ID W5KB73_ASTMX Unreviewed; 704 AA.
AC W5KB73;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cyclic nucleotide gated channel subunit alpha 3b {ECO:0000313|Ensembl:ENSAMXP00000004834.2};
GN Name=CNGA3 {ECO:0000313|Ensembl:ENSAMXP00000004834.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004834.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004834.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007241953.1; XM_007241891.2.
DR AlphaFoldDB; W5KB73; -.
DR STRING; 7994.ENSAMXP00000004834; -.
DR Ensembl; ENSAMXT00000004834.2; ENSAMXP00000004834.2; ENSAMXG00000004726.2.
DR eggNOG; KOG0500; Eukaryota.
DR GeneTree; ENSGT00940000158737; -.
DR HOGENOM; CLU_005746_12_0_1; -.
DR InParanoid; W5KB73; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004726; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF6; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 501..615
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 641..693
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 75..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 80840 MW; 9D6631B0FEB9E757 CRC64;
MAKICTERSY ATRRSAFTPE PRSDWTDGND GDPPSHGATG RISRFVLTLG GWVSHGKHSE
SSCSSADGSD EAGRDEGNLN TTNGQDQLRR RNFNKNVSPW PLATLNMNNC NNTDDKKDNK
EIKKDDKKPD EKKDEKKEEK KDDKKDEKKD EKKDEKKDEK KDDKKDDKKK EEPPKESWIM
DPASDLYYHW LTIISVPAFY NLMMLITRAC FNELQDSYTT VWITLDYSSD VIYYIDTFVR
SRTGFLEQGL LVKDRKKLWE NYKKTPQFRY DLVSMIPTDI AMLYVGYNNP ELRFNRLLKM
ARLFEFFDRT ETRTNFPNIF RIGNLVLYIL IIIHWNACIF FAISKTLGFG SDTWVYPDIS
DPEHGRLARK YIYCLYWSTL TLTTIGETPP PVRDIEYLFV VADFLIGVLI FATIVGNVGA
MISNMNASRA EFQAKIDSIK QYMQFRKVTK DLEARVVKWF DYLWTEEKTC DEKEVLKYLP
DKLKAEIAIN VHLETLRKVR IFQDCEAGLL IELVLKLQPQ VFSPGDYICK KGDIGREMYI
IKEGKLAVVA DDGVTQFVVL SDGAYFGEIS ILGIKGSKAG NRRTANIRSV GYSDLFALSK
DDLMEALTEY PEAKKALEEK GRAILMKDGL IDESAAKTAD AKDLEDKVSM LETNLEVMQA
KMTRITADWA ASQGRIKQRI NNMEARVKTL REEDLSEVVE DKKG
//
