ID W5K883_ASTMX Unreviewed; 1143 AA.
AC W5K883;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Fibronectin type III domain containing 3Bb {ECO:0000313|Ensembl:ENSAMXP00000003794.2};
GN Name=FNDC3B {ECO:0000313|Ensembl:ENSAMXP00000003794.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003794.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003794.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
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DR AlphaFoldDB; W5K883; -.
DR STRING; 7994.ENSAMXP00000003794; -.
DR Ensembl; ENSAMXT00000003794.2; ENSAMXP00000003794.2; ENSAMXG00000003573.2.
DR eggNOG; ENOG502QRT8; Eukaryota.
DR GeneTree; ENSGT00940000157005; -.
DR HOGENOM; CLU_004152_0_0_1; -.
DR InParanoid; W5K883; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003573; Expressed in bone element and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 4.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 7.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1120..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 276..378
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 382..474
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 611..706
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 694..794
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 707..801
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 901..995
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 999..1096
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 182..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 125252 MW; AC4C59E5C2A02B54 CRC64;
MYVTMMMTDQ MLELPPLLNG EVPVMHHMIN GDASQQVIVV QVNPGETFTI RREDGTLQCI
QGPAEVPMMS PNGSIPPIHV PPGYISQVLE DTTGVRRVVV TPHSECYPPS YSPAISPTHH
LPPPYMTHPH FIPTSHTAYY PPASPGDVPP HQYYQHRLPP IYPEEIIPLY NMSTFLGREE
YCKPQPKKPK ERPTERQSLS RVSTPPSSSY KNGSACNSTP NGYSKNHSGT AATGGGGGSP
GNKRTERRAR GSPKHTESDQ QDPVLDTRRD QDVPSGMDKP QVCKVQAHSA LVSWSRATQV
GASGRGQTDG APQSCSYELL LADKSCDGKY KVVYSGEELQ YTLTDLRPAT DYHVRVSAVC
NSVKGPHSEV RAFTTHSAPP ETPLPPRLSH RTKSSLTLQW KPPVDNGSKI TSYILEWDEG
KKNSVFRECY FGHQRHFKVM RLCPAVGYTF RVAALNDIGP SGFSPEVVFH TTGSLPQMPL
APRLLRAGTS WVALEWTRPS GCSPDEELTY TLEMQDDMNS DLICTPPLIW RPLQLTTCSA
EWRSTPSSIL VCRTTADKPG PPAAPRVSAV TSHGFCVTWD PPQDDGGCGD LTYLLEMSEG
NSEEYLTLFL PSLALSHFLS FCLALLLSVC IEGPVCDVEN ESLVYSVEMS GVEEEANPMQ
VYNGTHTECT VGSLLPGATY RFRVRAANDA GYGPYTEFVE VTTAAGPPGQ CVVPVINLTS
HTCAVVSWEV SLTALGSDIS GYQLDWGRDQ DSLEMIYNGT ETFCEISNLE AAASYCCRLQ
ATNQAGAGPY SDLAWCRTPA AAPDAVVSLY LQESVSLPAD EEPFSPSTCL ALAWDEPNCN
GQEITCYTIA MGETLITAGN ATCHVIRNLQ PDSEYRSVRA ENRVGAGPFG PSLQVRTKPL
PPSPPKLECA ATGPQSLKLR WGDSNSRGPI TDDTTYVLQM EDRNQRFVPI YRGPSHTFKV
QRLSESSRYT FRIQAVSEAG EGPFSDTHTF TTTKSVPPTL KAPRVAQLEG NACEVTWESV
PLMRGDRITY VLQVLGGKES EYRQVYKGED TSYQLFGLQW NTDYRLRVFV CRRLLDTSQE
LCGPFSPSTH FSPRRTNTAV ALEPGSVSTS TPKALTDEQF ASLIVLGVAG ASIIIAYLLQ
LLI
//
