ID W5JHK7_ANODA Unreviewed; 1880 AA.
AC W5JHK7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Ankyrin {ECO:0000313|EMBL:ETN63852.1};
GN ORFNames=AND_004422 {ECO:0000313|EMBL:ETN63852.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN63852.1};
RN [1] {ECO:0000313|EMBL:ETN63852.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN63852.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN63852.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC004422-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; ADMH02001167; ETN63852.1; -; Genomic_DNA.
DR STRING; 43151.W5JHK7; -.
DR EnsemblMetazoa; ADAC004422-RA; ADAC004422-PA; ADAC004422.
DR VEuPathDB; VectorBase:ADAC004422; -.
DR VEuPathDB; VectorBase:ADAR2_005850; -.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_000134_7_0_1; -.
DR OMA; ISVNHAQ; -.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0009605; P:response to external stimulus; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT REPEAT 22..54
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 55..87
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 88..120
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 121..153
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 154..186
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 187..219
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 409..566
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 889..971
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1015..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1677..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1732..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1880 AA; 209559 MW; BB97B4FDFD4E0F1B CRC64;
MFPKVAGVLL DNGAQIDATT KKGFTPLHLT AKYGHMKVAE LLLEKNAPVD AQGKNGVTPL
HVASHYDHQN VAMLLLEKGA SPHATAKNGH TPLHIAARKN QLDIAKTLLK YEAQPSAESK
AGFTPLHLSA QEGHTEMAGL LLEARANPDH QARNGLTPMH LCAQEDRVSV AQVLVKHGAN
LQAATKAGYM PLHVASHFGQ ANMVRYLLEQ QADVNASTGI GYTALHQASQ QGHCHIVNIL
LENNADPNAI TNNGQTSLKI AQKLGYISVL DSLKSVTDSR ATPDQPPSEE KYRVVAPEAM
HETFMSDSEE EGGEDTVLSD QPYRYLTVDE MKSLGDDSLP IDVTRDERID SNKMVQSTDS
HQFPPTALED SISPQHASMV QSGISAADFT DNINIERQMH VGKLHWRNFL VSFLVDARGG
AMRGCRHSGV RIIVPARSAA QPTRITCRYV KPQRTMHPPP LMEGEALASR VLELGPVGAK
FLGPVIMEVP HFASLRGKER EIVILRSDNG ETWREHNIDM SEEIIHDVLN ECFEPEDLAQ
LDELGGGRIC RFVTYDFPQY FAVISRIRQE VHAIGPEGGM VSSTVVPQVQ AVFPQGALTK
KIKVGLQVNL FKPRKGVAPE KLRKISVNHA QPIDPDLTAK LLGRGVAVSP VVTVEPRRRG
TTRAQWEDVT GSTPLTFVND CVSFTTTVSA RFWLMDCRNI ADATKMATEL YKEAIHVPFM
AKFVVFAKRT DTLEARLRVF CMTDDREDKT LEHQEHFTEV AKSRDVEVLE DKPQYIELAG
NLVPVTKSGE QLSLPFKAFR ENRLPFAVRV KDQHADIVGR TLFMREPKIA KGEPPQQPIC
ILNIVLPETI IPEQTTTTIR DSHEIMLRVG RSRAVAPPRQ LVDDQNYLGE LRIVDISNLL
GEDWIKLAPE IGVSETDVEN IVAQIPTSTA QQAQAMLKQF QSKPNNDFNI LENGLRTIHR
DDIVEQCIRS ATTTGTTTTV TMRNKASFSI GKRNVDAVDL LTETDSIAKM AQKDDRLSKK
ESTKYSVEEK SVVEESEESE EELVKKTVAE RRKQIEKRLS ADRSIPASAQ KKEIVEEIIS
IKRQSVIDDT RARHEEEILM QKPIDNTYKS TTMPEPVVKL KTAVVKDGPT VRKDEFDQEL
QDRFKSTLKN VEEFEHKSQV LEHTMVSDVT QQIHSTAPRV VEELKKPTEE QPLPELVELR
QKIVPSFEEL PCPPVARERA PIPAKRTSLT KEEPEEFTSV IEESIKDVKQ RISSFETKTK
TETLHDSKQS SKETGGAHES WIEEHRKELK QAVEERAATM REHFDDDVIA SEQTFSQAHT
VEETSKVTSS QQHETTVKEQ IKLQTVSFAH EKDSFSDEPT SEGFVAHADG TKWQDQDSEP
SSLSEGLRQV HQVRTTEESF SQQFKSETVS KVEETVTKMG ATVDTTSTIA ALATLLHGTE
APLNLDKDDR AVVREEFVAR SAESSSVIDR KIESIVREQH DAEPVVERHD VQRDVREISD
KMAGAMMKET LLLDDGTIPV LSSTEAYTVE SFDGLTSETM HKDASGMVAE LRGKTFSSIE
TGVCEGEEEV SEKIVEKEEK MRRKEEKVVT QTPDVPAITE TVSRTISQEI TSKIPVASKK
GSPESKEPPT KPEKTETKEQ HKPSVEPSAA LKCESISFEE RDQGVTELVD SSVSKIPRFD
SSKPAAKLPD VAPIKSPEPD SNNLSKIPIL KDRKVSEQFS SDSCETVIMQ KSHIEQSDQP
LLHKADSDER SSERADVAAL AVATVSTQEE DEEVMQATIA SERGHDLTEI ITTDNRAVTP
DDFIDEIIEE AHDKVQQLQS AEATLGTTLD LSHSEEEQFD KSGYRMPEYV SDARSTGRYY
ETEPFDDEGD QEDQEKWKGR
//