ID W5KE89_ASTMX Unreviewed; 1028 AA.
AC W5KE89;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSAMXP00000005900.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005900.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005900.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR AlphaFoldDB; W5KE89; -.
DR Ensembl; ENSAMXT00000005900.2; ENSAMXP00000005900.2; ENSAMXG00000005709.2.
DR eggNOG; KOG0385; Eukaryota.
DR GeneTree; ENSGT00940000157297; -.
DR HOGENOM; CLU_000315_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005709; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; ISW-1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1028
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017397325"
FT DOMAIN 160..325
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 455..606
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 807..859
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 119964 MW; B47299652207BEC8 CRC64;
MCFGVLHLYL FNNLTSSVFK DGTSDAGHDE ASETAQESGD QSSSPADESA NMEQPSGYEE
KVKTDRTNRF EYLLKQTEVF AHFIQPAAQK TPTSPLKMKP GRPLLLLIYR HPYRHQEEDE
ELLSENSKAS NVCTRFDDSP SYVKTGKLRD YQVRGLNWLI SLYENGINGI LADEMGLGKT
LQTISLLGYM KHYRNIPGPH MVLVPKSTLY NWMNEFKRWV PSLRAVCLIG DRDERTAFIR
DTLLPGEWDV CVTSYEMLII ERAVFKKFNW RYLVIDEAHR IKNEKSKLSE IVREFKTTNR
LLLTGTPLQN NLHELWALLN FLLPDVFNSS EDFDSWFDTN NCLGDTKLVE RLHTVLRPFL
LRRIKADVEK SLLPKKEIKM YIGLSKMQRE WYTKILMKDI DILNSAGKMD KMRLLNVLMQ
LRKCCNHPYL FDGAEPGPPY TTDLHLVVNS GKMAVLDKLL PKLNEQGSRV LIFSQMTRVL
DILEDYCMWR NYGYCRLDGQ TPHEERQISI NAFNEPNSSK FIFMLSTRAG GLGINLATAD
VVIIYDSDWN PQVDLQAMDR AHRIGQKKQV RVFRFITENT VEERIVERAE MKLRLDSIVI
QQGRLVDPNM NKLGKDEMLS IIRHGATHVF ASKESEITDE DIDAILERGE KKTMEMKEKL
SNLGESSLRN FTMDTENSVY NFEGEDYREK KKVITNWIEP PKRERKANYA VDAYFREALR
VSEPKAPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR KTIGYKVPRN PELPNSAQVQ
KEEQAKIDEA EPLNEEELEE KENLLSQGFT IWNKRDFNQF IKANEKWGRD DIENIAREVE
GKTPEEVMEY SAVFWERCNE LQDIEKIMAQ IERGEARIQR RISIKKALDS KIGRYKAPFH
QLRISYGTNK GKNYTEEEDR FLICMLHKLG FDKESVYDEL RQCIRNSPQF RFDWFLKSRT
AMELQRRCNT LITLIERENM ELEEREKAEK KKRGPRTSSV SLLQLRFALS QQGKLHQSYP
KQSSMSCH
//