ID W5K5T4_ASTMX Unreviewed; 846 AA.
AC W5K5T4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Junctophilin-2 {ECO:0000313|Ensembl:ENSAMXP00000002945.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002945.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002945.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the junctophilin family.
CC {ECO:0000256|ARBA:ARBA00008599}.
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DR AlphaFoldDB; W5K5T4; -.
DR Ensembl; ENSAMXT00000002945.2; ENSAMXP00000002945.2; ENSAMXG00000002881.2.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000159411; -.
DR HOGENOM; CLU_008078_1_0_1; -.
DR OrthoDB; 5393283at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002881; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030314; C:junctional membrane complex; IEA:InterPro.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR InterPro; IPR017191; Junctophilin.
DR InterPro; IPR003409; MORN.
DR PANTHER; PTHR23085; GH28348P; 1.
DR PANTHER; PTHR23085:SF26; JUNCTOPHILIN-2; 1.
DR Pfam; PF02493; MORN; 7.
DR PIRSF; PIRSF037387; Junctophilin; 2.
DR SMART; SM00698; MORN; 6.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 186..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..566
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 90882 MW; 0505B1A78A7D3F02 CRC64;
MSGGRFEFDD GGAYCGGWEG GKAHGHGICT GPKGQGEFSG SWNYGFEVVG VYTWPSGNTY
EGYWSQGKRH GLGVETKGHW VYKGEWTHGF KGRYGSRVSL ASGAKYEGTW NNGLQDGYGT
ETYADGGTFQ GQFTGGMRHG YGVRQSVPYG MAAVVRSPLR NSLTSLRSEH SNGTLLQQDV
PLITTTNASG QESPSPTPIG PSRGGFALTL HVDPDQVKPK KKGLFRRGSL LGKLTKSESR
TSLSSQKSKL SFLRSDSALS SAASDANSTI SLGESEGEAE GGEFPPVEAD IDATTTEVYL
GEWKNDKRSG YGISERSSGL KYEGEWLDNQ RHGYGCTTFA EGGKEEGKYM HNMLVKAVKK
KLIQLKGTKI KQKVERSVEG AQRAAAIAKQ KAEIANSRTS HAKSKGEAAD QASHGANNES
SIARVVAREL SPSFYQPGPE YLKKRVLQEI SKSNENADTG IHEPLLAEET MPTPPESPFM
HETETLRPNI SPARTPSPGL IPSTAPDPNY LSPGSWNGDK TSRGSGGGSR GGSRPGSKPS
SRPTTPSSAP APAPALEEPP APSSKGPSRT PSRQSAKAEQ GSDLEIKPLQ KPDSELNALE
PVPDSDPAPP PAPVRTSLIS STDEEEPLPR PASKVSSKAQ ATPEPKDVED LEPEPEVPVA
MTETKLEMPN KLETKPSQRR DPSPAPRRDP SPAQRRDPSP APRREPTPVL RRDPSPAPRR
EPTPSLRRDP SPAPRREPTP AQRREATPVL RQEASPSPAQ RRDPSPAPKA VLKPEPKPVP
KPEPKAIAKP PAKVEPKAEL RQRSVVKAPS EVAEATEQDE GPNTIMICMV ILLNIGLAIV
FVHVLS
//
