ID W5JPA3_ANODA Unreviewed; 2296 AA.
AC W5JPA3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Notch {ECO:0000313|EMBL:ETN64594.1};
GN ORFNames=AND_003659 {ECO:0000313|EMBL:ETN64594.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64594.1};
RN [1] {ECO:0000313|EMBL:ETN64594.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN64594.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN64594.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003659-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADMH02000947; ETN64594.1; -; Genomic_DNA.
DR STRING; 43151.W5JPA3; -.
DR EnsemblMetazoa; ADAC003659-RA; ADAC003659-PA; ADAC003659.
DR VEuPathDB; VectorBase:ADAC003659; -.
DR VEuPathDB; VectorBase:ADAR2_008610; -.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_000576_0_1_1; -.
DR OMA; CSMPTES; -.
DR OrthoDB; 5473534at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 22.
DR CDD; cd21706; JMTM_dNotch; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 24.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 12.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00248; ANK; 7.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 24.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 17.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 19.
DR PROSITE; PS50026; EGF_3; 24.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 13..49
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 51..87
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 89..124
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 126..162
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 164..200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 202..238
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 240..276
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 278..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 316..352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 354..392
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 471..507
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 509..545
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 547..583
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 585..621
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 634..668
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 670..706
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 708..744
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 746..782
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 784..822
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 824..860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 862..898
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 901..937
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 988..1027
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1028..1065
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1066..1105
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1469..1501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1502..1527
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1536..1568
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1569..1601
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1602..1634
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1695..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1972..1994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2075..2109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2221..2272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2277..2296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 16
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 30
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 17..28
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 22..37
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 39..48
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 77..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 93..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 114..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 152..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 190..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 228..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 266..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 304..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 342..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 363..380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 382..391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 459..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 497..506
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 535..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 573..582
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 611..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 658..667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 696..705
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 734..743
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 772..781
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 793..810
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 812..821
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 850..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 866..876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 888..897
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 927..936
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2296 AA; 247382 MW; 3971C511EDDBA0E4 CRC64;
MHQRYTGTQC EIDIDECATN PCLNGGICRD MVNSFKCTCA IGFSGLRCQI NIDDCMSQPC
RNGGICHDSI AGYKCECQPG YTGLSCETNI NDCQSNPCHR GACIDGDNSF TCLCNPGYTG
YLCQIQINEC ESNPCLFGGH CEDLVGSYLC RCQPGTSGPN CEVNVNECHS NPCRNGAKCI
DGINRYTCQC VPGYTGFHCE TNVNECASDP CANGGVCMDL VNGFRCECPR GYFDARCLSD
VDECASNPCI NGGRCEDGVN QFICHCPPGY GGRRCEIDID ECGSNPCQHG GICRDGLNAY
ACQCMPGYTG RNCEVNIDDC VANPCRNGGS CIDLVNGYKC VCRGPYTGRD CESRMDPCLP
NRCRNGAKCS PSSNYLDFSC SCTLGYTGRL CDEDINECEL SSPCRHGATC RNTNGSYQCI
CAKGYEGRDC AINTDDCASF PCQNGGTCLD GIGDYTCLCV DGFEGRNCEV DINECLSQPC
QNGATCNQYV NSYTCTCPLG FSGMNCQTND EDCTESSCMN GGTCIDGINA YNCSCETGYT
GSNCQFRINK CDSQPCRNGA TCHDYENDFT CHCSYGYTGK QCLDYVDWCA QAPCENGATC
TQQENTYHCQ CAAGWTGKLC DVEMVSCKDA AARKGVDVRH LCRNGTCEDF GNSHHCRCKP
GYTGSYCRHE INECESQPCR NGGTCKNLIG AYRCNCRAGF QGQNCELNID ECKPNPCRNG
GICHDLVNGY KCSCPPGTIG VLCEINTDDC TPGACHNNGS CIDRVGGFEC RCPPGFVGAR
CEGDINECLS NPCSNPGTLD CVQLVNDYHC NCKPGHMGRH CEVKVDFCAN DPCLNGGQCS
TRQSGHHCLC TDGYYGKNCE YSGHDCDSNP CINGLCQIAD DGGYRCECPL GTSGINCELD
VLDECNSNPC EKGAQCQNRL GDFECFCPAK WKGKTCNEYD PHFNGWFDTT HQRKSGNGGL
GGLGGIGGGP GGLPNMYAID LEYQRAQCVK KGCREKQGNL RCDEECNTYA CDFDGNDCSL
GINPWLNCTA SIKCWEVFLD GFCNEECNNP QCLFDGRDCE KKLQPCNPIY DAYCQKHYAN
GFCDYGCNNA ECNWDGLDCE NEKEPALLAE GAISTILLMD LTAFRAKRVQ FLRDLGHHLR
TTVRIKKNAA GVEMIFPWKG GTALQGLTDS EFGRKHHVVY TETRQTGIQV YLELDNRKCI
GASGAECFGT ANEAAEFLAA TAAKHSLSKQ FPIYQVKGVN PDDELPGTTN VNYVLVGFFG
LLGLACCTVL VVNRKRAHGI TWFPEGFFTA NTNVRRPSRR RPDGQEMRNL NKNPSMVDMV
VNGHGGGAVG SGGSMMGGHS QQWCNSDDES EMPQRKRMRA IDQGYSSDHT AITDYEETEP
RVWAQQHFEA ADIRDHPAMM TPPTHHDGEV RDVDVRGPCG MTPLMVAAVR GGGGLDSGED
IDSTDDSAAQ IISELVAQGA ELNATMDKTG ETSLHLAARY ARADAAKRLL DAGAEANSQD
NTGRTPLHAA VAADAMGVFQ ILLRNRATNL NARMHDGTTP LILAARLAIE GMVEDLITAD
ADINAADNSG KTALHWAAAV NNVDAVNILL THGANRDAQD DKDETPLFLA AREGSFEACR
ALLDNFANRD ITDHMDRLPR DVASERLHHD IVRLLDEHVP RSPQMVTSAI PTSTIMSPTH
AHLITHPTII ASAKQQGKQK KRQKVTGANT NLQPPTGASM VTGTIGGTVN SNSTLVGSSA
NSVASVLGQN PASPENDVTA NSIRRKTTAK KPTVPTSANG GTGGGKKLSS AGSGGGLTEM
GLTEDQLSSV DSPLANLNSP YDSVSLYSNA MTVHQLEATS NAIGSSAAAA GTVVGPGIMP
KKPPSYEDCL KSAHSIQSLH NMQHDGYGYS LGGNTGTGNQ FADLLMSQQQ QQRGGVNAPN
VNATATIGSN LVHTVMHAMG ESGLSPPYSN QSPPHSVQST MALSPQGYIV SPDHYSFAGS
PSPAKTRPSL PTSPTHIQAM RHAQHQKHNN KMISNGNLQQ QQQQQQLAST SLLGSSGGNN
GANLMLNGSS MLGGLQIQNF VTGSSGLELA GFCSPTGQGS QASTSQGVAG NNSGAMSSSN
SPGMATAPTH ALSPLTQQQQ QQVLVMVAQQ QAQLNNQHQQ QQLQQQLQHQ HQQQQHHQHQ
QQQHQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQIGQ QPQQQLGQQQ QQPQQASFYQ
YLTPPSQHSG GDTPNHMVPT LDSYPTPSPE SPGHWSSSSP HSTSDWSEGV QSPANNVYVT
TAGGHQANKG SEAIYI
//
