ID W5JYW2_ASTMX Unreviewed; 795 AA.
AC W5JYW2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000522.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000522.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR AlphaFoldDB; W5JYW2; -.
DR STRING; 7994.ENSAMXP00000000522; -.
DR Ensembl; ENSAMXT00000000522.2; ENSAMXP00000000522.2; ENSAMXG00000000517.2.
DR eggNOG; KOG2189; Eukaryota.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR InParanoid; W5JYW2; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000517; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF90; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 2.
DR PIRSF; PIRSF001293; ATP6V0A1; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 405..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 441..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 546..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 573..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 608..624
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..655
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 676..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 732..753
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 91..118
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 795 AA; 90563 MW; 8D9EAE0C2F18FD31 CRC64;
MFRSEEMCLV QLFFQTESAH TCIHQLGLLG LAQFRDLNPG TAAFQRKFVK EVKRCEEMER
ILRFLEAEMA RCAIPVSAVV DSGGVTCPRE LLELECKIRK LEEELKEINC NHDALKRNFT
ELLEISSLLK ASRDFFEEAE SQLSSSELPS EDSVSIATIR RNSSASTSGP QKLGFIAGVI
KQDRFPAFEK VLWRLFHENF ILRHAEIQDT EQQTENTMVK KDAFVIFVQG DQVQGKIKKI
CDGFRASLYP CPNTLSAREQ MRMSVHIRIE DLRMILRRTE EFRATVLTKA ATSIQHWVNK
VKKMKAIYYT LNLCNIDITQ KLIVAEIWCP VSDLNSVQNA LIKGSEQSGS SVSPILNRIH
TQHTPPTFNR TNVFTKGFQT IVDAYGVSNY REVNPTPYTI ITFPFLFAVM FGDCGHGLVL
TLLAVWVIVQ QKKLSCCRSE FVVVLVEGRF IILLMGLFSI YTGLIYNDCF SKSFSIYGSS
WSVRHMFQPS GPWSNETLHS SGHLTLDPAV PRVYSGSPYM LGIDPVWNIA SNKLSFLNSY
KMKMSVILGV SHMLFGTTLS LVNYIHFRNF QNILLRFIPE LVFMLSLFGY LIFLIVFKWC
VQLRSETAPS ILLMFINMML FSYQSSDVFL YSEQKAVQTF LVLQALLMVP VMLLVKPLLI
YRQRIKLRLQ ESMGDIFAYQ AIYTIEHCLG CISNTASYLR LWALSLAHAE LSEVLWRMLL
RSGLRCNPGL GSVLLALVLC CFALLTVAVL IVMEGLSAFL HALRLHWVEF QNKFYQGAGF
KFTPLSFTSL LKTQP
//
