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Database: UniProt
Entry: W5K2W7_ASTMX
LinkDB: W5K2W7_ASTMX
Original site: W5K2W7_ASTMX 
ID   W5K2W7_ASTMX            Unreviewed;      2722 AA.
AC   W5K2W7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   22-NOV-2017, entry version 20.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 1a {ECO:0000313|Ensembl:ENSAMXP00000001928};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001928, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000001928, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000001928};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000001928}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000001928}.
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DR   EMBL; APWO01101765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01101771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000001928; ENSAMXP00000001928; ENSAMXG00000001795.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DPDDHYQ; -.
DR   OrthoDB; EOG091G00T2; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF08709; Ins145_P3_rec; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 6.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2252   2270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2282   2300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2321   2345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2365   2393       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2414   2436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2543   2566       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      167    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      373    429       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2667   2701       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2722 AA;  310343 MW;  14A112E89CADF51D CRC64;
     MVDKMSSFLH IGDICSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHVKKNTNH KENDRQQKEI CGTHLETLKH
     TKPYIAIDSH RQSLQYMHYI QTLIKSSGIK SYYFFTFQLN RLNSVHTLQV VIGDKVVLNP
     VNAGQPLHAS GHQLVDNPGC NEVNSVNCST SWKIVLFMKW SDNQEVVLKG GDVVRLFHAE
     QEKFLTCDDH RKKQYVFLRT TGRQSATSAT SSKALWEVEV VQHDPCRGGA GYWNSLFRFK
     HLATGHYLAA EVNPDYEEEC LESRSSLDSE HEVIRARARN PQDKVMYTLV SVPDGNDISS
     IFELDPTTLR GGDSLVPRNS YVRLRHLCTN TWVHSTNHPI DKEEEKPVML RIGTSPLKED
     KEAFAIVPVS PAEVRDLDFA NDASKVLASI AGKLEKGTIT QNERRAVTKL LEDLVYFVVD
     IPNSAQDVLE ITVNKPNRER QKLMREQNIL KQIFKLLQAP FTDSGDGPML RLEELADQRH
     APFRHICRLC YRVLRHSQQD YRKNQEYIAK QFRFMQKQIG YDVLAEDTIT ALLHNNRKLL
     EKHITAAEID TFVSLVRKNR EPRFLDYLSD LCVSMNKSIP VTQELICNAV LDPANGDILI
     ETKLVLSRFE VAGAVLGEST EDEEEDEEEV WLFWKDSSGE VKSKSIRELA QDAKDGHTED
     QEVISYYRIE YTHDLISALL LEAQYLDLLS SGSTAVELAI SCWSPERAQL ALLSLGNRTL
     VGCGTMGDSQ KTPLKYLRNS GTDFYKRPIQ ELLTSAGMSE ALFVFEKAVV INFQTVDDMY
     LNSYRFSEQS NNFTFYDVHL TLFRICSHSF SFSMLLIWRR NRTSQKTRSC WELSFSKTVL
     SLTKHKLNTC NTVLQQLKSN KYLTVNKRLP ALLEKNAMRV TLDAAGNEGS WFYIQPFYKL
     RSIGDSVSTV QEWEKFNNQV QSEDFVQEFC GPTKKISKGS NTSWTHCSYV PLSHTVELFA
     GGRGCADAAT LSIKMNGMHC AGGRERMRLD LISSRGKQNI VCGLQNFFSY MSSCVVQVQL
     LVTSQDVENY KQIKADLDQL RSIVEKSELW VYKRQGSDSG LHTGEGIASE THHKSDSISD
     GMDKPKVEST SSSNYRLMKE ILLRLSKLCV MECLSGRKNK KQQQRLLRNM GAHSVVLELL
     QIPYEKGEDV WMQEIMTLAH QFLQNFCAGN QQNQTLLHKH INLFLNPGVL EAVTMQHIFM
     NNFQLCSEIN ERVVQHFVHC IETHGRSVHY LKFLQTIVKA ENKFIKKCQD IVMAELVNAG
     EDVLVFYNDR ASFQTLVQMM RLERERLDDN SALRYHIHLV ELLAVCTEGK NVYTEIKCNS
     LLPLDDIVRV VTHEDCIPEV KMAYVNFLNH CYVDTEVEMK EIYTSNHMWK LFDDFLVDIC
     RVCNNTSDRK HADTVLERYV TETIMSIVTT FFSSPFSDQS TSLQTRQPVF VQLLQGVFRV
     YHCNWLLPSQ KGSVEGCIKV LSDVAKGRAI AIPVDLDCQV NNLFIKSNNI VQKTALSWRL
     SARNATRRDS VLTASRDYRN IIERLQDIVS ALEERLRPLV QAELSVLVDV LHRPELLFPE
     HTEAHRKCES GGFICKLIKH TKQLLEENEE RLCIKVLQTL REMMTKDRGY GEKLMTFDVP
     LESTYIPQAK QALASDEEVD VNLPPKQQED QRRGEALRQL LVNRYYGNFR SGGRRDSLTA
     FTNSALTPVS PNKNQSGALS RAEMSLTEVQ CHLDREGASD LVIDLIMNTN SDRVFHESIL
     LAIALLEGGN TTIQRSFFKR LTEDKKSEKF FRVFYDRMKA AQLEIKATVT VNTSDLGNKR
     RDDHGSDRDT PQRRREKDSV VMVTDDAREQ LLEASAVTKK AYGSYRRDAD PEEAYGHTDG
     DRGGGDKGAE QGEMSPVILI MEPILRFLQL LCENHNRDLQ NFLRCQNNKN NYNLVCETLQ
     FLDCICGSTT GGLGLLGLYI NQHNVALINQ TIESLTEYCQ GPCHDNQNCI ATHESNGIDI
     IIALILNDIN PLGRKRMDLV LELKNNASKL LLAIMESRHD SENAERILYN MRPKELVEVI
     KKAYQQGEAD FDEEEENGED HAASPRNVGH NIYILAHQLS RHNKELQLLL KPSGEDQAVE
     CYTKHTAQIE IVRQDRTMEQ IVFPVPHICS FLTSESKLRV YYSTERDEQG SKINDFFLRA
     DDLYNEMRWQ KKLRAQPVLY WCSRNMSFWS NVSFNLAVLI NVLVAFFYPL DSVRDSTLEP
     SLSLLLWVCV LGSLGFVVLL PSPNAVRILV ISSVLRLGFS LGLQHMLSLL GAFNVCNKIV
     FLLSFVGNRG TFTRGYRAMV MDREFLFHLL YLLICTLGLC GHVFFYSLLL FDLVNREETL
     LNVIKSVTRN GRSIVLTAVL GLILVYLFSI VGYIFFKDDF ILEVNRIPNS THATEEGVNL
     ANSFLSEGTC SVENGTCVSV GEEEGMLCPF VCADDVERAC DSLWMCMITV LSHGLRSGGG
     VGDVLRKPSK EEPLFAARVI YDLLFFFLVI IIVLNLIFGV IIDTFADLRS EKQRKEEVLK
     TTCFICGLER DKFDNKTVTF EEHIKEEHNL WHYLYFIVLV RVKDSTEYTG PESYVAQMIK
     EHNLDWFPRM RAMSLVSSDG EGEQNELRCL QEKLESTMRL VSNLTNQLTE LKEQMTEQRK
     HKQRIGLLGN PAHLNINPQQ PA
//
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