ID W5JVR4_ANODA Unreviewed; 2024 AA.
AC W5JVR4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=[histone H4]-N-methyl-L-lysine(20) N-methyltransferase {ECO:0000256|ARBA:ARBA00012188};
DE EC=2.1.1.362 {ECO:0000256|ARBA:ARBA00012188};
GN ORFNames=AND_000673 {ECO:0000313|EMBL:ETN67513.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN67513.1};
RN [1] {ECO:0000313|EMBL:ETN67513.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN67513.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN67513.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC000673-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADMH02000172; ETN67513.1; -; Genomic_DNA.
DR STRING; 43151.W5JVR4; -.
DR EnsemblMetazoa; ADAC000673-RA; ADAC000673-PA; ADAC000673.
DR VEuPathDB; VectorBase:ADAC000673; -.
DR VEuPathDB; VectorBase:ADAR2_007492; -.
DR eggNOG; KOG2589; Eukaryota.
DR HOGENOM; CLU_233519_0_0_1; -.
DR OrthoDB; 5396777at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140941; F:histone H4K20me methyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd19186; SET_Suv4-20; 1.
DR Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR039977; Suv4-20/Set9.
DR InterPro; IPR025790; Suv4-20_animal.
DR InterPro; IPR044426; Suv4-20_SET.
DR PANTHER; PTHR12977:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B-RELATED; 1.
DR PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 153..264
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..962
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1892..1910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2024 AA; 220947 MW; 60548FE95BDD10DD CRC64;
MVVSSSGHGG GGGGGSNSGG NSAGSGGHQA GGSTRSNSQR LALATPGTGM TPKELSDNDD
LATGLVLDTI LGFQTHKMSL KYRPLKADKD EIKMIIEEFI RTQNYSKCYQ QLLAGSWMPR
SVLNKNKLAL KRLETHIYLY LRVFDQHSGF VIEPCYRYSL EGQKGAKICS TRRWLRHEKI
VCLVGCIAEL SEREEAMLLH PGRNDFSVMY SCRKNCAQLW LGPAAYINHD CRANCKFVPT
GRDTACIEVL RDIEAGEEIT CFYGEDFFGD NNCYCECETC ERRGTGAFMA RAAEAFAARG
LFGVGTEADR TLIVNGAVSS LMNDGTGAGL RLPNAIDSIA PGGVGVNGIP IGSTVRYRLR
ETDNRLNRMK SKGMGVGGTV YSSVVNAAAV GEVMGKVAGL GRDPSLGLTL KELREKGMTK
YDAEMLLAQQ KHHQTLSYCP GARGTISNIR NNTNNNNSST TTTTSSTSSS TSAIVNDSLK
NDELRENAAI TEVRSTPDAQ LKRATRGKTS TKSSTTTKQQ ANLMRNSAEQ RINKTRRHST
HANLAVDAIE ESQLKQRKES IRDRRKSCAL PSAATVETII ADDYDYYDGA YSQLDKLLAL
DALDDERAMA AYKLAYQQQY NSPKRLEIGQ RRGLRERGQQ RRQRKRSTDE CSLSLVADSI
VPDDVSPRVT RGMLRQREDY GSRGSSGGGA SNDLRVSVMT TPADHGTMAE EKVSRPKSKS
ATSSSASSNG IVTRRMSRCL GLLNSSAISA TDGGEHDVRD AATTLTATAP MPPISVAIVS
NLGSRIVTRR MSRRKSLASS GLVGGGEEND GVASSAAITM ANHSSNRGNR RKQHLHKRNV
DDEDNGVGRR AAEKESKNDH HPIEDDWMRK HKKRACQTST TSAAVVMSSE RHFAKPRQRK
TADTVTDAGC PVTTASHTEG TVKRNEMQNS ARANLASRWN DDNEEQQENN DGDADDDEDD
EDDLCLSEII RSARNHTVTS SSDSNTKGDL KNLSSRVGDP QKDRKLATTR FPGTAHKQLH
VAKYAPENFE GSYYLRQSQQ SPSVQQHTVI ELASSIPSQP PGSSFPSPQQ PKQQWPTVTD
SVLSTPERRV KLTLRMKRSP VIDEIIESGQ SLGENNGTNA CSFPREYEIL RTEGIGREFD
SDSEEEQACE RRSRPRKKRQ LQLDEQKTEQ NGQVQHQQKA VVIEGNEKRE EREQDELAED
EEDLTSYSSS CSSRMSQKHS KRHKASKEAR RLRKLEKRER RRQLSCSSNL SSVTAYSQGG
WPYSDDGPPG AHETDQSAFV LSSSSMNTRR AVNQTIAPVS LPKESGNNQP GVVPLFRNGL
RSSSSLQSGP MMVPPQWRVG SVSPPQPNPP QPAKRLRLIL RNETHTRDIP PTAEAMVQKA
DLPTVVAQQL EISETKSSRS RRHSTHASFL LCPTSDCQNG GLSTISTVAP NYNTTPNTSS
LTSLSSNNAS AKDEIESGAH HDSNQSIVTA SSRRPTALQS TTDQQYKTVA PSQGDGNLSQ
PEPVLAALFQ NSSSPLAHLQ RPSMDPPAGC VNTASTKRLS TPHVKRERVV TVKSTQVQPD
LLLPVVAKAR TEKVQQDETY DCQPGPRKSR SRRHSTHGNI LTSASSDSDS GESEVQTRAN
EQQASSNAKH DAGIQQRTVR RRSCGVTSVS TLTMNHHDAG TQIDSNLAVE RNASTQANPL
SVMIPAQGLD PMVSSTHVST SRNAIFISKR TLSKRRITLD EARQLVHAWK MKLDHHNTLV
HDGDDKAIVP NSGALGTSQE RENRSETLIC NTPGVIVCHV TDRRDPSSSI NGVLAPVISS
PLQSESSCSL TPIIGDTAGC SSNCATEKAA IHSGSGALLN LAVSNPSSLP TTSTRPLPAR
LRQVLEQGLS FASNLAGNLP VLHDNRSQEK QPHVITTRNS SNSGDASTNS PVADNISTYL
TQFQHRSKQP ALAFQRNGHS PSMEVSVVAP SRMLNHDNVP KSIRHSSRSE SVVPLQMRPK
MRSTLPEDII GRILVTLVHQ QHPVLYSRYR ASWNTANKLG LQSG
//
