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Database: UniProt
Entry: W5KBL7_ASTMX
LinkDB: W5KBL7_ASTMX
Original site: W5KBL7_ASTMX 
ID   W5KBL7_ASTMX            Unreviewed;      4834 AA.
AC   W5KBL7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAMXP00000004978};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004978, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000004978, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004978};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000004978}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000004978}.
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DR   EMBL; APWO01027432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01027433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01027434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01027435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000004978; ENSAMXP00000004978; ENSAMXG00000004818.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; RAILSMP; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4375   4395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4434   4460       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4584   4612       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4632   4654       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4713   4734       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    251       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      257    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      322    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      554    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1190       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1236   1446       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3910   3936       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4834 AA;  547235 MW;  9C4CFD3C69A124A8 CRC64;
     DDEVVLQCVA TIQKENRKFC LSAEGLGNRL CYLEPTSEAK YVPPDLCICN FVLEQSLSVR
     ALQEMLANTG QNGEGAGQGG GHRTLLYGHA ILLRHSFSGM YLACLKTSRS LTDKLSFDVG
     LQEDSTGEAC WWTIHPASKQ RSEGEKVRIG DDLILVSVSS ERFLHLSMSN GNIQVDASFM
     QTLWNVQPTC SGSNVAVGYL LGGHVIRLFH GHDESLTVPG SDQSGEQQRV ANYEAGKGGS
     RARSLWRLEP LRISWSGSHI RWGQPFRLRH LSTGHYLGQT EDRGLVLLDR EKSDTTATAF
     CFRPSKEKVD SGSKRDIEGM GVAEIKYGDS VCFIMHVATG LWLSYQAPDA KSSRLGLLKR
     RAFLYPEGHM DDGLILQLCQ HEESRAARII RNTTQLFTQF ISGLDELKGE KASEVSLPVG
     EVMQTLDDLI TYFQQPDPDL EHEEKQRQLR SLIKRQDLFK EEGMLTLVSV CIDRLNVYSS
     AAEFEEFAGE EAGEAWKDIL NLLYELLAAL IQGNRPNCTQ FSRKLDWLIS KLERLESSSG
