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Database: UniProt
Entry: W5JFV2_ANODA
LinkDB: W5JFV2_ANODA
Original site: W5JFV2_ANODA 
ID   W5JFV2_ANODA            Unreviewed;      2191 AA.
AC   W5JFV2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   30-AUG-2017, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETN61699.1, ECO:0000313|EnsemblMetazoa:ADAC006618-PA};
GN   ORFNames=AND_006618 {ECO:0000313|EMBL:ETN61699.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN61699.1, ECO:0000313|Proteomes:UP000000673};
RN   [1] {ECO:0000313|EMBL:ETN61699.1, ECO:0000313|EnsemblMetazoa:ADAC006618-PA, ECO:0000313|Proteomes:UP000000673}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-
RT   loops in the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
RN   [2] {ECO:0000313|EMBL:ETN61699.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ETN61699.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23761445;
RA   Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I.,
RA   Loreto E.L., Zaha A., Teixeira S.M., Wespiser A.R.,
RA   Almeida E Silva A., Schlindwein A.D., Pacheco A.C., Silva A.L.,
RA   Graveley B.R., Walenz B.P., Lima Bde A., Ribeiro C.A.,
RA   Nunes-Silva C.G., de Carvalho C.R., Soares C.M., de Menezes C.B.,
RA   Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M., Golenbock D.,
RA   Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA   Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M.,
RA   Guimaraes G.M., Goldman G.H., Padilha I.Q., Batista Jda S.,
RA   Ferro J.A., Ribeiro J.M., Fietto J.L., Dabbas K.M., Cerdeira L.,
RA   Agnez-Lima L.F., Brocchi M., de Carvalho M.O., Teixeira Mde M.,
RA   Diniz Maia Mde M., Goldman M.H., Cruz Schneider M.P., Felipe M.S.,
RA   Hungria M., Nicolas M.F., Pereira M., Montes M.A., Cantao M.E.,
RA   Vincentz M., Rafael M.S., Silverman N., Stoco P.H., Souza R.C.,
RA   Vicentini R., Gazzinelli R.T., Neves Rde O., Silva R.,
RA   Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P., Camargo E.P.,
RA   de Vasconcelos A.T.;
RT   "The genome of Anopheles darlingi, the main neotropical malaria
RT   vector.";
RL   Nucleic Acids Res. 41:7387-7400(2013).
RN   [4] {ECO:0000313|EnsemblMetazoa:ADAC006618-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; ADMH02001629; ETN61699.1; -; Genomic_DNA.
DR   EnsemblMetazoa; ADAC006618-RA; ADAC006618-PA; ADAC006618.
DR   VectorBase; ADAC006618-RA; ADAC006618-PA; ADAC006618.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   CDD; cd11823; SH3_Nostrin; 1.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR027267; AH/BAR-dom.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035656; Nostrin_SH3.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF48403; SSF48403; 3.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120};
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077,
KW   ECO:0000256|SAAS:SAAS00803874, ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000673};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS00803871};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM   1388   1409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1884   1904       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1916   1934       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1954   1971       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1983   2004       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2016   2036       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2129   2150       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      561    836       F-BAR. {ECO:0000259|PROSITE:PS51741}.
