ID W5K1G5_ASTMX Unreviewed; 377 AA.
AC W5K1G5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Bone morphogenetic protein 2-like {ECO:0000313|Ensembl:ENSAMXP00000001425.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001425.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001425.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; W5K1G5; -.
DR Ensembl; ENSAMXT00000001425.2; ENSAMXP00000001425.2; ENSAMXG00000001399.2.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000165063; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001399; Expressed in embryo.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13765; TGF_beta_ADMP; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF241; ANTI-DORSALIZING MORPHOGENETIC PROTEIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..377
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017406040"
FT DOMAIN 259..377
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 377 AA; 42898 MW; 388DC64F0542F2A7 CRC64;
MPYIRFKLLS PVLLFLEFAL KQPDMPSEEV RSAAIKRLLE VFGMEDPPAT PPRSHKQPPQ
YMLDLYNTVA DVDGVTKDPT VLEGNTVRSF FDKLRSDQIE YLFNLTTVAR SEKLLTAELH
LFKLRPQASL TFNRHHFCQV NVYQVLDTSK MNISHNKKLV SSRLIPIHSN GWEVFTISQA
IRTWTMSHHS NLGLLVTVRT LSGNQMDLRT VRFASGQNHH HTKQPMLVLF TDDGRRAAPM
EAVPSLPLPS LTLPVVGHRI PRSLDYEEDR ERLPCQRLPL YVDFEEIGWS GWIVSPRGYN
AYHCKGSCPF PLGQNMRPTN HATVQSIINA LKLTKGIETP CCVPDKLFSI NLLYFDDDEN
VVLKQYDDMV AGSCGCH
//
