ID W5KIH5_ASTMX Unreviewed; 2718 AA.
AC W5KIH5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Teneurin-1-like {ECO:0000313|Ensembl:ENSAMXP00000007387.2};
GN Name=TENM1 {ECO:0000313|Ensembl:ENSAMXP00000007387.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007387.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007387.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7994.ENSAMXP00000007387; -.
DR Ensembl; ENSAMXT00000007387.2; ENSAMXP00000007387.2; ENSAMXG00000007150.2.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR InParanoid; W5KIH5; -.
DR OrthoDB; 5491728at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007150; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF7; TENEURIN-1; 1.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 299..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..297
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 567..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 633..666
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 697..728
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 737..772
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 589..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 656..665
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 701..711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 718..727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 741..751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 762..771
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2718 AA; 300258 MW; 354E127511CD5A19 CRC64;
MDDNVYQSLS RPRPGMELSY SSSSEEDEGA DLRHKHYRDT HSHTHSDYEP DRRFTYNSHK
VRRKPNELTQ KEPAQMAFPD FQTELHSANQ ELAYPGGGAS VGMASDPESE GGASPDHALR
LWMQEVKSER TSCVSSRANS VLSLTDTEQE GRGEQDNDND LPSSPVARFS FRPLPPPPPP
PHACTCVRPA PSAAPELIQR NTLPARGHQS ESSKTAQDDS GQSENTWALN SNIPLETRHF
LFKHGSGSST LFNATNQNYP LTSSTVYSPP PRPLPRAPLS RPLFSFSKPY RCCNWKCTAL
SASAVTVTLA LLLTYVIVVN LLGLPWSLRR LDAELFENGK AGRSQEEGND LISTAQLPTP
NTSHTDKDPL QRGRGIDRGE VDIGMQMVQV IPPGQFWRFS VVVQHPEYVR FNITHTHNAL
LGIYGRRNLP PTHTQFDFVK LLDGKLKQES RISDFTKVSS GLLTALQETV FMEYLDLGNW
HLAFYNDGRK MEQVQVHSTA VEMMDGCSTN CNGNGECVAG HCHCFTGFLG PDCSKDSCPV
LCSGNGEYEK GVCACRVGWK GAECEVEDGQ CIDPTCSNNG ECVDGTCVCA PAFKGNNCEE
VDCVDPTCSG RGVCVRGECV CSAGWGGEVC ETPLPACKEQ CSRHGTYNPE TGVCVCEQGW
TGTDCSTEVC PLPCSVHSVC AGGRCQCEDG WEGPTCDRQA CHPSCEEHGE CRDGQCVCHP
GWEGEHCTIA HYLDLLDKDA CPGLCNGNGR CTLEQSGWHC VCQSGWSGPG CNIVMETQCN
DSGDNDGDGL VDCVDPDCCS QQVCANSPLC QGSPDPRDII QQNHAPFGPR PSLQFFDRVQ
FLVRRGSTHI LPGDLPYDSS RVCVIRGQVV SSDGTPLVGV NVTFQQNPEY GYTLSRQDGS
FDLLAVGGVS ITLLFQRAPF LPLTRSLWLP WNQFVVLGSV MMSRSEPRPP VCEDKNLIGP
NPTVLPAPLT LFAGNCQERG PVIPELQAVQ EEIEIAGSFL KLSYLSTRSP GYRSLLRVIL
THSLLPVGLA KVHLSVSVEG TLVTKWFPAS PNLIYVFSWN KTDVYGQQVT GLVQALVSVG
YEYESCPDFI IWQKRTAQLQ GFELISSHLG GWALDKHHTL NLESGILHKG DGENVFISQQ
PPLISTVMGT GTVRPIACPS CNGPAAERKL FAPVALACGS DGSIYVGDFN FIRRILPNGF
TVSILELRNR DIRHSTSPAH KYYLALDPVS EALYVSDSSS RRVLRLKAVT EPRDLSRNAE
VLAGNGEQCT PFHPNQCGDG GKATEASLIS PRGIAVDKYG SVYFVDGTTV RKIDKGIITT
VMGSNGLTST QPISCDTHMD ISQVRLEWPT DLAISPLDNS LYVLDNNLVL QVSEAGLVRV
VAGRPIHCPL AITDPTTLGP ASTRLMLEGA KAIAVSHQGV LYIAQTDDRK LSRVLEVNSN
GEMSTVAGTA SECDCKIDPD CDCFSGDGGY ARDAKLKSPS ALAVSPNGTL YIADLGNVRV
RSLVARRPRL TSDLLYEVMS VAQQEVYLFS PNGSHLYTRC LVTGDYLYNF TYVGAGLISA
VTASEGGAVQ VRRDSNGAPL WLVTPGGQVY WLNLSSAGTL RRVSALAHDL AQISYHGNTG
LLATMSNENA WTTVYEYNSD GHLINVTLPT GEVSSLHGDM GKSVKVEALT SNRENFITIT
NHSEDNTIYT LRQAHSVSVY RVSGDGSLWV TYASGMDVTL STEPHLLPGA LPGVTPGVVH
PTVGRCNITL PGEQIHSIIE WRQRREQARN YSTYERRLRA HNRNVLSIDY NQASRVGKVY
DDHRKFTLRL QYDDRGRPVL WAPSKFSDVR VSYTNDGLLA SIQRGNWSER RDYDNSRLIS
RTWANGKTWS YSFQEKSVQL LLHSQRRYTF EYDQTDYLMS ITLPSMVKHG LQTALSIGYY
RNTYTPPDAP GHALVQDYTP DGRLLQTLYM GSGRRVLYKY SRTSRLSEIL YDSTLVSFTY
DESSGAIKTV HLMQEGFVCT IRYRQTGPLV GRQIYRFSEE GLVNARFDYS YNNFRVTSMQ
AMINETPLPI DLYRYVDVSG RVEQFGKFSV ISYDLNQVIT THAMKHTKIF NPNGQVVEVQ
YEILKSIAFW MTLQYDNLGR IGNCDIRIGV DGNITRRSYE YDADGQLQSV AVDDRPQWRY
SYDLNGNINL LSHGNSARLT PLRYDLRDRI TRLGEIQYKT DDDGFLRVRG NVVFDYTSNG
LLAGALDRDS GKRVWYRYDG LGRRVSTRTS DGALLQFFYA DLNEPTRVTH WYNHTASEIT
SLYYDLQGHL IAMEMSSGQE FYIACDAAGS PLAIFSSRGQ VVKELRYTPY GDVYRDSNPS
FQLPFGFQGG LYDPLTRLVH LGRRDYDVVA GRWTTPNHDL WAEVSADPKP FNLYAFKNNY
PLGALQDVTK FTTDISSWLQ LFGFQLHNVV PGFPKLPVEN TEQTYEMMNV QSRTHSWDPS
KVVLGIQCEL QKLLQNFISL DRLPMTPAKS KPGGLRGRSP RFSALSSIFG KGVKFAVCAD
GVISAEIIGV ASEDSRRIAA VMNGAVYLRG VRFTVDGRDT HYFTKDSPLE ADLGVVWGGS
GAAGGGARVL ENGVNVSVSQ MSAVVAGETR RFADLVLQQG ALCFNIRYGA TPDEERTRVL
EGARLRAVTG AWLLEQRRVR DGEGGARVWT NKEKDELLSD GHVSGYEGFY VLPVEQHPEL
ADSPFNIQLI RQTDAGRR
//