FT   DOMAIN     1137   1190       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   REPEAT     1275   1307       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN     1275   1307       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   DOMAIN     1423   1501       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      735    762       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2191 AA;  244958 MW;  9911487BDCFE02DE CRC64;
     MMKRNYDVQQ VASTFDGGKH HSGSSTNLFD KITKRYSGVI GARFLRKNPG RKGGVAEPLS
     DSYDMCGNRS DDFRPEIGAP VLISKTMKFD FDTDSSIEQL PLPRPPVTGT GTGTTGIGAR
     GRSVATPSTS GDSDVYVDAN SSLPNFGDIK FTFLPERNNN CSAFRNENVR QEQQQQQQQE
     PNLARMLEKN RSKSAHNLHR GFGDQRLALV KAPSLNLSAP VTTYSSSPGA VSVGQTVVRV
     PNGSVVARCT SASVPNSPAV ESIYDFPRST RSDGIRKPHG ESQYDLTRSH HVLNEINLSL
     VSDDSVEGHN LYQNLPSPDR YDVPSSCLVA GSDLERSFPS ARRSSVASDQ STQEEEFDMK
     SASFQSLADA NGSGGQLVVS MEELNELTRQ INEAISTFGD GDASAFAPIT LPDSDEYCEH
     RQQLHPSERR LTLMKNRAVS GKHLLDFERR KAKITKKWSG FKSWIGEEQG RIREVVNKHA
     ALQRVGSEPV DQSAKAVKRQ NSDLTTTTIS SDQSSGRTGT TDHEQTMATV VSESSGGTEA
     RHERSRSSED RFEGSKTIRR KSANAEILEG QNGFEEVRRY VKQGGDFGKD LVAILHERSE
     LEQLYAKSLS KIANKLNKAC RDLPGTIAES WRAVSTELEG RSEVHRQFSN SLAEEIVKPL
     KAVIDNQHKA RKTIETNVDK SARILAEWRT AEVKAKKNSH GAARENEKLQ DAMLDVKLQR
     TPSIGLLHKA NEKDAKVSEK DSTKLESKRK KAEEAVKKAD VEYYTLCIRA ERARVDWEMS
     VLRGSSMLQT LESQRLNQFK TYVSDYLKLS AEMSPLLTKT IDRLGPQVAL CSVAKDLDVL
     KNIRRATEGP SEQLLPDFYC EHTTLAMNRE RRKQSLVKLL QLIRQDLDRE RRSRNGLKGF
     SQTLDKTGES NQNIADKLYH IRSMLTYLEG ARYKLQSALL ELDHKPRSSH PLAQHIQITR
     DRTGLQTSVL KVPLWLKHEQ DDETGATPSN GTVACDETET PASCLDIKND TLIKHIVHKY
     ARNNGTTNGD SQEHYTISKA GKSALHDENS PAWDRGVADG VSNQPDSDFD EFSSQDEDED
     RCSVAPKQHH EHTNGGGHTT TVVINGGLNG NDHSTDTIAT TNGTSASSTA VVLGRCRALF
     NYTPKLYDEL ELQPGDILEV HIKQEDGWWL GALRGQIGIF PATYVEEIPC CENGNAQVLE
     WCLNSTSKRV TGSMYQENLI SSIDELCSQG YMTMVSQLIQ QMDPAVDMSV CPFFKCMQLL
     LNDGRIDIDK KSGFFEGTAL HYAAKNKLVH AQRVLLAKGA SLGVMDLLQE MPISAMDPIV
     LENHLDSCVF PECWSLSDKT YQFQLDLSNF VKPSKGKSGQ ATCQTFDEML PILRLRELNV
     SDIPLEGVIP YIILVIFVFF VPIVLSNLIN GLAISDIAFN PITNKYPIHL AAETCDVHNL
     QELVKSHLLL IDQKFNGCTA LFMLFEMLTA ESWENVFECI KVLLEQGADI NTTGTDEKSP
     IAILVSGNDS WRKTILEYCL THYYVDVDVR MSTTNSELIR NAIQNHFPDV TIPVTMVESE
     FTISLLETIL INDSEIVFLE ACRLFKANKS SPNSDNNHET PSNVLVIPDE DLENLLFKAV
     LKNRLKAIAL LLEPSWKKGQ LFDADWIVKP LSWVLHTCCD FGNVKVLEWC LNSTSKPVTG
     TMYQDNLLSS IDDELCSQGY STMLSQLIQQ IDPAVDMNVC PFFKCMKLLL RDGRMDIDKK
     SGFLQTTALH CAANYKVVHA QELLLSKGAT LRATNLFNQI LISAIDPNVL EKYLDSCVSS
     RFQSHTDNKY YMQMDLSNIV RQPMQKSKTK SASNNLPQTP SQKAESYDEL LLILNLAQSS
     DKKHLLQHPL IYIILMQKWL RLRIFYYTNL SLCAAFSLLF ILYATMFYGC DNTPNFWYSA
     TYASLIILLT FMGMRELFQC CLNVGEYIRS VENYVEISLI VGATYVLYLD YQNEKETEVP
     ALIVILPALN LTLLVGSLPM LSLSTHMVML KTVSKNFLQC FLLYAIILVT FAASFYTLTR
     GSNARSNITQ SNELLRTFTE MPDLDDGENL TQTLISFKKS IDMLNKKIQS NNDEEASFDK
     FENFPLSVVK IIAMQIGEMN ISDIPLDGAI PYIILLIFMF FVPIVLSNLI NGLAISDIAA
     IKDESEIIGL VQRVSVIHKF ETALEKIARY M
//
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