GenomeNet

Database: UniProt
Entry: W5JM02_ANODA
LinkDB: W5JM02_ANODA
Original site: W5JM02_ANODA 
ID   W5JM02_ANODA            Unreviewed;       672 AA.
AC   W5JM02;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=AND_004359 {ECO:0000313|EMBL:ETN63910.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN63910.1, ECO:0000313|Proteomes:UP000000673};
RN   [1] {ECO:0000313|EMBL:ETN63910.1, ECO:0000313|EnsemblMetazoa:ADAC004359-PA, ECO:0000313|Proteomes:UP000000673}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-
RT   loops in the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
RN   [2] {ECO:0000313|EMBL:ETN63910.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ETN63910.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23761445;
RA   Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I.,
RA   Loreto E.L., Zaha A., Teixeira S.M., Wespiser A.R.,
RA   Almeida E Silva A., Schlindwein A.D., Pacheco A.C., Silva A.L.,
RA   Graveley B.R., Walenz B.P., Lima Bde A., Ribeiro C.A.,
RA   Nunes-Silva C.G., de Carvalho C.R., Soares C.M., de Menezes C.B.,
RA   Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M., Golenbock D.,
RA   Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA   Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M.,
RA   Guimaraes G.M., Goldman G.H., Padilha I.Q., Batista Jda S.,
RA   Ferro J.A., Ribeiro J.M., Fietto J.L., Dabbas K.M., Cerdeira L.,
RA   Agnez-Lima L.F., Brocchi M., de Carvalho M.O., Teixeira Mde M.,
RA   Diniz Maia Mde M., Goldman M.H., Cruz Schneider M.P., Felipe M.S.,
RA   Hungria M., Nicolas M.F., Pereira M., Montes M.A., Cantao M.E.,
RA   Vincentz M., Rafael M.S., Silverman N., Stoco P.H., Souza R.C.,
RA   Vicentini R., Gazzinelli R.T., Neves Rde O., Silva R.,
RA   Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P., Camargo E.P.,
RA   de Vasconcelos A.T.;
RT   "The genome of Anopheles darlingi, the main neotropical malaria
RT   vector.";
RL   Nucleic Acids Res. 41:7387-7400(2013).
RN   [4] {ECO:0000313|EnsemblMetazoa:ADAC004359-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADMH02001150; ETN63910.1; -; Genomic_DNA.
DR   STRING; 43151.ADAR001442-PA; -.
DR   EnsemblMetazoa; ADAC004359-RA; ADAC004359-PA; ADAC004359.
DR   VectorBase; ADAC004359-RA; ADAC004359-PA; ADAC004359.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   OMA; NFMELTE; -.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000673};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    358    376       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    396    415       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    485       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    649    669       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       95    122       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   672 AA;  77548 MW;  3CF03396EA3957BB CRC64;
     MGAMFRSEEM SMVQLLIQPE AAYQSVAELG ELGIAQFRDL NADINMFQRK YTSEIRRCEE
     MERKIGYIRR EINKDSVTIP DMPEVIPRTP NSREIIDLEA QLEKTENEIV ELSENNHALL
     QNFMELTELK NVLEKTQVFF SDRSNVQNLE ATGGEAANDG KPLGFVAGVI SRERIIGFER
     MLWRVSRGNI FLRQAVLEEA LVDPKTGDSI HKIVFVAFFQ GEQLKSRVKK VCTGYHASLY
     PCPNESSERE EMLRGVRTRI EDLKMVLGQT QDQRQRVLLN VAKEVPTWEI IVKKVKAMNI
     FGSSWSINYN TSTVMENKEL QLNPTTDYSE TVYWYGLDPL WMLATNKIIF LNSFKMKLSI
     IFGVVHMIFG VSMSVVNHRH FHRLENVLLE FIPQMLFLVL LFAYMCFMMF FKWIVYSAVT
     DEDHLKPGCA PSVLIMFINM MLFKNQEPLE TCKEYMFDGQ DTLQVIFIVL GLICIPWLLL
     AKPLYIMVQR KKKGTEHVAE SAHQSSSNHH DDEPMSEIFI HQAIHTIEYI LSTISHTASY
     LRLWALSLAH AQLSEVLYNM VFTIGLSNDS YVGAILIWLV FWPWSVLTIG ILVGMEGLSA
     FLHTLRLHWV EFMSKFYDGL GYAFKPFSFK AILEEEECRL LQLASHDTLI ITVVTKTMMT
     MMMMMMMMAT NL
//
DBGET integrated database retrieval system