ID W5K342_ASTMX Unreviewed; 1446 AA.
AC W5K342;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=DENN domain containing 4B {ECO:0000313|Ensembl:ENSAMXP00000002003.2};
GN Name=DENND4B {ECO:0000313|Ensembl:ENSAMXP00000002003.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002003.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002003.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000002003.2; ENSAMXP00000002003.2; ENSAMXG00000001965.2.
DR eggNOG; KOG2127; Eukaryota.
DR GeneTree; ENSGT00940000160472; -.
DR HOGENOM; CLU_003074_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001965; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF18; DENN DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 36..195
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 187..636
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 162707 MW; 49016B3F771BF52D CRC64;
MTEERCPQLV DYFVVAGLAG ESAPDEECQQ RGGRAVEPVT DLAVIARSLG EEVPEGFTCI
EKTQGGHPAE LSAGLINNPH MFLCYRRGHD KPPILELGVL YEGKEPVKPG WHVMETTPYS
RSASLSSGGP ATHRTFLMYR RAPDSQALNT LGVTDISLLM PSKGEVAPHT FCRVDKNLNT
GMWGPALYLC YKRAVAKANA LVYEAGLISR YPEEDLESFP LPDSVPVFCL PMGVTVESWP
LNTKYQLPVF STFVLTSASG DKVYGAAIQF YEAYPREALS ERQRVRLGLV SVVDRRPITN
RTVQVKKSVC VLSHWPFFTV FQKFLTFVYR YSISGPHVLP IEKHISSFMH NVPFPSPQRP
RILVQLSPYD NLLLCQPVSS PLPLSGASFV KLLQNLGAEN ACTLLLAVLT EHKLLLHSLR
PDVLTSVSEA LVSMTFPLRW PCPYIPLCPL RLADVLCAPM PFIVGVHSSY FDLYDPPSDV
VCVDLDTNTI FQSEDKKPLS WRSLPRKHGK ILFSSLTSLH KTLEKICTPG QEEATLEFLL
TDYDLIYGRQ KQLELEIQEA FLRFMSCLLR GYRSFLLPIT QAPSDRTTDC SSLFNLQGFL
KSRDRTQQKF YTQLTRTQMF TQFIEECSFV SDRHACLEFF DECVQKVDVE KPEEVRLIDL
DEAHSGEHTV FIMPPEEPQE PDGSECPAIY SYETFPILQP DLFDRPQDQL RTPAKGSAPN
SPAPRRTKQE IKLAQKRAQK YSSVPDMWSK CLLGHCYGLW FIYLPTFVRA ESTKVRALHT
AYEVLKHMET RKVVLPDEAV LESKWPSTNQ GGRLRWAKLR NVLLAVAHFR QPIKHRQKSD
SISSRREDFN CNHRPHSSLI RQTSWSGLSE SSSHESLTGP LTKSNSLSSM RASDKLSKTK
LARQALLQNA GIDDPASRKP PVGRRDTATP SPLPPCERVL VRRSDICLSD FYKECAEPET
DCRCQPAERD GRPVEQRETL NRKIVDENYN NVSSPSRGLA GKLQQLLTPT RHRNSGRRAA
SMDDRRSGAN GPSRKAEQRQ SRKAQVAESL LKAKERLYNA TSESSLSVGS DIDLTELPNS
AFSLRKSWDS AQEGAGLEVL MSSCSLCRSC NSLVYDEEIM AGWTSDDSNL NSSCPFCSAT
FVPLLNAEIC DRGPVNSLEQ RNLNLGDDVE SAMRPPSGQD VFLPHLHNGV NELDSSSETS
TYSENSSNTL SSSLGGTPQV TVAYLSPLVL RKELESLLEN EGESVLSQVQ LLDSHSILFW
NLVWYFTRLG LPSNLLQLVR ASPLASQFLQ NSEGTSVRVR LLWDTLTPDT DHWPPLYMLW
RIHSGVQMRN YSWRRHNHPF TLGFLEEVLR WVGMNEVHKA ITLFLETIAK QPGTPRIQRS
LYREFLFLTL AAMGKDHVAA FDKKYKAAYA RLSGSVGREE LRKKRAQPPS PKAVDCRRCF
LLPLEC
//
