ID W5K8E5_ASTMX Unreviewed; 907 AA.
AC W5K8E5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Taste receptor type 1 member 3 {ECO:0000256|ARBA:ARBA00040705};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003856.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003856.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR AlphaFoldDB; W5K8E5; -.
DR STRING; 7994.ENSAMXP00000003856; -.
DR Ensembl; ENSAMXT00000003856.2; ENSAMXP00000003856.2; ENSAMXG00000003767.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160679; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; W5K8E5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15290; 7tmC_TAS1R3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 629..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..893
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 907 AA; 99846 MW; 3CDF4A7618EBFD57 CRC64;
MLKSLGKDPE EQLADISSQN AVVSGSIFKL PGKKTYDLLR SSWTTERPLL LLLTTSMAGQ
WTLLILFYLI KAGHGENPLW FQNISTNFFR SSGDILLGGL FPINQLTSNL SERVEPDDIH
CNSIDPYGLA MALVMKYTID EINATPGLLP GVTLGFESYD CCRQPAVIMK PTLRFLTTGS
TEELEVKCNY TEYMTHVTAV IGPCNSEIAA VIGKLLGFFL MPQVSYRATS DVFSDKLQYP
SFVRTVPSDR WQAIAMVQLL KEFGWNWVAV IGSEDEYGKQ GKQQLSSLAA DEGICVAYEG
LIPVYSDPVP MIQEILQRIR DTKVGVVVVF SVSQATTVFF KEVIRANMTA VWVASTAWAL
NSGLIALPGI ETIGTVLAFA DMTKSVSLLS PYVHELFAKL DKERLQLGSS QPSPSTSPLD
NPCPDCWNLS SANASIVDTE LVQRTAFSVY AAIYSVAHAL HDTLDCSETK CSRHPKQDRV
YPWQLLKKLQ KVSLTLNNAN IEFDAEGNPS IGYDVVVWIF QNSTVYFRDI GNFTKNITID
KPLIKWHTAN SAVPTSTCSS DCQMGQVRIV KGFHSCCFDC IDCKEGTYQN KTDDIQCTPC
PSGQWSTLRS INCSLPTYTY LSWSSYESIG LTLAGVLLLV CQAGVSVIFF KHRGTPLVSA
TGGLLCALSL MSLVAGCASL VLFLGQPSDT VCRLQQPLNA IFPTVTLSTI LTISLQIVYV
TEFPERAPVV LQNLRGPGSW TVVLACCGLQ MGLCGWFARD GPSLTRYVAG LEVKFLTRFL
ACPVEPVLNF GLMLGFNGVL ALISFMCTFM AMKPVRQYNL ARDITISSLA YCVTWVIFIP
IYAGLSDKEK SIAQVMVTLL SNMALVGTYY GPKCYLLVKH PDLNTPDYFR TYLEGAPPIP
PEENEGK
//
