ID W5KBR1_ASTMX Unreviewed; 275 AA.
AC W5KBR1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Metaxin 2 {ECO:0000313|Ensembl:ENSAMXP00000005022.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005022.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005022.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR AlphaFoldDB; W5KBR1; -.
DR STRING; 7994.ENSAMXP00000005022; -.
DR Ensembl; ENSAMXT00000005022.2; ENSAMXP00000005022.2; ENSAMXG00000004894.2.
DR eggNOG; KOG3027; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_6_0_1; -.
DR InParanoid; W5KBR1; -.
DR OrthoDB; 2897805at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004894; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03211; GST_C_Metaxin2; 1.
DR CDD; cd03079; GST_N_Metaxin2; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF38; METAXIN-2; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 41..161
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 187..249
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 256..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31147 MW; 8EA119DDA26A686F CRC64;
MSLAAEAFVS QMAAAEPWPE NATLYQPLRE HQILLSDCAS SLAVQAYLRM CNLPVRVSCR
ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FTKAKGHSLS DGLDDVQRAE MKAYMELVNN
MLLTAELYIQ WCDDTTSSEI SRPRYSSPYS WPLNHILAYQ KQWEVRRKMN AIGWAGKSLE
QVYEDVSQCC QALSQRLGTQ PYFFNKQPTE LDALVFGHLF TILTTRLTSD ELSEKIKSYS
NLLSFCRRIE QTYFEEQDRD SQSGASHHSK GPSLI
//
