLEAL LDGTTSITAL ATMTAKLGIN MVQTIGRWLL
SALSESAKEV IGDGKQHTLW QFLGEQSELL RRICSAQVLT DQSDNSSTSP LVQYKRLQER
TGDREALPIH CDQLCSSHRQ ADPLFPLVSS DRPFCCLLLT RENDTDDDVT PESSRPKHLP
VQNRRLANCS VDDQAIALLE QVEQFAKASE WISASEHLLT AIKRPACEVQ LQERANELRM
YVRVGALLRL EPPEDWRNVR KHSLENSSHV LQQLIEQREY AVCADWIKRH PIDPDRDLEM
FMYAVRKAHG GGGGGDGEQD TEPSLLLFAI IETMPIGAVV KLYEAMLVTI RSVPIVHYML
RYLQNHGARQ PLYQKYRLSL TIFEHLSRTE YEGLWNLVSR PLLILEQCLM NSRLELLAGV
IRSIRPLLAR DLCRQCFEHR EYIRDLQETV HGQGQLSSAK VRNPHHEGLY IGHECVDCLL
RIYASKALEY KVFPTELDPL YHHRRDPTLG EVGSTMSLDS LAGELPVTGV PFVLPKEIPA
RDQWVKDEET LHCMCCRRTF SMLNRRHHCR RCGRVVCHSC SKRKQRLGSF YEEIPVRVCD
DCGRLLGDGG SDFTATNPNT NLQSKRTAEE RSTDRVGMGA NGRSVPQYEW QLTGNERYDR
VIRDEYSYEY APSTGQCLAI CDLHTPNEEI ASFLLYHCAK LEGLLRPLAP GVPNPEIDYA
LVARMLLNLT LGVKVRHGAE GSGASEVEKM KEHAEIILSI VHDNCESLLL DTQQSAAISS
SHHPGSLRKL CDALVKAEKW TLALELSLKC GFSVSGVLAA WGMTCLRAGC YETAREKFSH
CLPRIATEQE CDAVLRMIET PITTVTTFTF TSRRDTIGTN DRVPLVKRPT RSPPLLGEIL
YVLKCTARVI DPLEQAAISG GRILLGTTIG GTQEPATNIQ HTLANLKRIC QGEFGEALAK
TDRRSLGTGL EGSPSTPTTT VSLMCSRLFE ESMHYLLAYG SHQSIVTFLM KHRQTELVAL
RYILVQRVES EVFLQAVLLP CLQRGKLELL VQQLTDLDET LLEWRDHLRY ACRYLETNEM
LNSLYSLQLL LKDPIRASMT CVRFYTQGCR TFSDLHAAEH HLKTSATHLQ NELELCNWQE
VRLNSAGSTV ETHPSLLMKL DPKELNNHIN TILLQLEVTK FLAKCEAKGR QTTALLPKII
KDTSQLPTLF GSVHERLQLA ILTLVCGQNV EEAFGLSYRI IQDYSLDLQR VYALTAKYFI
NHGKIEDVNK LLDAILSNGN GNEPTAEQTL LTTVCDDIVR VSVETAIARH GPAANVKVAL
EALINRTSSV AVRIHCYITT GQLKTAYLLA NRHQRTGDIR KILRQAQLLG QMHVKRLCEA
RLNHQDGEGS
//
