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Database: UniProt
Entry: W5JJ82_ANODA
LinkDB: W5JJ82_ANODA
Original site: W5JJ82_ANODA 
ID   W5JJ82_ANODA            Unreviewed;      2347 AA.
AC   W5JJ82;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   05-JUL-2017, entry version 30.
DE   SubName: Full=Voltage-gated ion channel {ECO:0000313|EMBL:ETN64412.1};
GN   ORFNames=AND_003816 {ECO:0000313|EMBL:ETN64412.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64412.1, ECO:0000313|Proteomes:UP000000673};
RN   [1] {ECO:0000313|EMBL:ETN64412.1, ECO:0000313|EnsemblMetazoa:ADAC003816-PA, ECO:0000313|Proteomes:UP000000673}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-
RT   loops in the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
RN   [2] {ECO:0000313|EMBL:ETN64412.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ETN64412.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23761445;
RA   Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I.,
RA   Loreto E.L., Zaha A., Teixeira S.M., Wespiser A.R.,
RA   Almeida E Silva A., Schlindwein A.D., Pacheco A.C., Silva A.L.,
RA   Graveley B.R., Walenz B.P., Lima Bde A., Ribeiro C.A.,
RA   Nunes-Silva C.G., de Carvalho C.R., Soares C.M., de Menezes C.B.,
RA   Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M., Golenbock D.,
RA   Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA   Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M.,
RA   Guimaraes G.M., Goldman G.H., Padilha I.Q., Batista Jda S.,
RA   Ferro J.A., Ribeiro J.M., Fietto J.L., Dabbas K.M., Cerdeira L.,
RA   Agnez-Lima L.F., Brocchi M., de Carvalho M.O., Teixeira Mde M.,
RA   Diniz Maia Mde M., Goldman M.H., Cruz Schneider M.P., Felipe M.S.,
RA   Hungria M., Nicolas M.F., Pereira M., Montes M.A., Cantao M.E.,
RA   Vincentz M., Rafael M.S., Silverman N., Stoco P.H., Souza R.C.,
RA   Vicentini R., Gazzinelli R.T., Neves Rde O., Silva R.,
RA   Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P., Camargo E.P.,
RA   de Vasconcelos A.T.;
RT   "The genome of Anopheles darlingi, the main neotropical malaria
RT   vector.";
RL   Nucleic Acids Res. 41:7387-7400(2013).
RN   [4] {ECO:0000313|EnsemblMetazoa:ADAC003816-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; ADMH02001019; ETN64412.1; -; Genomic_DNA.
DR   STRING; 43151.ADAR004112-PA; -.
DR   EnsemblMetazoa; ADAC003816-RA; ADAC003816-PA; ADAC003816.
DR   VectorBase; ADAC003816-RA; ADAC003816-PA; ADAC003816.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10037:SF252; PTHR10037:SF252; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000673};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   TRANSMEM    601    623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    719    742       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    808    828       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    840    863       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    875    899       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    931    954       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    998   1021       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1356   1375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1387   1405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1448   1467       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1564   1587       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1640   1659       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1671   1693       