ID W5KG69_ASTMX Unreviewed; 995 AA.
AC W5KG69;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=EMAP like 3 {ECO:0000313|Ensembl:ENSAMXP00000006581.2};
GN Name=EML3 {ECO:0000313|Ensembl:ENSAMXP00000006581.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006581.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006581.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR AlphaFoldDB; W5KG69; -.
DR STRING; 7994.ENSAMXP00000006581; -.
DR Ensembl; ENSAMXT00000006581.2; ENSAMXP00000006581.2; ENSAMXG00000006165.2.
DR eggNOG; KOG2106; Eukaryota.
DR eggNOG; KOG3554; Eukaryota.
DR GeneTree; ENSGT00940000159589; -.
DR HOGENOM; CLU_259667_0_0_1; -.
DR InParanoid; W5KG69; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006165; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR CDD; cd21949; TD_EMAP3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF15; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 3; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 322..391
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 683..715
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 766..807
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 812..845
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 91..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..244
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 109925 MW; E0ED01775C29EFC3 CRC64;
MDGSTNSLDD VSAGSSAEFP DRLSLMEVRL QAQEDEITLL KSSLADALRK LRLHDQQIPL
LKQQLIAVNP GAARVLNQSF CIDGYSKPCR HSTSSLDGLH HPVNSHVLNS ENGEGSTAHS
VPTVKSSTSE SSTQTDPWTP EPTRTPLAPS KSLCLEDALP EGVSLMEEAL NKLHQETQEE
ESTNEEEREK DRSWRSLVED PIQPTTIRTL QQQHSKSSEE SQGSAPQTPT SSSPAPPKEP
SSSPHSGPLS PIMESEKILV RRNSEKQSKD IQDKAKQRMP KKAASSTNLL TRSPSLEGRA
KDLLSNTGSQ GSRRGTQGHS IKMFIRGRPI TMYVPSNIQN YDDLRMDLPS EKLDLDWVYG
YRGRDCRGNL YMLPSGEAVY FIACVVVLYH VANRTQRHYR KHTDCVRCLA IHPDKVLIAS
GQTAGVDKDG KPLQPFVHIW DSTTLVTLQQ IGMGTFERGV GSVAFSNADA GAFLCVIDDS
NEHMLSLWDW NKNTKVVEVK STNEAVFAVE FNPADTNNII TCGKSHVYFW TLSAGTLTKK
QGIFGKYKKP KFIMCFVFSL TGDVLTGDSE GNILTWGKSA ADIKTLGKGA KETFQIMKQT
RAHEGSVFTL CVLQGGALLS GGGKDRRIIR WSADLAPERE CEIPEKFGAV RTIADVDGEE
LLVGTTRNAI LRGSFSDGFV AIVQGHVDEM WGLATHPFQN IFLTCGNDKQ VCLWNAEEHT
LGWCTTLEES GLCADFSPNG AVVSVGLWTG RWVVLDLQTR EVVSDLIDGN EQLSVMRYSP
DGSFLAVGSH DNLIYIYSVT EGGRRYTRFG KCTGHSSFIT HLDWSKDGKY IMSNSGDYEI
LYWDVAGGCK LLRNRYESKD REWASYTCVL GFHVMGVWLE GSDGTDINAL CRSHSERIVA
VADDFCKVHL FQYPCPKPKA PSHRYEGHGS HVTNVRFTHC DSHLLSLGGK DTCILQWRVK
RSGAAEKEHP TSSLPPPTSI NSSSEPGKQK EKEMG
//
