ID W5K9Q0_ASTMX Unreviewed; 1188 AA.
AC W5K9Q0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004311.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004311.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K9Q0; -.
DR Ensembl; ENSAMXT00000004311.2; ENSAMXP00000004311.2; ENSAMXG00000004211.2.
DR GeneTree; ENSGT01100000263529; -.
DR HOGENOM; CLU_002274_0_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004211; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 318..454
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 994..1188
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 44..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1188 AA; 133770 MW; 682C014E2C0DCC9F CRC64;
MSLREENDVA GSADIPEIQR VASPVPSWVS TMSDHSMFGR SAFRNEAKRP RLESQRAASP
VPSCVSMKSD HSMFEPPAFS DGPEHPRLEN HRTAPPVPSG VSIKSGHSMF EPPAFSGVFN
DLRLEINRTA SSEPSCVSMK CDHSMFEPPA FSDGPKQSRH GVCNQILKDP AGSSCGHSGS
SGTCASLQHK TKSTTESTLP SPRNTEECMQ HNPQVEDTLQ KVLVTHKASM KRKYECLFEG
IPTHENKTLL NSIYTQLYLV EGENKGVNEE HEVLQVQKLL GECVKGIPVN CNDIFKPLPE
QELEKHYERK GPAEGRFKTV LTKGIAGIGK TVSVQKFILD WAEGKANQDV DFVFLLPFRE
LNLIKDDQYS LHELLCIFHP ELKELDLKIL DSCKVMFIFD GLDESRISLS LTASKSKKVS
SMTMKSSVGT LMTEIIIGDL LSSALLWITS RPAAANQIPP RYISRVTEIQ GFDDPQKEEY
FKKKISDLSQ ANRVFSQIAK SKTLYIMCHI PIFCWISATV IQNLLNQDSF GNIPTTLTEM
YIHFMLMQTK TKMQKYHVSN EQDPVKCNAE MILKLAELAF KQLIKGNILF YEEDLLECGI
DVTEASVYSG MCTEIFKKES VLYQKKVYCF VHLSFQEFFA AIFAFHACLE KKSAVLKIFQ
TRNPKSHGRF VDEFLTSAMD SALKSKTGHL DLFLRFLYGI SAQSNWKLLT HILRPKSYVS
EQFLENIQRV KQKHPKNVSP ERWMNFSHCL IEMKNQIFQI ENKALLKTKK KLTQWECTSM
AFMLQLTDEV LDEFDPKTYN TSEDGRKRLI PLVRNCRKAV LTNIKPTTQD CEIIFSALQS
ANSTLTKLDL SYNNIQDSGV KQLCAGLKNP HCKLETLRLV MCNLTEQTCE FVAAALQAPH
SPLIELDLSQ NDLQDSGVKL LSDGLKSSHN QLKILGLSGC LVTEEGCASL ASALSSNPSH
LRELDLSYNH PGESGMKMLC AKVDSPNCML KKLNLDSGGM STIKPGVRKY ACELTLDMNT
ISNQLALSEE NRKVTFVLDD ELQPPYPDHP ARFDCTQVLC REPLTGRCYW EAEWSGWKAG
IAMAYKGIPK NSKSPTEFGS NDKSWALFYH NNKYSVLHKH KKTAIPIPRS HSNRVGVYLD
WPAGTLSFYC VSSDLHTLIH LHTLQYRFTE PLYAGIFVYD SSVTLCHV
//
