ID W5JQL7_ANODA Unreviewed; 610 AA.
AC W5JQL7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Xaa-pro aminopeptidase {ECO:0000313|EMBL:ETN65044.1};
GN ORFNames=AND_003196 {ECO:0000313|EMBL:ETN65044.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN65044.1};
RN [1] {ECO:0000313|EMBL:ETN65044.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN65044.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN65044.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003196-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; ADMH02000792; ETN65044.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JQL7; -.
DR STRING; 43151.W5JQL7; -.
DR EnsemblMetazoa; ADAC003196-RA; ADAC003196-PA; ADAC003196.
DR VEuPathDB; VectorBase:ADAC003196; -.
DR VEuPathDB; VectorBase:ADAR2_010862; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_2_1; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ETN65044.1};
KW Hydrolase {ECO:0000313|EMBL:ETN65044.1};
KW Protease {ECO:0000313|EMBL:ETN65044.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 43..136
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 318..533
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 548..610
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 610 AA; 67230 MW; 5AE443AE642061A7 CRC64;
MKPTGEVLTA LRQLMANLPN NLGAIGAYII PSTDAHQSEY LAARDERRAF VSGFDGSAGT
AVVTESEALL WTDGRYYQQA AKQLDSNWTL MKEGLPSTPS IDAWLAKILQ PGSRVGVDAN
LITTAAWNPL QTSLKTAGCS LLAVEPNLID LLWQKQPAIP HNPLLALSTS FAGCTVAEKL
ISVRSKLAEK RASVLVVSAL DEIAWLLNLR GTDIDYNPVF FAYVIVTPEQ LHLFIDPVQI
VPPVLEHFGA NGVEVQVHAY DEVHTLLKQL AEASSQLVWI SSGSSYALTA LIPEEKRFHD
ITPIQLMKAV KNETEAQGMR DCHRRDGVAL CQYFAWLERT LATGGTVDEI SGATQLEHFR
SVQQHYQGLS FTTISASGPN GSIIHYHPLP ETNRPITDRE LYLCDSGAQY LDGTTDVTRT
MHFGTPTAEE IRAFTYVLKG QIALGTAIFP RKVKGQFLDT IARKALWDIG LDYGHGTGHG
IGHFLNVHEG PMGIGIRLMP NDPGLEENMF LSNEPGYYKD GQFGIRIEDI VQVITANVGT
NFDGRGALAF STITMCPIQT RLIDVTLLTP AERQHINSYH ERVRDQLLPL LREANDAETI
AWLQRETEPI
//
