ID W5KEA0_ASTMX Unreviewed; 940 AA.
AC W5KEA0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=WD repeat domain 3 {ECO:0000313|Ensembl:ENSAMXP00000005911.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005911.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005911.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family.
CC {ECO:0000256|ARBA:ARBA00038229}.
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DR STRING; 7994.ENSAMXP00000042518; -.
DR Ensembl; ENSAMXT00000005911.2; ENSAMXP00000005911.2; ENSAMXG00000005755.2.
DR Ensembl; ENSAMXT00000039867.1; ENSAMXP00000042518.1; ENSAMXG00000005755.2.
DR eggNOG; KOG0306; Eukaryota.
DR GeneTree; ENSGT00940000153859; -.
DR HOGENOM; CLU_005318_0_1_1; -.
DR OrthoDB; 168440at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005755; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProt.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19853; WD REPEAT CONTAINING PROTEIN 3 WDR3; 1.
DR PANTHER; PTHR19853:SF0; WD REPEAT-CONTAINING PROTEIN 3; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 10.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF117289; Nucleoporin domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 104..137
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 146..187
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 188..222
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 406..446
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 487..521
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 583..624
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 625..666
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 667..699
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 802..904
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
FT REGION 231..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 753..783
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 940 AA; 105308 MW; 2D7C421984053015 CRC64;
MGLTKQYLRY NASAVFGVIG SQKANIAYVT LRGGEKGRYV AVGACEHVFI WDVRKAEKVL
ILQGSKHDAT YLCPSPDGVH IAVGYEDGCV RIFSLLNGEN NVSFNGHKSA VTSIQYDALG
ARLVTGSRDT DVIVWDVINE CGLYRLKGHK DAITQALFLK DRNLLVTSSK DSFVKWWDLD
TQHCFKTMVG HRSEVWGMVL LNQENRLLTG SADSELRGWD IEYLEEGKEV GEPMEKKGKS
LLDDDEADSG DEGPNEDPEE RILSCKKAGS VIREGRDRVV SLTADPKAKV VACHGVDGYL
ELFSVVPEED VQKKIEKKLK KARKKAKSQE GGGEAADPVV ERKLTDELEK LTNIKASSKI
RSVDCILFPN GELKVALLLQ NNTIETYNLN TTEKNATGTK TSRLTLAGHR TDARTLAFSS
DNIAVLSASG DTVKVWNRAT LQVIRTMACE YALCSLFVPG DRQIILGTKS GKIQIFDLAS
GSLLETREAH DGALWSVCLS PDQRGIVTGG ADKTVKFWDF ELIKDKDSGP NKRLTLKHTR
MLQLDEDVLC VRYSPDQRLL AVSLLDCTVK IFYTDTLKFF LSLYGHKLPV LCLDISHDSA
LIATGSADRN VKVWGLDFGD CHRSMFAHDD SVMFLQFVPK THLFFTAGKD RKIKQWDADK
FEHIQTLEGH KGEVWCLAIS PSGDYVVSSS HDKSLRLWER TREPIILEEE KEMEREAEFE
ESLGKGEEPV VPGETKGEAE PAGKKTIETV KAAERIMEAL ELYREESKKL EEHKAACEAA
GKQLPPPKTN PILVAFGNIS PSRYVLDVIK KVRSSELEVS LLVLPFPYIP DLLSLFNSYV
QQGLEVELVC RCLFFLLRIH FGQITSNHML LSVIDDLRTN TISKVREIRD VLGFNSAGLQ
FLQREIESKE DVMFFADATD RFEEKKRKRR KRERAILTIT
//
