ID W5K090_ASTMX Unreviewed; 881 AA.
AC W5K090;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=E3 ubiquitin-protein ligase RNF31-like {ECO:0000313|Ensembl:ENSAMXP00000001000.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001000.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001000.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K090; -.
DR STRING; 7994.ENSAMXP00000001000; -.
DR Ensembl; ENSAMXT00000001000.2; ENSAMXP00000001000.2; ENSAMXG00000000984.2.
DR eggNOG; KOG1812; Eukaryota.
DR GeneTree; ENSGT00530000064112; -.
DR HOGENOM; CLU_016614_0_0_1; -.
DR InParanoid; W5K090; -.
DR OrthoDB; 2909614at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000984; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR CDD; cd20337; BRcat_RBR_HOIP; 1.
DR CDD; cd16631; mRING-HC-C4C4_RBR_HOIP; 1.
DR CDD; cd20351; Rcat_RBR_HOIP; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047540; BRcat_RBR_RNF31-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR047542; Rcat_RBR_RNF31-like.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR047541; RNF31_RBR_mRING-HC-like.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16004:SF3; E3 UBIQUITIN-PROTEIN LIGASE RNF31; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF05743; UEV; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS51322; UEV; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 5..149
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 453..690
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 457..506
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 150..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..854
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 99422 MW; 0D1621B8555F468C CRC64;
MSLVTPDLEY KTLAECNYAF PTEVLADIKE VETAFPDLQL HVEFYYYPNN DRKKLVNLRG
TVPIVYEGNK YNIPVCIWIH ETHPQNPPRC YVCPVSSMVI NSRSSSVDAR GHVRLDCLSN
WKTGWSNLSI VLEEMVAAFQ RETPLFATPP VRAAKLPPGT KHLPAEWHDH PKTSSTHGSW
PQAGSNSAQR KSSHPEMSSS SISHSASNML PKSAKDAAEG SGVKRSYTQE LLDFGITFSA
PDVQSRPPTN PFISSATAPN TNVSNPDDLD NMFKSLQLER VVNMYQLDHR DQDIPHAWRQ
SQGHEDGRLV QPGLLDNRHR VLISHLPVGV SPNKIKNKLT IYFQRKLNGG GEVVAVIYPS
VQPDQAVVTF RHYRDAEYVL REPNRVIAVD DQQVFIQLKK FEGSEVLIPE GVRGEKAEMF
RSILSLGDCN FNPADVLEAV QACRDLPSAL KYLSHDCPIC QEQMSFGKMI TMTHCSCTFC
ESCFKAYFSS VIKEKSIVHA VCPMCNQPDV RGAGRREESM EYFSLLDTQI RHYLDPQTHE
LFQRKLRDQA LQEMPNFRWC AHCSFGLLHE ADRLRMDCPN CGKSTCFNCK SPWASQHEGL
SCEKFKEWQQ LNSPEYQNSR LELLLSRNKI DCPKCRFRFF LSKGGCLHFK CTQCQHEFCG
GCSRPFRNGS ACNFSAECGT KGLHAHHPRD CLYHLRDWDV ARLCSLLQHH GVAHPLIYSQ
RDGSVLGSQR VVCAVFEHKE LGSPREEPCG RVALPEYNGY CTLHYKECLV ELIKQNGLDP
VVLFTEPELR AELDRWKIPV PEKQPPESDR LYSDRLRQIL VQRVGLTRPS AAAASQLKPS
VPPTPSPSPS TPPAAGAPWY SVLNPGRALP EDTQLLLLLN D
//
