ID W5JVW6_ANODA Unreviewed; 917 AA.
AC W5JVW6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Unkempt protein {ECO:0000313|EMBL:ETN67603.1};
GN ORFNames=AND_000572 {ECO:0000313|EMBL:ETN67603.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN67603.1};
RN [1] {ECO:0000313|EMBL:ETN67603.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN67603.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN67603.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC000572-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the unkempt family.
CC {ECO:0000256|ARBA:ARBA00008808}.
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DR EMBL; ADMH02000148; ETN67603.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JVW6; -.
DR STRING; 43151.W5JVW6; -.
DR EnsemblMetazoa; ADAC000572-RA; ADAC000572-PA; ADAC000572.
DR VEuPathDB; VectorBase:ADAC000572; -.
DR VEuPathDB; VectorBase:ADAR2_000464; -.
DR eggNOG; KOG1100; Eukaryota.
DR eggNOG; KOG1595; Eukaryota.
DR HOGENOM; CLU_014526_1_0_1; -.
DR OMA; ADNYCPK; -.
DR OrthoDB; 1388186at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16614; RING-HC_UNK-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045234; Unkempt-like.
DR InterPro; IPR040594; Unkempt_Znf.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14493:SF118; RING FINGER PROTEIN UNKEMPT; 1.
DR PANTHER; PTHR14493; UNKEMPT FAMILY MEMBER; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR Pfam; PF18384; zf_CCCH_5; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR PROSITE; PS50103; ZF_C3H1; 3.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 76..100
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 231..265
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 273..301
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 875..910
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT ZN_FING 76..100
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 231..265
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 273..301
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 395..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 99940 MW; 14DDDA515ACB6679 CRC64;
MASADPTKSL FTTQTEKPNH YTYLKEFRVE QCPSFLQHKC NQHRPFVCFN WHFMNQRRRR
PVRRRDGSFN YSADNYCPKY DETTGICPDG DDCPFLHRTA GDTERRYHLR YYKTCMCVHD
TDARGYCVKN GHHCAFAHGI HDQRPPVYDI KELEALQNAD VTGEGGLNGP NVLDKERNLM
NEDPKWQDTN YVLAHYKTEP CKRPPRLCRQ GYACPQFHNS KDKRRSPRKY KYRSTPCPNV
KHGEEWGEPA NCEAGDNCQY CHTRTEQQFH PEIYKSTKCN DVQQAGYCPR SVFCAFAHVE
PYVVTEEMSL RGDLDSQTLA LSDMLSSVLP TGDGSGAVGG APGSSVLSAL GGNAGSVPPG
TGAGSIGSGV KKEVTHELAN LSYFQLLQNG SAESSESAST SSLGSNHSSH NKAPGAQLQQ
QKNNGGTGSN NSSMLGNNGH GGSGGGSGTG PLCGLGLLSN GGAGANGVNG GVPTTGSSLL
SSIDFNSDLP KQLVAIENDL TLNPLNPLER KRIWNQLCNI GSPLDGGMFE LGRRETIHGL
DNPISSGLAS TGLLASSSAP VNIPGSPMGN SISGLLQGTS APVNIPGSSL GHNFSPSSHS
NLFGLNDPFG GPPSHHHHHH IGSGSAPKLG NRGNSYGGHN HTDNLFFQSH IISPGLGDGL
SASPEIRRIT ELNPLSGELG STTNNLLFTD SQHHQVQQSQ QQQQQQQQQQ QQQQQQQQAA
AAPATATTAN AASSCRSCSG RSRPVQQQQQ QQQQHQQQQQ QQQQQQQQQQ QQILNWEEHV
LHATNACEAW KAQMEESNRK TAIAEQQRDE ALSHVKALKE KLEQLSIGGG NSISNHRTND
LRGMSLPKLK SIQAKLRAEI EEVEKVLYLE TATKCMKCEE NNRSVTLVPC NHYVLCDACA
ATQRECPYCQ TPVASQS
//