     ILEALHCILT ESPEALNIIQ KVHIKSIISL LYKHGRNHKI LDILCSLCVC NGVAVRTNQN
     FISEHLLPRR DVLLQTKLVN DVQSMRPNIF LGMSEGSAQY RKWYFELIID QVDHFVTGEP
     THLRVGWATT KGYAPYPGGG EGWGGNGVGD DLYSYSFDGL HLWSGRIPRA VASINQHLLT
     SDDVVSCCLD LGAPSMSFRI NGQPVQGMFE DFNTDGFFFP VVSFSAGVKV RFLLGGRHGD
     FKFMPPAGYA PCYEALLPKE KMRVEPVKEY KRDLEGVRDL LGTTKLLSQA SFIPIPVNTA
     EIVLPPHLEN VRDKLAENIH ELWGMNKIEL GWTYGKIRDD NKRQHPCLVD FSKLPETEKN
     YNLQMSTETL KTLLALGCHV AQVQVDAEED LKRIKLPKDY MMSNGYKPAP LELSEVKLTP
     GQEVLVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKSRRNP RLVPYALLDE RTKKSNRDSL
     REAIRTLIGY GYNIDPPDQE TANVIEKLNV ENIRFFRVEK TYAVTSGKWY FEFEAVTGGE
     MCVGWARPGC RPDIELGLDD QAFVFDGCRG RRVHMGSHFF GRSWNKGDVV GCMINMEDKS
     MIFTLNGEIL ITNRGSELCF ADFDTEGGFI PVCSLGLSQI GRMNLGKDAS TFKYYTMCGL
     QEGFEPFAVN MNRDVTMWFS KRLPTFVNVP EDHKHIEVTR IDGTVDTPPC LKVTHRTFGT
     QASNNDMIYC RLSMPVEFYP GPRKTTNINE VIADDQNVKK DDSGKTDYQY FYSVRVFAGQ
     DPAAVWVGWV TPDYHYYSKH FSLNKVRTVT VTLGDERGRV HESVRRSNCY MVCAGEISNS
     SSGRSNTDLE IGCHIDLASG LVSFTANGNE LPTAYQVEPN TKLFPAVFIE PTSPNLFQFE
     FPKIQDAMPL SSAIFKSLHR NPESQCPPRL DVQTIVAVLW SRMPNSFLSV ETARVSERHG
     WVVQCLEPLQ MMAVHIPEEN RCIDIMELSE NEDLRMFHYQ TLKLYCALCA LGNTRVAHAL
     CSHLDQSQLL YTIDNQYLTG QLREGFYDVL ISICLETAKE ARLMMNNEFI IPVTDETRSI
     RLFPDESKRH SLPGVGLSTS LTPRLNFNPP CFITTKREHT YSPQIPLGIL KEKAISMLTE
     AVQGGGTHIR DPVGGSVEYQ FVPILKLIGT LLIMGALTSE EVRLILLLIE PNVFADNKEE
     EKPAAEEAVE KEEASSNEEK TVVAGEEESK DSKPAPKGLL EKSLPEPVKR QMCELLNYFC
     DCELKQRIEA IVAFSDHFVA KLQYNQKFRY NELMQAFNMS AAVTAKKTKE FRSPPQEQIN
     ILLNFSAGED CPCPEEIQEE LQNFHDDLRL HCGIPMEEEE EEQDTSIKGR LLSLLYKIKG
     RPQKTEEEPS EQEQATPTNL KELISQTMVS WAQECTIQDP ELVRIMFSLL RRQYDGIGEL
     LRAMRKSYTI SEKSVQDAIN LLASLGQIRS LLSVRMGEEE GQLMIDGLGD IMNNKVFYQH
     PNLMRVLGMH ETVMEVMVNV LGGDKSKEIA FPKMVASCCR FLCYFCRISR ENQKAMFDHL
     SYLLENSSVG LACPAMRGST PLDVAASSVM DNNSLALALE EPDLEKVVTY LAGCGLQSCP
     MLVAKGYPDI GWNPIEGERY LSFLRFAVFV NGESVEENAN VVVKLLIRHP ECFGPALRGE
     GGQGLLAAML EAIKISEDPT LDLPNLPEGG GPVIGEDGEE EEVAHMGNSI MSFYSALIDL
     LGRCAPEMHL INKGKGEALR IRAILRSLVP TKDLVGIISI PLKVPVINKD GTVTEPDMNS
     SFWPDHKSPM VLFLDRVYGI EDQSFLLNLV EVGFLPDLRA SASLDTEVLS TTETALAMNR
     YIGSAVLPLL TRCASLFAHT EHYAQLVDST LHTIYRLSKG RSLTKAQRDS IEECLLAICQ
     HLRPSMLQQL LRRLVFDVPQ LTEYCKMPIK LLTNHYEQNW KYYCLPSGLG SYGMASEEEL
     HLTKKLFWGL FDALSQKKYD SELFKMAMPC LSAIGGALPP DYVDTSPTTT LVKQVSVDTQ
     GNFDPKPINT ANISLPEKLE YIANKYAEHC HEKWSSEKFA QGWTAGEKVN EQAKTHPLLK
     PYKALSEKDR ETYRYPVKES LKSMLAMSWN IERTKEGEAM FQQRETEKLK TTEPSQGDGF
     NPTPVDLDNV ILSRELQSMV ETVAENYHNI WAKKKKMELS SKGGGTHPLL VPYDTLTAKE
