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Database: UniProt
Entry: W5KE89_ASTMX
LinkDB: W5KE89_ASTMX
Original site: W5KE89_ASTMX 
ID   W5KE89_ASTMX            Unreviewed;      1028 AA.
AC   W5KE89;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSAMXP00000005900.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005900.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000005900.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC       {ECO:0000256|ARBA:ARBA00009687}.
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DR   AlphaFoldDB; W5KE89; -.
DR   Ensembl; ENSAMXT00000005900.2; ENSAMXP00000005900.2; ENSAMXG00000005709.2.
DR   eggNOG; KOG0385; Eukaryota.
DR   GeneTree; ENSGT00940000157297; -.
DR   HOGENOM; CLU_000315_0_0_1; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000005709; Expressed in embryo and 14 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR   CDD; cd00167; SANT; 2.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR015194; ISWI_HAND-dom.
DR   InterPro; IPR036306; ISWI_HAND-dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR015195; SLIDE.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR   PANTHER; PTHR45623:SF49; ISW-1; 1.
DR   Pfam; PF09110; HAND; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF09111; SLIDE; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..1028
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017397325"
FT   DOMAIN          160..325
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          455..606
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          807..859
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   REGION          23..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1028 AA;  119964 MW;  B47299652207BEC8 CRC64;
     MCFGVLHLYL FNNLTSSVFK DGTSDAGHDE ASETAQESGD QSSSPADESA NMEQPSGYEE
     KVKTDRTNRF EYLLKQTEVF AHFIQPAAQK TPTSPLKMKP GRPLLLLIYR HPYRHQEEDE
     ELLSENSKAS NVCTRFDDSP SYVKTGKLRD YQVRGLNWLI SLYENGINGI LADEMGLGKT
     LQTISLLGYM KHYRNIPGPH MVLVPKSTLY NWMNEFKRWV PSLRAVCLIG DRDERTAFIR
     DTLLPGEWDV CVTSYEMLII ERAVFKKFNW RYLVIDEAHR IKNEKSKLSE IVREFKTTNR
     LLLTGTPLQN NLHELWALLN FLLPDVFNSS EDFDSWFDTN NCLGDTKLVE RLHTVLRPFL
     LRRIKADVEK SLLPKKEIKM YIGLSKMQRE WYTKILMKDI DILNSAGKMD KMRLLNVLMQ
     LRKCCNHPYL FDGAEPGPPY TTDLHLVVNS GKMAVLDKLL PKLNEQGSRV LIFSQMTRVL
     DILEDYCMWR NYGYCRLDGQ TPHEERQISI NAFNEPNSSK FIFMLSTRAG GLGINLATAD
     VVIIYDSDWN PQVDLQAMDR AHRIGQKKQV RVFRFITENT VEERIVERAE MKLRLDSIVI
     QQGRLVDPNM NKLGKDEMLS IIRHGATHVF ASKESEITDE DIDAILERGE KKTMEMKEKL
     SNLGESSLRN FTMDTENSVY NFEGEDYREK KKVITNWIEP PKRERKANYA VDAYFREALR
     VSEPKAPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR KTIGYKVPRN PELPNSAQVQ
     KEEQAKIDEA EPLNEEELEE KENLLSQGFT IWNKRDFNQF IKANEKWGRD DIENIAREVE
     GKTPEEVMEY SAVFWERCNE LQDIEKIMAQ IERGEARIQR RISIKKALDS KIGRYKAPFH
     QLRISYGTNK GKNYTEEEDR FLICMLHKLG FDKESVYDEL RQCIRNSPQF RFDWFLKSRT
     AMELQRRCNT LITLIERENM ELEEREKAEK KKRGPRTSSV SLLQLRFALS QQGKLHQSYP
     KQSSMSCH
//
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