ID W5K3Z7_ASTMX Unreviewed; 585 AA.
AC W5K3Z7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Eukaryotic elongation factor, selenocysteine-tRNA specific {ECO:0000313|Ensembl:ENSAMXP00000002308.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002308.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002308.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K3Z7; -.
DR STRING; 7994.ENSAMXP00000002308; -.
DR Ensembl; ENSAMXT00000002308.2; ENSAMXP00000002308.2; ENSAMXG00000002260.2.
DR eggNOG; KOG0461; Eukaryota.
DR GeneTree; ENSGT00940000158170; -.
DR HOGENOM; CLU_019148_1_0_1; -.
DR InParanoid; W5K3Z7; -.
DR OrthoDB; 54465at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002260; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd04094; eSelB_III; 1.
DR CDD; cd01889; SelB_euk; 1.
DR CDD; cd03696; SelB_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR049394; eEFSec_C.
DR InterPro; IPR049393; eEFSec_III.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF21131; eEFSec_4th; 1.
DR Pfam; PF21208; euk_SelB_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 16..218
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 532..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 63955 MW; 4BB2B1CD56EDD915 CRC64;
MADPSANAGD GLLPQILNFN VGVLGHVDSG KTSLARALSS TASTAAFDKN PQSKERGITL
DLGFSAFTVP LPYHLREACG ERAYHSLQFT LVDCPGHASL IRTIIGGAQI IDLMLLVVDV
VKGMQTQTAE CLLIGQLTCS RMIVILNKID LLPSDKKQSA IDKMTKRMHK TLENTRFKGC
PVIAVAAKPG GPDAPDTEEG QGITELIELL KTQAFLPKRD PSGSLLMAVD HCFSIRGQGT
VITGTILQGA LRVNDTLEIP ALKVTRKVRS VQMFRKPVPS AIQGDRVGVC VTQFDPKLLE
RGVVCTPGSL RTLYAAIISV HKIEYYRGAL SSRSKFHITV GHGTVMARVS FFSRVSRSIP
SGASDGSPSE QGMDSFSFEW EFHHQEEFLS SPGETEGKEP QQWALLEFEQ PVTCPPLSLV
IGSRLDSDIH ANTCRLAFHG KLLEGFEDKN YTETTLPKLK ISKDKHKEGA VERVMDDYTV
IGRNLFKKET NLQLFVGLKV TLSSGETGII EGSFGQSGKI KIRVPEGLKE ETKQLLSSSS
KKKGKGGTKN EPAKEEEAKI NSQPIAIHLN FKRYVYDPHK KMVQS
//
