ID W5JPK0_ANODA Unreviewed; 585 AA.
AC W5JPK0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Coagulation factor XI {ECO:0000313|EMBL:ETN64810.1};
GN ORFNames=AND_003431 {ECO:0000313|EMBL:ETN64810.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64810.1};
RN [1] {ECO:0000313|EMBL:ETN64810.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN64810.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN64810.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003431-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC {ECO:0000256|ARBA:ARBA00024195}.
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DR EMBL; ADMH02000867; ETN64810.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JPK0; -.
DR STRING; 43151.W5JPK0; -.
DR EnsemblMetazoa; ADAC003431-RA; ADAC003431-PA; ADAC003431.
DR VEuPathDB; VectorBase:ADAC003431; -.
DR VEuPathDB; VectorBase:ADAR2_004112; -.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_004497_6_1_1; -.
DR OMA; KKTLCHA; -.
DR OrthoDB; 3448513at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24260; -; 1.
DR PANTHER; PTHR24260:SF154; GH18608P-RELATED; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..585
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010155761"
FT DOMAIN 42..289
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 319..584
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 585 AA; 65546 MW; FC8CF1338C3541C3 CRC64;
MARFWWCYAL VFGSLLLLLS SLFAPGQAQT CGRRMVDLMA LIHKGNAAKA GYWPWHAALF
ENKIRSFEYM CGGSIVSQNL ILTAAHCLLT ERGLIAAERL LVQVGRNRLK LADTRGQEHE
AHQLITHPDF DVNDLVHDIA LIKLATDISF TNYIQPVCLW DRNVDLQNIV GTKGFIVGYG
FDDSDKVSDY LKDAEIPVVD SFTCINSNPE AFGLKLKSKM YCAGARDGVS ACNGDSGGGM
FFTYGNVWYI RGLVSFIPLR DQVALCDPNQ YTVFTDVAKY LDWIREHYRE PSSGSSGGGS
PIESPLDQSS KLRLLNLDVC GKSRYMNRAE SSKPVFLGYP WVALLEYAVD GEREKQTLCH
GTLISDRYVL TAGHCITQLP KRFRLTTVRL GDYDIKTTRD CESVNGEQEC APPVQVMRIE
SAIVHSGFNT PKYANDIALI RLRERAVISQ SNVQPICLPV SNELRSFKPT TYTLTAWPIG
GNVLGRADRQ VVDSVECQAN YTRYSITLEK TFRQICLKQD QSSGTRCTFP KSAAPLQTIQ
QLNGENRYVM HGLLSYGPKD CSQAYPDVYT YIGPYMEWIL TNIHE
//
