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Database: UniProt
Entry: W5K1Q2_ASTMX
LinkDB: W5K1Q2_ASTMX
Original site: W5K1Q2_ASTMX 
ID   W5K1Q2_ASTMX            Unreviewed;      1969 AA.
AC   W5K1Q2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001512, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000001512, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000001512};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000001512}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000001512}.
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DR   EMBL; APWO01101751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007254292.1; XM_007254230.2.
DR   Ensembl; ENSAMXT00000001512; ENSAMXP00000001512; ENSAMXG00000001489.
DR   GeneID; 103042615; -.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; LYWVNFV; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    130    153       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    351    370       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    390    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    738    756       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    768    786       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    848    876       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    938    961       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1203       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1224   1243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1255   1275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1301   1327       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1424   1450       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1509   1527       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1539   1561       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1573   1592       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1661       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1682   1701       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1729   1752       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      497    684       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      738    965       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      975   1178       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1183   1458       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1508   1762       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    452       {ECO:0000256|SAM:Coils}.
FT   COILED      486    507       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1969 AA;  223744 MW;  2CA6D58A6D7BE725 CRC64;
     MAAPLLAPPG PDSFKRFTPE TLANIEKRIA EEKKKKPVKP RSDSSHRDDD DESGPKPNSD
     LEAGKSLPFI YGDVPSEMVA VPLEDLDPFY LNKKTFIVLN KGKTLFRFSA TPSLYIISPF
     SLFRQIAIKI LIHSLFSMII MCTILTNCVF MTFSNPPEWS KQVEYTFTGI YTFESLTKIV
     ARGFCIDGFT FLRDPWNWLD FMVISMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK
     TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR QKCVFWPISN LSVTYLANGS
     KGFDFDEYIM NDTNFYFLPG QLDALLCGNS SDSGRCPEGY TCMKAGRNPN YGYTSFDSFG
     WAFLALFRLM TQDFWENLYQ LTLRAAGKTY MIFFVLVIFV GSFYLVNLIL AVVAMAYEEQ
     NQATIEEAEQ KEAEFKAMLE QLKKQQEEAQ ANAMATSAGT VSEDAVEDDG GGRLSRSSSE
     VSKLSSKSAK ERRNRKKKMR KEQEKEKGDS EKVVKSESDD GSKRSRFRFP DNRLGRKTSI
     MNQSLLSIPG SPFMSRHNSR SSIFSFKGRS RDVGSENEFA DDEHSTVEES EDRRGSLFIP
     YRRNSYSGYS QGSSRINPLA PHSGCKRNST VDCNGVVSLI GPGPGRLLPE TTEVDVKRKH
     SGSLMVSVDQ LNTSFGRKER ANSVMTVITN TLVEELEESQ RKCPPCWYKF ANTFLIWECC
     PIWIKIKEIV NLIVMDPFVD LAITICIVLN TVFMAMEHYP MTEQFENVLS VGNLVFTGIF
     TAEMFAKLIA MDPYYYFQEG WNIFDGFIVS LSLVELGLAD VEGLSVLRSF RLLRVFKLAK
     SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKSYKDCVC KIAQDCELPR
     WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQTMCLTV FMMVMVIGNL VVLNLFLALL
     LSSFSADNLA ATDDDGEMNN LQISVIRIKK GIAWLKIHVR LLVAHVLKKA PLEDEDKPLD
     DMYDKKLNII GNHTGVDIKC GDLDFAKNGN GTTSGIGSSV GKYMIDEDRM SFIHNPNLTV
     RVPIAVGESD FENLNTEDFS SESDVENSKD LDDTSSSEGS TIDIKPDEEE VAAVEVVEEY
     LDPEACWTDA CIARYKCCDV PITEGWGKYW WYLRKTCYLI VEHNWFETLI IFMILLSSGA
     LAFEDVYIEQ RKTIQIILEY ADRVFTYIFI LEMLLKWVAY GFVKYFTNAW CWLDFFIVDV
     SIVSLIANAL GYSDLGPIKS LRTLRALRPL RALSRFEGMR VVVNALVGAI PSIMNVLLVC
     LIFWLIFSIM GVNLFAGKYY YCFNETSEEY FEPDEVNNKT ECFNLIEQNF TEVRWKNVKI
     NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRKVEDQPLY EDNIYMYIYF VIFIIFGSFF
     TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPQNKIQGV
     VFDFVMQQAF DISIMMLICL NMVTMMVETD DQSDETENIL YWVNFVFIVA FTGEFVLKLF
     ALRHYYFTNG WNIFDCVVVI LSIVGMFLAD LIEKYFVSPT LFRVIRLARI GRILRLIKGA
     KGIRTLLFAL MMSLPALFNI GLLLFLVMFI FSIFGMSNFA YVKRELGIDD MYNFETFGNS
     MIILFMITTS AGWDGLLAPI LNYPPDCNPE KENPGTTVKG DCGNPSVGIF FFVMYIIVSF
     LIVVNMYIAI ILENFSVATE ESADPLCEDD FESFYEIWEK FDPDASQFIT FAKLPDFADT
     LEHPLRVPKP NIIELIAMDL PMVSGDRIHC LDILFAFTKR VLGDSGDLDM MRQQMEERFV
     AANPSKVSYE PITTTLRRKQ EEVSAVVIQR AYRAHLARKG FVCKRRPANN KLENGGTNQE
     KKESTPSTAS LPSYDSVTKP EKEKQDDNNE GKGRKEKGRN QKDVRESKC
//
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