ID W5JUT4_ANODA Unreviewed; 917 AA.
AC W5JUT4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Leucine-rich transmembrane protein {ECO:0000313|EMBL:ETN68112.1};
GN ORFNames=AND_000052 {ECO:0000313|EMBL:ETN68112.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN68112.1};
RN [1] {ECO:0000313|EMBL:ETN68112.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN68112.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN68112.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETN68112.1}.
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DR EMBL; ADMH02000009; ETN68112.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JUT4; -.
DR STRING; 43151.W5JUT4; -.
DR VEuPathDB; VectorBase:ADAC000052; -.
DR VEuPathDB; VectorBase:ADAR2_007364; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_006000_1_0_1; -.
DR InParanoid; W5JUT4; -.
DR OMA; VKYFCII; -.
DR OrthoDB; 21383at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF550; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ETN68112.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 636..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 703..851
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 559..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 104336 MW; A67D949D20585173 CRC64;
MMVSDGQVWR YVCHLLVVLL KVRSAWFLIG ISLHPWLPVA TTVSIQVNYD TGQVSDGPLF
HLPEQIAAIS IKEELMKLKG PDSYLADERE CILGQASFYL TDWLMANATI NRANPELHGK
YIDMSYQNTN IRRHFFIVML TNNVTEIAYV SLAHRNMTVV PCEELQMINS SISHLSMAGN
NFYTVKLPIL QNLLVLDLRN CALITLAYEV FATVPHLEQL YLSHNYLLQL TALHMRPLSA
LRHLDLAYNS NGNQGTYQAL GGLEAVPDPY TILTEGMQLS DDVFDPLKRL TFLDLSHTKL
LPTSARAFRN LAVEQLSLCY TGISIIVGSM MYGILRTLDI SGNPGITAAI HRDANVGNTR
GLNGNIEILA CENASVKYLD WVHGMVNLRV LLLGYNSINQ LTNETFATLG RLEVLDLNAN
HVSNWHWRIF AHNPALAVLD LSANNLNVLT TEMLSDFERV RFLAIGENNF ICHCLLRDFL
DMASFSPSGI GCAIRAMGQY FLGIGTSIGT TRTANITDEN AATDGQATIK VKAHSRLALR
WHRSQARFGS FHELNCSTGY SSEDDREKAV LNDDEGNDTG DSSERIQLID YHAETYRCRD
VENVVHDFID LERCTFDRAA LGGLLFNDIN DTAATVVKFV LLFFGFALIA FIIYISKWEY
VKYFCIIVRN ATILSLMRHK REHLVKKNTA NRRPSAIPGG DLFVYDVFVS YSENDRSWVL
NELLPNLERS EDIAVCLHER DFKVGVSILE NIIHCMDRSR TLLLVMSESF LLSHWCQFEM
HLAQHRLLET RREHLILVLL EEIPKMKRPK TLHYLMKTKT YIRWPTENTT DNWDESRPGD
KRVRYNWRSI PWLGRLGTRR MNSTTGTNDS YCSNVSSSSS TSTLNLERKL FWMRLKRSIH
DGINWEPEDD RGRSSQA
//