     KYRDREKAQE LFKFLQLNGY ALSSRGFKDM EQDSSSMEKR TAYKFLKRLL SYVDSAQEFI
     AHLEAMASSG KTDKSPHEQE IKFFAKVLLP LIDQYFKNHC LYFLSSPSIS LSSSGYASNK
     EKEMITSLFC KLASLVRHRI SLFGSDSATM VSCLHILACS LDFRTVMKSG SELVKAGVRT
     FFENAAEDLE KTMENLKLGK LGQSRTQMKG VAQIIVYTST ALLPILTALF QHVTQHQFGV
     DLLLDDVQLS CYRILTSLYS LGTGKNSYGL NRQLPALGEC LATLVGAMPV AFLEPDLNMH
     NPCSVFNTKT PRERAILSMP DTVEEMCPEM PRLDGLMKDI HDISESGARY TDMPHVIEVI
     LPMLCNYLSY WWEKGPENSP SDMDCCTTVT SEHLSLILGN ILRILNNNLG IEEASWMKRL
     AVYTQPIISK AGADLLRTHF LPTLEKLKKK TVKVVSEEEL LRAESRADTQ EAELQILDEF
     AVLCRDLYAF YPMLIRYVDN NRSKWLKKPH ADSTELFKMV AEIFILWCKS HNFKREEQNF
     VVQNEINNLA FLTGDSKSKM SKSGGQDQER RGKKRKRELY SVQTSLIVSA HKKLLPIGLN
     MCTPGDQMLI SLAKIRYCLK DTDDEVKDHL KQNLHLQEKS EDPGVQWQLN LYKDVEMKSE
     EASDVEHTVE RIQGISAAVF HLEQVELPLR NKKLVAQKLL SKQRKRAVVA CFRMAPLYNL
     PRHRSINLFL TGYQRLWIVA EEYSFEEKLV QDLAKTPMVV EKEEEEAEAE VQPDPLNQLI
     LHFSHNALTE RSFLEIDPLY IAYADMMAKS CAEDEEEEEE GKEKTFEEKE MEKQKTLYQQ
     ARLHARGAAE MVLQMISASK GRLGPMVTCT LKLGISILNG GNVVVQQKML DYLKEKRDAG
     FFKSLSGLMM SCSVLDLNAF ERQNKAESLG MVTEEGSINV SERGSKVLQN DDFTKDLFRF
     LQLLCEGHNN DFQNFLRTQT GNTTTVNIII STVDYLLRLQ ESISDFYWYY SGKDIIDEQG
     QRNFSKALAV AKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD AVVGFLHVFA NMQMKLSQDS
     SQIELLKELM DLQKDMVVMM LSLLEGNVVN GTIGKQMVDT LVESSSNVEM ILKFFDMFLK
     LKDLTTSDNF KEYDPEGKGM ISKKEFQKSM ESQKQYTQSE IEFLLSCTEA DENDMFNYAE
     FVERFHEPAK DIGFNVAVLL TNLSEHMPHD SRLGTFLDLA ESVLSYFEPY LGRIEIMGGA
     KRIERVYFEI SESSREQWEK PQVKESKRQF IFDVVNEGGE SEKMEMFVNF CEDTIFEMQL
     ASQISEQDAA ERPEEEEEEL QSLLEELAEG EDGSQESASA FTLACTSMKK KMSNFRQMLT
     IKSMRKQFKK FKKLTIKEMI TGFFSFFWML FTGFFKGIFG LIFGFFHIIW SSMFGGGLVE
     GAKNMKVTDI LGNMPDPTQF GIHGDVLEAE KMESSDFVVS TEMVQMAGAG DKMEPDSIID
     LINPAPKREG KHGPEPGLGD VSEIMTEVSQ PVEKKKSQKA ATEESEPEKA DTEHQEKEDK
     AKEEKPEEPV VEEKPAPRKR HGTAKEEATA FMASFFAGLE VYKTKMLNYL ARNFYNLRML
     ALLVAFAINF ILLFYKVSGE TEEEEEDESP WGGDDEDEDG GGMEFFVLQE STGYMAPTLT
     FLAVLHTIIS LLCVVGYYCL KVPLVVFKRE KEIARTLEFD GLYITEQPSD DDIKGQWDRL
     VIATPSFPNN YWDKFVKRKV INKYGDLYGA ERIAELLGLD KSALDFDPTE EAVVKEASLL
     SWLSSIDTKY HIWKMGVVLT DNSYLYLIWY TTMSILGHYN NFFFACHLLD IAMGFKTLRT
     ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDAPDMK CDDMMTCYLF
     HMYVGVRAGG GIGDEIEDPA GDPYELYRIL FDITFFFFVI VILLAIIQEL GLIIDAFGEL
     RDQQEQVKED METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH
     TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLG
//
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