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1728   1745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1766   1787       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1853   1875       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      235    263       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      291    318       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      319    346       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      347    374       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   COILED     2028   2056       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2347 AA;  268420 MW;  FAEFBC0AAC9CC854 CRC64;
     MHDGFVIRDK LRELFDLEIG QTEMLTTICK SCLKKVCTAR NIRDWFNKQN LKYQQLMCSG
     SDPQAGTNAS NSPSMIVKEH SPLVKSTTHE EASVSGDTDA IEEDVQYFTV STEDETIRCS
     EEALVDAQDD ASVDPKLQQS AEFQVQLIGD ISLNEQSSYK IVQLGEKPTI VTKDTKNNRC
     YISIDGNTFL GMDTDTESVN EEILSVQSEQ ELDEEESATS VQQNGCETAE VRDDLECSLC
     GMQFDLEAQL IDHGVETHGD RFELLQCKGC YIQFASKRSL RRHRCDAEGK FQCRYCEKVL
     KTRNAWKSHQ NMHTGEKSFH CDLCDRKFSQ YSSMRRHRLV HTDEKPYECE YCYKKFRQTC
     ILQAHRRRHT GEKPYKCDVC GNSFRENSAT TITTTTNTAT AAATAPTTGG TKKNASKKKK
     KSSNMLGRKQ SIKGEPVLAD YGPEESLNES ADIEWVNKLW VRRLMRLCAL ISLTSVSLNT
     PKTFERYPFL QYCTFCCDSV ATLLFTSEMI AKIHIRGALR GEAPYFKDHW CQFDASMVLF
     LWLSVILHVF EMLGDADNVA YLSTVRAPRP LIMIRFLRVF LKFSMPKSRI NQIFKRSSQQ
     IYNVTLFFLF FMSLYGLLGV QFFGELKNHC VLNTTEPATL TINSLAIPDT FCSLDRNSGY
     QCPTGMKCMK MDFLTNYAMG FTGFEDIATS IFTVYQAASQ EGWVFIMYRA IDSLPAWRAA
     FYFSTMIFFL AWLVKNVFIA VITETFNEIR VQFQQMWGVR GHIQNSTASQ IITGDDSGWK
     LVTIDDNKHG GIAPETCHTI LRSPYFRMLV MTVVLANGIV TATMHFKHDG RQRRVFYEKY
     YYIEIAFTFF LDLETLFKIY CLGWRSYFKH SIHKFELLLA IGTTLHIIPA LYLSGFTYFQ
     VLRVVRLIKA SPMLEGFVYK IFGPGKKLGS LIIFTMCLLI ISSSISMQLF CFLCDYTKFE
     SFPDAFMSMF QILTQEAWVE VMDETMIRTS KTLTPLVAVY FILYHLFVTL IVLSLFVAVI
     LDNLELDEDI KKLKQLKFRE QSAEIKETLP FRLRIFEKFP DSPQMAILHK IPNDFTLPKV
     RESFMKQFVL EMEPEDLEGY QRPMPECWDS RIAYKKHRPI NVINKTTKVC MVGSDLRKLA
     ITHIINDSNN QRLMLGDSSM LPVAGTKAGL KPQGTITQTK PWRVDQKKFG SRSIRRSVRS
     GSIKLKQTYE HLMENGDIGA ASRVTSSRAR PHDLDIKILQ AKRQQAEMRR NQREEDLREN
     HPFFDTPLFA VPRESRFRKI CQRIVHGRYD ARLKDPLTGK ERKVQYKSLH NFLGLVTYLD
     WVMICVTTLS CISMMFETPQ YRVMEHVSLQ VAEYAFVVFM SLELALKILA DGLFFTPKAY
     IKDVASVLDV FIYVVSTSFL IWMPRQVPSN SSAQLLMILR CLRPLRIFTL VPHMRKVVYE
     LCRGFKEILL VSTLLILLMF IFASYGVQLY GGRLARCNDP TIQKREDCVG VFMRRVFVTK
     MKLTPGVNES YPSMLVPRVW ANPRRFNFDN IGDAMLALFE VLSYKGWIDV RDVLIKALGP
     VHAIYIHVYI FLGCMIGLTL FVGVVIANYS ENKGTALLTV DQRRWCDLKK RLKIAQPLHL
     PPRPDGRKFR AFVYDITQHI AFKRCIAVVV LVNSMLLSIT WTKDEVHTER LVIVSTILTF
     VFVIEVVMKN IAFTPRGYWQ SRRNRYDLLV TVAGVVWIFL QTTLRSDLSY FIGFMVVILR
     FFTITGKHTT LKMLMLTVGV SVCKSFFIIF GMFLLVFFYA LAGTILFGTV KYGEGIGRRA
     NFGSPVTGVA MLFRIVTGED WNKIMHDCMV QPPYCTPAAN YWETDCGNFT ASLIYFCTFY
     VIITYIVLNL LVAIIMENFS LFYSNEEDAL LSYADIRNFQ NTWNIVDIHQ RGVIPVRRVK
     FILRLLKGRL ECDPQKDRLL FKYMCYELDK LHNGEDVTFH DVINMLSYRS VDIRKALQLE
     ELLAREEFEY IIEEEVAKQT IRTWLEGCLK KIRANNVAKQ QNSLIAGLRA TNDQKLQQQQ
     QQQQQQQQQQ QQQQQQPQQP PATISNPQHQ QQQQLQQPPP LAQQSSIQTQ TLSSQASSPL
     SPATQSLQQT ALTSPSQLSK QSDELGKDDS SDPASGIAPL ATASTGLVGP SSTLPPTIDQ
     TVKDAENNAK NRKKIQTQTV LNRSDSTGSS SGRKFLAPTL SDPMQAKNEK DRYLSKKKQH
     QQQQQQMQSR GPSSASMTGS GGAGKGAHLT ELSSHSLHLH YHHSFGHGYG GGDHSPHSHH
     HHHHHHGTGQ GQSQQQQQQP QQPSSAQQQA GSAGSKFGSH SHTNMIYEVH DWWQEQVLST
     HSEEEDN
//
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