ID W5KIF8_ASTMX Unreviewed; 480 AA.
AC W5KIF8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Neutrophil cytosolic factor 2 {ECO:0000313|Ensembl:ENSAMXP00000007370.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007370.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007370.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KIF8; -.
DR STRING; 7994.ENSAMXP00000007370; -.
DR Ensembl; ENSAMXT00000007370.2; ENSAMXP00000007370.2; ENSAMXG00000007179.2.
DR eggNOG; KOG4225; Eukaryota.
DR GeneTree; ENSGT00530000063843; -.
DR HOGENOM; CLU_041290_0_0_1; -.
DR InParanoid; W5KIF8; -.
DR OrthoDB; 11738at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007179; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR CDD; cd12046; SH3_p67phox_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR034889; NCF2_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF3; NEUTROPHIL CYTOSOL FACTOR 2; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 121..154
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 240..299
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 421..480
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 480 AA; 53733 MW; 0462493B7FDE18EB CRC64;
MSFVSTLRQW DEAVAYAEKG DVAAALRTFQ DIEEKTSKIA FNIGCLHLNA DDFEAAEKAF
DCSIRKDEHL AVAFFQRGIT FYKKEKFEES LLDFQQAFKE LRGNQLIDYK PLGLRYKLYA
SEVLHNIGLL YANLGKWEQA QENLSAALNV RTEAKSSHID KALESILKQK LFSLAVIKPG
LLFKPNKKYV AELEKKDYLG KAKVLSSVVP ADSFSGFAPL QPQVEDVPAT PKAPEVLRAL
EGEPHTVLYE FIPETKEELA VLPGNVVFVL QRGADNWASV IFNERRGLVP YNFLEPLDIT
VASRVMPVTP VQSNENIPAP PRREAPSKPM NGTEASFGCI VKVHFVFTIA ICIKPGQPYQ
TMLQKISTKV KRPASALTLS YVKPGSEKRE TVDESEMELL WSCIKKNRLT LWCSATEDKS
VTQKKMVALY SYEASTPEDL EFSQGDVITI LSNVNEEWLE GECNGKIGIF PSTFVTDQVG
//
