ID W5K2Q5_ASTMX Unreviewed; 799 AA.
AC W5K2Q5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 3 {ECO:0000256|ARBA:ARBA00020976};
DE AltName: Full=Component of oligomeric Golgi complex 3 {ECO:0000256|ARBA:ARBA00031339};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001866.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001866.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in ER-Golgi transport.
CC {ECO:0000256|ARBA:ARBA00002090}.
CC -!- SIMILARITY: Belongs to the COG3 family.
CC {ECO:0000256|ARBA:ARBA00009936}.
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DR AlphaFoldDB; W5K2Q5; -.
DR Ensembl; ENSAMXT00000001866.2; ENSAMXP00000001866.2; ENSAMXG00000001820.2.
DR eggNOG; KOG2604; Eukaryota.
DR GeneTree; ENSGT00390000015682; -.
DR HOGENOM; CLU_011639_1_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001820; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR InterPro; IPR048685; COG3_C.
DR InterPro; IPR048320; COG3_N.
DR InterPro; IPR007265; COG_su3.
DR PANTHER; PTHR13302; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3; 1.
DR PANTHER; PTHR13302:SF8; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3; 1.
DR Pfam; PF20671; COG3_C; 1.
DR Pfam; PF04136; COG3_N; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 129..271
FT /note="Conserved oligomeric Golgi complex subunit 3 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF04136"
FT DOMAIN 279..612
FT /note="Conserved oligomeric Golgi complex subunit 3 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20671"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 91211 MW; A6252AF247E685BB CRC64;
MMKMKPERDG DGERESRTEP RGEERAEERS GWSSLTHKQS ESVEEIRRSA ESLELPSELP
IEDLCSLPSR SLFPAAIPAS TEDVLLKGFQ MLDMEDRRIE TAQQFFSWFS KLQAQMDQDE
GAKYRCVTRE CLSCYQDQCD AILTDVSAAL EHLDSLQKQY LFVSTKTGTL HEACEQLLKE
QSELVDLAES IQQKLSYFNE LENINTKLNS PTLSVNSEGF VPMLSKLDDC IEYVSAHPNF
KDHPVYLAKF RQCLSKAMQL IRTHAVSTLQ NLTSQLTKRT LIEQVEQRSE KIPEYQQLLD
DIHQSYLEQR EALLSPSINS TITDLTSQSN KDHCALVRSG CAFMAHVCQD ENQLYSEFFS
KPTAKLDELL EKLCLSLYDV LRPLIIHVVH LETLSELCGI LKNEMLEDHV HNNTVQLGAF
EAVVKQMLED VQERLVYRTH IYIQTDISGY SPAPGDLAYP EKLQMMEKIA QSLKEEQLRL
NSPDSSFSDV QLEDPESRKL ISSGQCKRNS RVPASVSPAD LHGMWYPTVR RTLVCLSKLY
RCIDRAVFQG LSQEALSACI QSLLKASEDI LKNKSQIDGQ LFLIKHLLIL REQIAPFHAD
FAIKEISLDL KKTRDAAFKI LHPKAVPKFF RLNSHNAILE FLLEGTPEIK EHYIDSKKDV
DRHLKSSCEH FIQQQTRMFV GSLEEFLTKV AALKTMAIQG GPTYNLSQQP WAQPAKINDL
VMSMYRVMKN KVPGTLQSMS LYLANKDTEF ILFKPVRNNI QQVFQKLHNV LQEEYSGEDL
QIIACPSMEQ INLLLSVSK
//
