ID W5JT65_ANODA Unreviewed; 601 AA.
AC W5JT65;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Arylsulfatase B {ECO:0000313|EMBL:ETN66473.1};
GN ORFNames=AND_001740 {ECO:0000313|EMBL:ETN66473.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN66473.1};
RN [1] {ECO:0000313|EMBL:ETN66473.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN66473.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN66473.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC001740-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; ADMH02000442; ETN66473.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JT65; -.
DR STRING; 43151.W5JT65; -.
DR EnsemblMetazoa; ADAC001740-RA; ADAC001740-PA; ADAC001740.
DR VEuPathDB; VectorBase:ADAC001740; -.
DR VEuPathDB; VectorBase:ADAR2_008097; -.
DR eggNOG; KOG3867; Eukaryota.
DR HOGENOM; CLU_006332_10_1_1; -.
DR OMA; NDPCERY; -.
DR OrthoDB; 2913702at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF264; MIP05773P-RELATED; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..601
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010155943"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..353
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 601 AA; 66809 MW; E57403BB37390E1B CRC64;
MKLDSIKCLT GVVIVSLTVS LVVAAASSPN IVIIVADDLG WNDVSFHGSN QIPTPNIDAL
AYDGVILNRH YVPPLCTPSR ASLMTGRHPM NVGMQNDVII SDQPWGLGLD QKLMPQYFRE
AGYRTHLVGK WHLGFFRQAY TPTRRGFETH FGYLGPYIDY WDHSLQMNAT SARGLDMRRN
TAVNYDARGT YATDLFTTEA TRLIRTHNTT DPLFLVLTHL APHTGNEDDP MQAPAEEIAK
FAHIKDPKRR TLAAMISRVD VSVGMVYDAL RERKMLDNTI ILFYADNGAP TVGIHANSGS
NYPLRGQKSS PWEGAVRGAA LLWSPLLTRK GYVSEQLIHV SDWLPTLARA AGIRNIPLQD
SAIDGQDQWT ALQSGAVDLK PVRSIVMNNA EDSCHFSSYV KHGWKYVNGT CSDGEYDGWL
GDMVQPDQDE LQLSDADYYK QLTIPGSIGA ALNLSREQAE KLRAEATLKC APHSPDDIPC
NPLIAPCLFN LHEDPCERVN QAAKHPVLLA TLKAEVLYYR LRSAKPRNQP PDSRSDPARF
NYTWTWWQEE LEARQTAADI ALASLVAEVV LVLFAVGLAL KLCWCYCRQK VEPSPAPKAK
T
//
